Design and Synthesis of Novel Antibiotics
The increasing resistance of microorganisms to currently available antimicrobial agents represents a serious and growing global health concern. Antimicrobial resistance (AMR) arises naturally over time, driven by selective pressure associated with the extensive use of antimicrobial compounds. Geneti...
שמור ב:
| פורמט: | Online |
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| שפה: | אנגלית |
| יצא לאור: |
MDPI - Multidisciplinary Digital Publishing Institute
2026
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| נושאים: | |
| גישה מקוונת: | ONIX_20260416T142754_9783725853779_16 |
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| _version_ | 1869528447135514624 |
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| collection | Directory of Open Access Books |
| description | The increasing resistance of microorganisms to currently available antimicrobial agents represents a serious and growing global health concern. Antimicrobial resistance (AMR) arises naturally over time, driven by selective pressure associated with the extensive use of antimicrobial compounds. Genetic mutations and adaptive mechanisms allow sensitive microorganisms to acquire resistance, with bacterial pathogens showing particularly alarming trends—especially the rapid emergence and dissemination of multidrug-resistant (MDR) and pan-drug-resistant (PDR) strains. This phenomenon is exacerbated by the widespread use of antibiotics in clinical therapy, agriculture, and the food industry, contributing to the environmental accumulation of antimicrobial residues and further promoting resistance. As a result, there is an urgent need to develop novel antibiotics with alternative mechanisms of action and improved safety profiles. This Reprint presents recent advances in the design, chemical synthesis, and structural characterization of new antimicrobial agents. Emphasis is placed on the evaluation of their biological activity and cytotoxicity. The Special Issue includes both original research articles and review papers, offering valuable insights into current strategies aimed at overcoming antimicrobial resistance. |
| format | Online |
| id | doab-20.500.12854ir-174811 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1748112026-04-16T16:33:56Z Design and Synthesis of Novel Antibiotics Turecka, Katarzyna Onyedibe, Kenneth Ikenna Drug discovery Antimicrobial modes of action Antimicrobial resistance Structural characterization Antimicrobial activity thema EDItEUR::M Medicine and Nursing The increasing resistance of microorganisms to currently available antimicrobial agents represents a serious and growing global health concern. Antimicrobial resistance (AMR) arises naturally over time, driven by selective pressure associated with the extensive use of antimicrobial compounds. Genetic mutations and adaptive mechanisms allow sensitive microorganisms to acquire resistance, with bacterial pathogens showing particularly alarming trends—especially the rapid emergence and dissemination of multidrug-resistant (MDR) and pan-drug-resistant (PDR) strains. This phenomenon is exacerbated by the widespread use of antibiotics in clinical therapy, agriculture, and the food industry, contributing to the environmental accumulation of antimicrobial residues and further promoting resistance. As a result, there is an urgent need to develop novel antibiotics with alternative mechanisms of action and improved safety profiles. This Reprint presents recent advances in the design, chemical synthesis, and structural characterization of new antimicrobial agents. Emphasis is placed on the evaluation of their biological activity and cytotoxicity. The Special Issue includes both original research articles and review papers, offering valuable insights into current strategies aimed at overcoming antimicrobial resistance. 2026-04-16T16:33:49Z 2026-04-16T16:33:49Z 2025 book ONIX_20260416T142754_9783725853779_16 9783725853779 9783725853786 https://directory.doabooks.org/handle/20.500.12854/174811 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/ https://mdpi.com/books/pdfview/book/11690 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-5378-6 10.3390/books978-3-7258-5378-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725853779 9783725853786 166 CH open access |
| spellingShingle | Drug discovery Antimicrobial modes of action Antimicrobial resistance Structural characterization Antimicrobial activity thema EDItEUR::M Medicine and Nursing Design and Synthesis of Novel Antibiotics |
| title | Design and Synthesis of Novel Antibiotics |
| title_full | Design and Synthesis of Novel Antibiotics |
| title_fullStr | Design and Synthesis of Novel Antibiotics |
| title_full_unstemmed | Design and Synthesis of Novel Antibiotics |
| title_short | Design and Synthesis of Novel Antibiotics |
| title_sort | design and synthesis of novel antibiotics |
| topic | Drug discovery Antimicrobial modes of action Antimicrobial resistance Structural characterization Antimicrobial activity thema EDItEUR::M Medicine and Nursing |
| topic_facet | Drug discovery Antimicrobial modes of action Antimicrobial resistance Structural characterization Antimicrobial activity thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20260416T142754_9783725853779_16 |