Peroxisome Proliferator-Activated Receptors (PPARs)
Prof. Walter Wahli devoted much of his career to exploring and defining the functions of Peroxisome Proliferator-Activated Receptors (PPARs). More than 25 years ago, his group began searching for new members of the nuclear hormone receptor superfamily using the DNA-binding domain of the estrogen rec...
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| Format: | Online |
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| Idioma: | anglès |
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MDPI - Multidisciplinary Digital Publishing Institute
2026
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| Accés en línia: | ONIX_20260416T142754_9783725855292_46 |
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| description | Prof. Walter Wahli devoted much of his career to exploring and defining the functions of Peroxisome Proliferator-Activated Receptors (PPARs). More than 25 years ago, his group began searching for new members of the nuclear hormone receptor superfamily using the DNA-binding domain of the estrogen receptor as a probe. This led to the discovery of novel receptors, now known as PPARα, β, and γ. While PPARα was independently first published by Isabelle Issemann and Stephen Green, Prof. Wahli and colleagues went on to characterize all three isotypes of this receptor family. Building on this pioneering work, Prof. Wahli and his collaborators revealed how PPARs are activated by fatty acids and regulate gene expression in metabolic and physiological pathways. Their findings, notably that fatty acids can act via nuclear receptor-mediated mechanisms similar to hormones, reshaped the understanding of metabolism and opened new therapeutic possibilities using synthetic compounds. Prof. Wahli’s vision and scientific rigor greatly enriched the knowledge of PPAR biology and inspired many researchers worldwide. His enduring legacy illustrates the transformative power of scientific inquiry and its potential to improve human health. |
| format | Online |
| id | doab-20.500.12854ir-174991 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1749912026-04-16T18:04:38Z Peroxisome Proliferator-Activated Receptors (PPARs) Guillou, Hervé Vázquez-Carrera, Manuel PPAR Nuclear receptors Metabolism Gene regulation Physiology thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Prof. Walter Wahli devoted much of his career to exploring and defining the functions of Peroxisome Proliferator-Activated Receptors (PPARs). More than 25 years ago, his group began searching for new members of the nuclear hormone receptor superfamily using the DNA-binding domain of the estrogen receptor as a probe. This led to the discovery of novel receptors, now known as PPARα, β, and γ. While PPARα was independently first published by Isabelle Issemann and Stephen Green, Prof. Wahli and colleagues went on to characterize all three isotypes of this receptor family. Building on this pioneering work, Prof. Wahli and his collaborators revealed how PPARs are activated by fatty acids and regulate gene expression in metabolic and physiological pathways. Their findings, notably that fatty acids can act via nuclear receptor-mediated mechanisms similar to hormones, reshaped the understanding of metabolism and opened new therapeutic possibilities using synthetic compounds. Prof. Wahli’s vision and scientific rigor greatly enriched the knowledge of PPAR biology and inspired many researchers worldwide. His enduring legacy illustrates the transformative power of scientific inquiry and its potential to improve human health. 2026-04-16T18:04:30Z 2026-04-16T18:04:30Z 2025 book ONIX_20260416T142754_9783725855292_46 9783725855292 9783725855308 https://directory.doabooks.org/handle/20.500.12854/174991 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/ https://mdpi.com/books/pdfview/book/11890 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-5530-8 10.3390/books978-3-7258-5530-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725855292 9783725855308 206 CH open access |
| spellingShingle | PPAR Nuclear receptors Metabolism Gene regulation Physiology thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Peroxisome Proliferator-Activated Receptors (PPARs) |
| title | Peroxisome Proliferator-Activated Receptors (PPARs) |
| title_full | Peroxisome Proliferator-Activated Receptors (PPARs) |
| title_fullStr | Peroxisome Proliferator-Activated Receptors (PPARs) |
| title_full_unstemmed | Peroxisome Proliferator-Activated Receptors (PPARs) |
| title_short | Peroxisome Proliferator-Activated Receptors (PPARs) |
| title_sort | peroxisome proliferator activated receptors ppars |
| topic | PPAR Nuclear receptors Metabolism Gene regulation Physiology thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | PPAR Nuclear receptors Metabolism Gene regulation Physiology thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20260416T142754_9783725855292_46 |