Diabetes
Diabetes is one of the most challenging health problems in the 21st century, projected to affect 700 million people by 2045. In the last 15 years, the number of people diagnosed with type 1 diabetes increased by 45%, and those diagnosed with type 2 diabetes increased by 95%. The most devastating eff...
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| Format: | Online |
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| Język: | angielski |
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MDPI - Multidisciplinary Digital Publishing Institute
2026
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| Hasła przedmiotowe: | |
| Dostęp online: | ONIX_20260416T142754_9783725855575_11 |
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| _version_ | 1869515480373395456 |
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| collection | Directory of Open Access Books |
| description | Diabetes is one of the most challenging health problems in the 21st century, projected to affect 700 million people by 2045. In the last 15 years, the number of people diagnosed with type 1 diabetes increased by 45%, and those diagnosed with type 2 diabetes increased by 95%. The most devastating effects of diabetes are its chronic complications, which confer a high risk of morbidity and mortality and an increased health system cost burden. Although there is increased awareness and new therapeutic options in the treatment of diabetes, it is still the leading cause of blindness in working-age adults, the leading cause of kidney failure and dialysis, and the leading cause of nontraumatic lower-limb amputations. This Special Issue, featuring thirteen research articles, three reviews, and one systematic review, presents the latest knowledge of diabetes and its complications. Topics include the connection between circulating isthmin-1 levels and diabetes, material technologies for improved diabetic foot ulcer treatment, depression and stress in type 2 diabetes, metformin in gestational diabetes, safety of semaglutide and tirzepatide in type 2 diabetes, and aging-related biomarkers in diabetic nephropathy. The Special Issue also explores associations between serum cytokines and growth factors with time in range, as well as progression of diabetic kidney disease and gastrointestinal symptoms in subjects with type 1 diabetes. This new knowledge promises to enhance diagnosis, reduce the rate of progression of diabetes-related chronic complications, and may form the basis for future therapeutic approaches. |
| format | Online |
| id | doab-20.500.12854ir-174856 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1748562026-04-16T17:01:43Z Diabetes Bulum, Tomislav Diabetes GLP-1 RAs DPP-4is Cardiovascular risk Inflammation Diabetic nephropathy Aging Diagnostic biomarker Immune cell infiltration Molecular docking Autoimmune diabetes in adults Autoimmunity Glutamic acid decarboxylase autoantibodies Mycobacterium tuberculosis Tuberculosis meningitis Oxidative stress Type 1 diabetes Diabetic kidney disease Gastrointestinal symptoms Calprotectin Gastrointestinal endoscopy Insulin resistance Islet β cell Type 2 diabetes mellitus Gallbladder stone HbA1c Cytokines Growth factors Hyperglycemia Time in range Glucose variability Continuous glucose monitoring Ankle–brachial index Geriatric depression scale Depression Mortality Peripheral artery disease Type 2 diabetes Semaglutide Obesity Weight loss Overdose Underdose Off-label use EudraVigilance GLP-1 CRH Corticotropin releasing hormone receptor Norepinephrine Autonomous sympathetic nervous system Major depressive disorder HPA axis Stress Cortisol Deuterium-depleted water GLUT4 Diabetes management Once-weekly insulin GIP receptor agonists HbA1c reduction Treatment tolerability SGLT2i GLP1-RA Tirzepatide Comprehensive care approach Pharmacological therapies Gestational diabetes Neonatal outcomes Metformin Insulin Diet Prediabetes NHANES Mental health Blood glucose control Diabetic foot ulcers Osteomyelitis Wound care Wound dressings Material technologies User needs Pre-diabetes MAFLD Metabolic diseases Isthmin-1 Adipokines thema EDItEUR::M Medicine and Nursing Diabetes is one of the most challenging health problems in the 21st century, projected to affect 700 million people by 2045. In the last 15 years, the number of people diagnosed with type 1 diabetes increased by 45%, and those diagnosed with type 2 diabetes increased by 95%. The most devastating effects of diabetes are its chronic complications, which confer a high risk of morbidity and mortality and an increased health system cost burden. Although there is increased awareness and new therapeutic options in the treatment of diabetes, it is still the leading cause of blindness in working-age adults, the leading cause of kidney failure and dialysis, and the leading cause of nontraumatic lower-limb amputations. This Special Issue, featuring thirteen research articles, three reviews, and one systematic review, presents the latest knowledge of diabetes and its complications. Topics include the connection between circulating isthmin-1 levels and diabetes, material technologies for improved diabetic foot ulcer treatment, depression and stress in type 2 diabetes, metformin in gestational diabetes, safety of semaglutide and tirzepatide in type 2 diabetes, and aging-related biomarkers in diabetic nephropathy. The Special Issue also explores associations between serum cytokines and growth factors with time in range, as well as progression of diabetic kidney disease and gastrointestinal symptoms in subjects with type 1 diabetes. This new knowledge promises to enhance diagnosis, reduce the rate of progression of diabetes-related chronic complications, and may form the basis for future therapeutic approaches. 2026-04-16T17:01:35Z 2026-04-16T17:01:35Z 2025 book ONIX_20260416T142754_9783725855575_11 9783725855575 9783725855582 https://directory.doabooks.org/handle/20.500.12854/174856 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/ https://mdpi.com/books/pdfview/book/11736 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-5558-2 10.3390/books978-3-7258-5558-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725855575 9783725855582 266 CH open access |
| spellingShingle | Diabetes GLP-1 RAs DPP-4is Cardiovascular risk Inflammation Diabetic nephropathy Aging Diagnostic biomarker Immune cell infiltration Molecular docking Autoimmune diabetes in adults Autoimmunity Glutamic acid decarboxylase autoantibodies Mycobacterium tuberculosis Tuberculosis meningitis Oxidative stress Type 1 diabetes Diabetic kidney disease Gastrointestinal symptoms Calprotectin Gastrointestinal endoscopy Insulin resistance Islet β cell Type 2 diabetes mellitus Gallbladder stone HbA1c Cytokines Growth factors Hyperglycemia Time in range Glucose variability Continuous glucose monitoring Ankle–brachial index Geriatric depression scale Depression Mortality Peripheral artery disease Type 2 diabetes Semaglutide Obesity Weight loss Overdose Underdose Off-label use EudraVigilance GLP-1 CRH Corticotropin releasing hormone receptor Norepinephrine Autonomous sympathetic nervous system Major depressive disorder HPA axis Stress Cortisol Deuterium-depleted water GLUT4 Diabetes management Once-weekly insulin GIP receptor agonists HbA1c reduction Treatment tolerability SGLT2i GLP1-RA Tirzepatide Comprehensive care approach Pharmacological therapies Gestational diabetes Neonatal outcomes Metformin Insulin Diet Prediabetes NHANES Mental health Blood glucose control Diabetic foot ulcers Osteomyelitis Wound care Wound dressings Material technologies User needs Pre-diabetes MAFLD Metabolic diseases Isthmin-1 Adipokines thema EDItEUR::M Medicine and Nursing Diabetes |
| title | Diabetes |
| title_full | Diabetes |
| title_fullStr | Diabetes |
| title_full_unstemmed | Diabetes |
| title_short | Diabetes |
| title_sort | diabetes |
| topic | Diabetes GLP-1 RAs DPP-4is Cardiovascular risk Inflammation Diabetic nephropathy Aging Diagnostic biomarker Immune cell infiltration Molecular docking Autoimmune diabetes in adults Autoimmunity Glutamic acid decarboxylase autoantibodies Mycobacterium tuberculosis Tuberculosis meningitis Oxidative stress Type 1 diabetes Diabetic kidney disease Gastrointestinal symptoms Calprotectin Gastrointestinal endoscopy Insulin resistance Islet β cell Type 2 diabetes mellitus Gallbladder stone HbA1c Cytokines Growth factors Hyperglycemia Time in range Glucose variability Continuous glucose monitoring Ankle–brachial index Geriatric depression scale Depression Mortality Peripheral artery disease Type 2 diabetes Semaglutide Obesity Weight loss Overdose Underdose Off-label use EudraVigilance GLP-1 CRH Corticotropin releasing hormone receptor Norepinephrine Autonomous sympathetic nervous system Major depressive disorder HPA axis Stress Cortisol Deuterium-depleted water GLUT4 Diabetes management Once-weekly insulin GIP receptor agonists HbA1c reduction Treatment tolerability SGLT2i GLP1-RA Tirzepatide Comprehensive care approach Pharmacological therapies Gestational diabetes Neonatal outcomes Metformin Insulin Diet Prediabetes NHANES Mental health Blood glucose control Diabetic foot ulcers Osteomyelitis Wound care Wound dressings Material technologies User needs Pre-diabetes MAFLD Metabolic diseases Isthmin-1 Adipokines thema EDItEUR::M Medicine and Nursing |
| topic_facet | Diabetes GLP-1 RAs DPP-4is Cardiovascular risk Inflammation Diabetic nephropathy Aging Diagnostic biomarker Immune cell infiltration Molecular docking Autoimmune diabetes in adults Autoimmunity Glutamic acid decarboxylase autoantibodies Mycobacterium tuberculosis Tuberculosis meningitis Oxidative stress Type 1 diabetes Diabetic kidney disease Gastrointestinal symptoms Calprotectin Gastrointestinal endoscopy Insulin resistance Islet β cell Type 2 diabetes mellitus Gallbladder stone HbA1c Cytokines Growth factors Hyperglycemia Time in range Glucose variability Continuous glucose monitoring Ankle–brachial index Geriatric depression scale Depression Mortality Peripheral artery disease Type 2 diabetes Semaglutide Obesity Weight loss Overdose Underdose Off-label use EudraVigilance GLP-1 CRH Corticotropin releasing hormone receptor Norepinephrine Autonomous sympathetic nervous system Major depressive disorder HPA axis Stress Cortisol Deuterium-depleted water GLUT4 Diabetes management Once-weekly insulin GIP receptor agonists HbA1c reduction Treatment tolerability SGLT2i GLP1-RA Tirzepatide Comprehensive care approach Pharmacological therapies Gestational diabetes Neonatal outcomes Metformin Insulin Diet Prediabetes NHANES Mental health Blood glucose control Diabetic foot ulcers Osteomyelitis Wound care Wound dressings Material technologies User needs Pre-diabetes MAFLD Metabolic diseases Isthmin-1 Adipokines thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20260416T142754_9783725855575_11 |