Future Challenges for the Diagnosis and Management of Affective Disorders
This Special Issue presents preclinical and clinical research aimed at reframing the diagnosis and treatment of affective disorders beyond classical neurobiological models. It includes a meta-analysis comparing single- versus two-dose psilocybin administration in major depressive disorder, clarifyin...
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| Format: | Online |
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| Sprog: | engelsk |
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MDPI - Multidisciplinary Digital Publishing Institute
2026
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| Online adgang: | ONIX_20260416T142754_9783725860715_11 |
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| collection | Directory of Open Access Books |
| description | This Special Issue presents preclinical and clinical research aimed at reframing the diagnosis and treatment of affective disorders beyond classical neurobiological models. It includes a meta-analysis comparing single- versus two-dose psilocybin administration in major depressive disorder, clarifying its efficacy and dose-dependency. Another study uses network analysis of exposome scores to link environmental exposure with multidimensional psychopathology in non-clinical samples, while the effects of light pollution on affective health highlight chronobiological disruption in mood disorder etiology. Diagnostic and clinical dimensions are explored through research on polarity at bipolar disorder onset, mapping temperamental correlates and long-term trajectories. Biomarker studies report elevated mature brain-derived neurotrophic factor (BDNF) levels associated with suicidal ideation in major depressive disorder and evaluate BDNF’s validity in bipolar disorder. Perinatal and familial aspects are explored in a structural equation modeling study showing how attachment-related coping mediates postpartum depressive symptoms and which develops a protocol for a randomized clinical trial for a psychoeducational family intervention in major depressive disorder. Together, these contributions outline a multidimensional landscape integrating environmental, temperamental, biological, and psychosocial determinants. |
| format | Online |
| id | doab-20.500.12854ir-175206 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1752062026-04-16T19:35:00Z Future Challenges for the Diagnosis and Management of Affective Disorders Ventriglio, Antonio Luciano, Mario Fiorillo, Andrea Perinatal depression Attachment style Coping strategies Gender medicine Structural equation modelling Family psychoeducation Major depression Caregiver Family burden Relapse rates Depressive symptoms Social contacts Brain-derived neurotrophic factor BDNF Bipolar disorder BDNF-TrkB signaling Inflammatory factors Suicidal ideation Beck Scale Major depressive disorder Polarity at onset Affective temperaments Manic Hypomanic polarity Depressive polarity Psychosis Mood disorder Depression Transdiagnostic psychiatry Early intervention Light pollution Artificial light at night Urbanization Mental health Circadian rhythms Mood disorders Psychopathology MDD Treatment-resistant depression TRD Psilocybin Psychedelics Psoriasis Quality of life Anxiety Affective disorders Psychiatric comorbidities N A thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences This Special Issue presents preclinical and clinical research aimed at reframing the diagnosis and treatment of affective disorders beyond classical neurobiological models. It includes a meta-analysis comparing single- versus two-dose psilocybin administration in major depressive disorder, clarifying its efficacy and dose-dependency. Another study uses network analysis of exposome scores to link environmental exposure with multidimensional psychopathology in non-clinical samples, while the effects of light pollution on affective health highlight chronobiological disruption in mood disorder etiology. Diagnostic and clinical dimensions are explored through research on polarity at bipolar disorder onset, mapping temperamental correlates and long-term trajectories. Biomarker studies report elevated mature brain-derived neurotrophic factor (BDNF) levels associated with suicidal ideation in major depressive disorder and evaluate BDNF’s validity in bipolar disorder. Perinatal and familial aspects are explored in a structural equation modeling study showing how attachment-related coping mediates postpartum depressive symptoms and which develops a protocol for a randomized clinical trial for a psychoeducational family intervention in major depressive disorder. Together, these contributions outline a multidimensional landscape integrating environmental, temperamental, biological, and psychosocial determinants. 2026-04-16T19:34:51Z 2026-04-16T19:34:51Z 2026 book ONIX_20260416T142754_9783725860715_11 9783725860715 9783725860722 https://directory.doabooks.org/handle/20.500.12854/175206 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/ https://mdpi.com/books/pdfview/book/12118 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-6072-2 10.3390/books978-3-7258-6072-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725860715 9783725860722 156 CH open access |
| spellingShingle | Perinatal depression Attachment style Coping strategies Gender medicine Structural equation modelling Family psychoeducation Major depression Caregiver Family burden Relapse rates Depressive symptoms Social contacts Brain-derived neurotrophic factor BDNF Bipolar disorder BDNF-TrkB signaling Inflammatory factors Suicidal ideation Beck Scale Major depressive disorder Polarity at onset Affective temperaments Manic Hypomanic polarity Depressive polarity Psychosis Mood disorder Depression Transdiagnostic psychiatry Early intervention Light pollution Artificial light at night Urbanization Mental health Circadian rhythms Mood disorders Psychopathology MDD Treatment-resistant depression TRD Psilocybin Psychedelics Psoriasis Quality of life Anxiety Affective disorders Psychiatric comorbidities N A thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Future Challenges for the Diagnosis and Management of Affective Disorders |
| title | Future Challenges for the Diagnosis and Management of Affective Disorders |
| title_full | Future Challenges for the Diagnosis and Management of Affective Disorders |
| title_fullStr | Future Challenges for the Diagnosis and Management of Affective Disorders |
| title_full_unstemmed | Future Challenges for the Diagnosis and Management of Affective Disorders |
| title_short | Future Challenges for the Diagnosis and Management of Affective Disorders |
| title_sort | future challenges for the diagnosis and management of affective disorders |
| topic | Perinatal depression Attachment style Coping strategies Gender medicine Structural equation modelling Family psychoeducation Major depression Caregiver Family burden Relapse rates Depressive symptoms Social contacts Brain-derived neurotrophic factor BDNF Bipolar disorder BDNF-TrkB signaling Inflammatory factors Suicidal ideation Beck Scale Major depressive disorder Polarity at onset Affective temperaments Manic Hypomanic polarity Depressive polarity Psychosis Mood disorder Depression Transdiagnostic psychiatry Early intervention Light pollution Artificial light at night Urbanization Mental health Circadian rhythms Mood disorders Psychopathology MDD Treatment-resistant depression TRD Psilocybin Psychedelics Psoriasis Quality of life Anxiety Affective disorders Psychiatric comorbidities N A thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | Perinatal depression Attachment style Coping strategies Gender medicine Structural equation modelling Family psychoeducation Major depression Caregiver Family burden Relapse rates Depressive symptoms Social contacts Brain-derived neurotrophic factor BDNF Bipolar disorder BDNF-TrkB signaling Inflammatory factors Suicidal ideation Beck Scale Major depressive disorder Polarity at onset Affective temperaments Manic Hypomanic polarity Depressive polarity Psychosis Mood disorder Depression Transdiagnostic psychiatry Early intervention Light pollution Artificial light at night Urbanization Mental health Circadian rhythms Mood disorders Psychopathology MDD Treatment-resistant depression TRD Psilocybin Psychedelics Psoriasis Quality of life Anxiety Affective disorders Psychiatric comorbidities N A thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | ONIX_20260416T142754_9783725860715_11 |