Cellular and Molecular Mechanisms in Immune Regulation
This is a Reprint of the first edition of the Special Issue on "Cellular and Molecular Mechanisms in Immune Regulation” published by the journal Cells in 2024–2025. The reprint starts with a review of the latest advances in molecular mechanisms of immunity and the effect of X chromosome loss in immu...
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| Định dạng: | Online |
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| Ngôn ngữ: | Tiếng Anh |
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MDPI - Multidisciplinary Digital Publishing Institute
2026
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| Những chủ đề: | |
| Truy cập trực tuyến: | ONIX_20260416T142754_9783725858057_41 |
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| _version_ | 1869527754561552384 |
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| collection | Directory of Open Access Books |
| description | This is a Reprint of the first edition of the Special Issue on "Cellular and Molecular Mechanisms in Immune Regulation” published by the journal Cells in 2024–2025. The reprint starts with a review of the latest advances in molecular mechanisms of immunity and the effect of X chromosome loss in immune function. Next, we focus on autoimmunity by exploring the use of circular RNAs as biomarkers in multiple sclerosis and the role of circulating T cell subsets in Type 1 diabetes. We conclude reviewing the part played by lipid biosynthesis metabolism in the inflammatory response mediated by microglia in neurodegeneration and wound healing in the central nervous system. The importance of Immune regulation for preventive medicine is highlighted by a review on the interactions of T follicular helper cells and B cells and their role in the control of viral infections and vaccine design. Next, we explore how immune cell populations affect the prognosis of cancer patients treated by Immunotherapy using immune check point inhibitors. We conclude this part with an emphasis on tissue resident memory T cells (TRMs) and their potential in the control of cancer metastasis. The Special Issue concludes with articles highlighting the interactions between the environment and the immune system, specifically on the generation of tolerogenic dendritic cells mediated by oxygen tension in tissues and exposure to ultraviolet light (UV) on the skin. Thus, this reprint provides a glimpse of the multi-cellular immunoregulatory networks implicated in autoimmune diseases, infection and cancer as well as during normal interactions with the environment. |
| format | Online |
| id | doab-20.500.12854ir-174986 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1749862026-04-16T18:03:23Z Cellular and Molecular Mechanisms in Immune Regulation Santori, Fábio Rinaldo Ivanova, Natalia B. Circular RNAs Multiple sclerosis Biomarkers New diagnosis Immune regulation Immune cell infiltration Immune response Melanoma RNA expression Ovarian cancer Pancreatic cancer Bladder cancer T-cell Type 1 diabetes PD1 PRL T cells Turner syndrome X chromosome inactivation Autoimmunity Gene expression Single-cell RNA analysis Immune checkpoints Cytokine signaling Epigenetic modifications Non-coding RNAs Regulatory T cells (Tregs) Ultraviolet radiation Skin Tolerogenic dendritic cells Immunology Immunosuppression Viral infections Tfh cells MRNA vaccine Ferritin Germinal centers B cells Dendritic cells Microenvironment Oxygen Immunometabolism Dendritic-cell based immunotherapy Regulatory B cell B10 cells Macrophage PD-1 SPMs Lipid droplets Microglia Neurodegeneration Lipid metabolism Lipid droplet analytical tools Tissue-resident memory T (TRM) cells Cancer Metastasis Cancer therapy N A thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences This is a Reprint of the first edition of the Special Issue on "Cellular and Molecular Mechanisms in Immune Regulation” published by the journal Cells in 2024–2025. The reprint starts with a review of the latest advances in molecular mechanisms of immunity and the effect of X chromosome loss in immune function. Next, we focus on autoimmunity by exploring the use of circular RNAs as biomarkers in multiple sclerosis and the role of circulating T cell subsets in Type 1 diabetes. We conclude reviewing the part played by lipid biosynthesis metabolism in the inflammatory response mediated by microglia in neurodegeneration and wound healing in the central nervous system. The importance of Immune regulation for preventive medicine is highlighted by a review on the interactions of T follicular helper cells and B cells and their role in the control of viral infections and vaccine design. Next, we explore how immune cell populations affect the prognosis of cancer patients treated by Immunotherapy using immune check point inhibitors. We conclude this part with an emphasis on tissue resident memory T cells (TRMs) and their potential in the control of cancer metastasis. The Special Issue concludes with articles highlighting the interactions between the environment and the immune system, specifically on the generation of tolerogenic dendritic cells mediated by oxygen tension in tissues and exposure to ultraviolet light (UV) on the skin. Thus, this reprint provides a glimpse of the multi-cellular immunoregulatory networks implicated in autoimmune diseases, infection and cancer as well as during normal interactions with the environment. 2026-04-16T18:03:18Z 2026-04-16T18:03:18Z 2025 book ONIX_20260416T142754_9783725858057_41 9783725858057 9783725858064 https://directory.doabooks.org/handle/20.500.12854/174986 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/ https://mdpi.com/books/pdfview/book/11885 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-5806-4 10.3390/books978-3-7258-5806-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725858057 9783725858064 234 CH open access |
| spellingShingle | Circular RNAs Multiple sclerosis Biomarkers New diagnosis Immune regulation Immune cell infiltration Immune response Melanoma RNA expression Ovarian cancer Pancreatic cancer Bladder cancer T-cell Type 1 diabetes PD1 PRL T cells Turner syndrome X chromosome inactivation Autoimmunity Gene expression Single-cell RNA analysis Immune checkpoints Cytokine signaling Epigenetic modifications Non-coding RNAs Regulatory T cells (Tregs) Ultraviolet radiation Skin Tolerogenic dendritic cells Immunology Immunosuppression Viral infections Tfh cells MRNA vaccine Ferritin Germinal centers B cells Dendritic cells Microenvironment Oxygen Immunometabolism Dendritic-cell based immunotherapy Regulatory B cell B10 cells Macrophage PD-1 SPMs Lipid droplets Microglia Neurodegeneration Lipid metabolism Lipid droplet analytical tools Tissue-resident memory T (TRM) cells Cancer Metastasis Cancer therapy N A thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Cellular and Molecular Mechanisms in Immune Regulation |
| title | Cellular and Molecular Mechanisms in Immune Regulation |
| title_full | Cellular and Molecular Mechanisms in Immune Regulation |
| title_fullStr | Cellular and Molecular Mechanisms in Immune Regulation |
| title_full_unstemmed | Cellular and Molecular Mechanisms in Immune Regulation |
| title_short | Cellular and Molecular Mechanisms in Immune Regulation |
| title_sort | cellular and molecular mechanisms in immune regulation |
| topic | Circular RNAs Multiple sclerosis Biomarkers New diagnosis Immune regulation Immune cell infiltration Immune response Melanoma RNA expression Ovarian cancer Pancreatic cancer Bladder cancer T-cell Type 1 diabetes PD1 PRL T cells Turner syndrome X chromosome inactivation Autoimmunity Gene expression Single-cell RNA analysis Immune checkpoints Cytokine signaling Epigenetic modifications Non-coding RNAs Regulatory T cells (Tregs) Ultraviolet radiation Skin Tolerogenic dendritic cells Immunology Immunosuppression Viral infections Tfh cells MRNA vaccine Ferritin Germinal centers B cells Dendritic cells Microenvironment Oxygen Immunometabolism Dendritic-cell based immunotherapy Regulatory B cell B10 cells Macrophage PD-1 SPMs Lipid droplets Microglia Neurodegeneration Lipid metabolism Lipid droplet analytical tools Tissue-resident memory T (TRM) cells Cancer Metastasis Cancer therapy N A thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | Circular RNAs Multiple sclerosis Biomarkers New diagnosis Immune regulation Immune cell infiltration Immune response Melanoma RNA expression Ovarian cancer Pancreatic cancer Bladder cancer T-cell Type 1 diabetes PD1 PRL T cells Turner syndrome X chromosome inactivation Autoimmunity Gene expression Single-cell RNA analysis Immune checkpoints Cytokine signaling Epigenetic modifications Non-coding RNAs Regulatory T cells (Tregs) Ultraviolet radiation Skin Tolerogenic dendritic cells Immunology Immunosuppression Viral infections Tfh cells MRNA vaccine Ferritin Germinal centers B cells Dendritic cells Microenvironment Oxygen Immunometabolism Dendritic-cell based immunotherapy Regulatory B cell B10 cells Macrophage PD-1 SPMs Lipid droplets Microglia Neurodegeneration Lipid metabolism Lipid droplet analytical tools Tissue-resident memory T (TRM) cells Cancer Metastasis Cancer therapy N A thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20260416T142754_9783725858057_41 |