Advances in Plant-Sourced Natural Compounds as Anticancer Agents
Cancer remains one of the leading causes of death worldwide, particularly in countries with higher life expectancy, education levels, and standards of living, despite significant advances in early detection and treatment over recent decades. As a result, there is growing interest in exploring altern...
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| Format: | Online |
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| Jezik: | angleščina |
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MDPI - Multidisciplinary Digital Publishing Institute
2026
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| Online dostop: | ONIX_20260416T142754_9783725864508_5 |
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| description | Cancer remains one of the leading causes of death worldwide, particularly in countries with higher life expectancy, education levels, and standards of living, despite significant advances in early detection and treatment over recent decades. As a result, there is growing interest in exploring alternative and complementary strategies, such as the use of natural compounds as adjuvant therapies, to improve patient outcomes. The plant world has emerged as a rich source of bioactive molecules for the discovery and development of new anticancer drugs. Several plant metabolites have served as lead structures for the development of FDA-approved chemotherapeutics. Research into medicinal plants continues to grow because novel therapeutics derived from them offer the promise of more effective, less toxic treatment options for patients, particularly when conventional therapies are limited by resistance or intolerable side effects. Plant extracts and isolated phytochemicals have demonstrated strong potential to improve the clinical outcomes of cancer patients, as evidenced by a growing body of preclinical and clinical research. In addition to direct cytotoxic effects, many phytochemicals modulate key signaling pathways involved in tumor growth, metastasis, and immune evasion. They may enhance the sensitivity of cancer cells to existing treatments. |
| format | Online |
| id | doab-20.500.12854ir-175200 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1752002026-04-16T19:33:08Z Advances in Plant-Sourced Natural Compounds as Anticancer Agents Popovici, Violeta Ozon, Emma Adriana Gîrd, Cerasela Elena Lupuliasa, Dumitru Fucoxanthin TNBC PI3K-AKT signaling pathway Tumor microenvironment Cordycepin derivatives Antitumor Structural modification Curcuma wenyujin Curcumenol Biological activity TCM Berberis vulgaris (L.) stem bark Dry hydro-ethanolic extract Phenolic secondary metabolites Berberine Antioxidant activity Cytotoxicity Bicyclogermacrene Epi-bicyclosesquiphellandrene Anticancer activity Lantana camara Essential oil Chemical composition Γ-tocopherol Antioxidant Anti-inflammatory Anticancer Clinical trials Nanoformulations Anti-cancer effect MTT assay HaCat A5 cell lines II4 cell lines Juniperus excelsa M. Bieb. (Cupressaceae) Lavandula vera DC. (Lamiaceae) Salvia fruticosa Mill. (Lamiaceae) Laurus nobilis Breast cancer Ovarian cancer Colorectal cancer Head and neck cancer Apoptosis thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Cancer remains one of the leading causes of death worldwide, particularly in countries with higher life expectancy, education levels, and standards of living, despite significant advances in early detection and treatment over recent decades. As a result, there is growing interest in exploring alternative and complementary strategies, such as the use of natural compounds as adjuvant therapies, to improve patient outcomes. The plant world has emerged as a rich source of bioactive molecules for the discovery and development of new anticancer drugs. Several plant metabolites have served as lead structures for the development of FDA-approved chemotherapeutics. Research into medicinal plants continues to grow because novel therapeutics derived from them offer the promise of more effective, less toxic treatment options for patients, particularly when conventional therapies are limited by resistance or intolerable side effects. Plant extracts and isolated phytochemicals have demonstrated strong potential to improve the clinical outcomes of cancer patients, as evidenced by a growing body of preclinical and clinical research. In addition to direct cytotoxic effects, many phytochemicals modulate key signaling pathways involved in tumor growth, metastasis, and immune evasion. They may enhance the sensitivity of cancer cells to existing treatments. 2026-04-16T19:33:01Z 2026-04-16T19:33:01Z 2026 book ONIX_20260416T142754_9783725864508_5 9783725864508 9783725864515 https://directory.doabooks.org/handle/20.500.12854/175200 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/ https://mdpi.com/books/pdfview/book/12112 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-6451-5 10.3390/books978-3-7258-6451-5 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725864508 9783725864515 166 CH open access |
| spellingShingle | Fucoxanthin TNBC PI3K-AKT signaling pathway Tumor microenvironment Cordycepin derivatives Antitumor Structural modification Curcuma wenyujin Curcumenol Biological activity TCM Berberis vulgaris (L.) stem bark Dry hydro-ethanolic extract Phenolic secondary metabolites Berberine Antioxidant activity Cytotoxicity Bicyclogermacrene Epi-bicyclosesquiphellandrene Anticancer activity Lantana camara Essential oil Chemical composition Γ-tocopherol Antioxidant Anti-inflammatory Anticancer Clinical trials Nanoformulations Anti-cancer effect MTT assay HaCat A5 cell lines II4 cell lines Juniperus excelsa M. Bieb. (Cupressaceae) Lavandula vera DC. (Lamiaceae) Salvia fruticosa Mill. (Lamiaceae) Laurus nobilis Breast cancer Ovarian cancer Colorectal cancer Head and neck cancer Apoptosis thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Advances in Plant-Sourced Natural Compounds as Anticancer Agents |
| title | Advances in Plant-Sourced Natural Compounds as Anticancer Agents |
| title_full | Advances in Plant-Sourced Natural Compounds as Anticancer Agents |
| title_fullStr | Advances in Plant-Sourced Natural Compounds as Anticancer Agents |
| title_full_unstemmed | Advances in Plant-Sourced Natural Compounds as Anticancer Agents |
| title_short | Advances in Plant-Sourced Natural Compounds as Anticancer Agents |
| title_sort | advances in plant sourced natural compounds as anticancer agents |
| topic | Fucoxanthin TNBC PI3K-AKT signaling pathway Tumor microenvironment Cordycepin derivatives Antitumor Structural modification Curcuma wenyujin Curcumenol Biological activity TCM Berberis vulgaris (L.) stem bark Dry hydro-ethanolic extract Phenolic secondary metabolites Berberine Antioxidant activity Cytotoxicity Bicyclogermacrene Epi-bicyclosesquiphellandrene Anticancer activity Lantana camara Essential oil Chemical composition Γ-tocopherol Antioxidant Anti-inflammatory Anticancer Clinical trials Nanoformulations Anti-cancer effect MTT assay HaCat A5 cell lines II4 cell lines Juniperus excelsa M. Bieb. (Cupressaceae) Lavandula vera DC. (Lamiaceae) Salvia fruticosa Mill. (Lamiaceae) Laurus nobilis Breast cancer Ovarian cancer Colorectal cancer Head and neck cancer Apoptosis thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | Fucoxanthin TNBC PI3K-AKT signaling pathway Tumor microenvironment Cordycepin derivatives Antitumor Structural modification Curcuma wenyujin Curcumenol Biological activity TCM Berberis vulgaris (L.) stem bark Dry hydro-ethanolic extract Phenolic secondary metabolites Berberine Antioxidant activity Cytotoxicity Bicyclogermacrene Epi-bicyclosesquiphellandrene Anticancer activity Lantana camara Essential oil Chemical composition Γ-tocopherol Antioxidant Anti-inflammatory Anticancer Clinical trials Nanoformulations Anti-cancer effect MTT assay HaCat A5 cell lines II4 cell lines Juniperus excelsa M. Bieb. (Cupressaceae) Lavandula vera DC. (Lamiaceae) Salvia fruticosa Mill. (Lamiaceae) Laurus nobilis Breast cancer Ovarian cancer Colorectal cancer Head and neck cancer Apoptosis thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20260416T142754_9783725864508_5 |