Nanoparticle-Mediated Targeted Drug Delivery Systems
In drug research and development, delivering drugs to the target sites is crucial to avoid serious off-target side effects and ensure effective medical treatment. Specifically, certain anti-cancer drugs exhibit their activity not only on cancer cells but also on normal cells, causing side effects su...
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| Formaat: | Online |
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| Taal: | Engels |
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MDPI - Multidisciplinary Digital Publishing Institute
2026
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| Online toegang: | ONIX_20260416T142754_9783725864706_22 |
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| description | In drug research and development, delivering drugs to the target sites is crucial to avoid serious off-target side effects and ensure effective medical treatment. Specifically, certain anti-cancer drugs exhibit their activity not only on cancer cells but also on normal cells, causing side effects such as nausea, skin disorders, or hair loss. Central nervous system drug candidates face challenges in penetrating the brain due to the blood–brain barrier. Furthermore, incorrect drug distribution can often lead to adverse events in terms of other diseases. Therefore, precision drug delivery should be enhanced and eventually established. The modification of nanoparticles is relatively straightforward. Consequently, a variety of useful nanoparticles can be produced for drug-controlled release, barrier permeation, including cell membranes, and/or targeting. Additionally, nanoparticles protect their cargos from degradation by enzymes and inhibit their unsuitable activity expression, reducing the risk of off-target side effects. Multiple strategies can be integrated into nanoparticles. Currently, pharmaceutical researchers and healthcare workers are increasingly interested in nanoparticle-mediated targeted drug delivery systems. Drug-loaded nanoparticles are employed differently based on the purpose and target area. Drug delivery systems utilizing nanoparticles as carriers represent promising strategies for achieving intelligent drug distribution. |
| format | Online |
| id | doab-20.500.12854ir-175267 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1752672026-04-16T19:58:15Z Nanoparticle-Mediated Targeted Drug Delivery Systems Tournier, Nicolas Tashima, Toshihiko Drug delivery system Nanodelivery system Nanoparticle Receptor-mediated endocytosis Transcytosis Enhanced permeability and retention effect (EPR effect) Cancer therapy Central nervous system disease therapy Liposomes Exosomes RNA delivery thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences In drug research and development, delivering drugs to the target sites is crucial to avoid serious off-target side effects and ensure effective medical treatment. Specifically, certain anti-cancer drugs exhibit their activity not only on cancer cells but also on normal cells, causing side effects such as nausea, skin disorders, or hair loss. Central nervous system drug candidates face challenges in penetrating the brain due to the blood–brain barrier. Furthermore, incorrect drug distribution can often lead to adverse events in terms of other diseases. Therefore, precision drug delivery should be enhanced and eventually established. The modification of nanoparticles is relatively straightforward. Consequently, a variety of useful nanoparticles can be produced for drug-controlled release, barrier permeation, including cell membranes, and/or targeting. Additionally, nanoparticles protect their cargos from degradation by enzymes and inhibit their unsuitable activity expression, reducing the risk of off-target side effects. Multiple strategies can be integrated into nanoparticles. Currently, pharmaceutical researchers and healthcare workers are increasingly interested in nanoparticle-mediated targeted drug delivery systems. Drug-loaded nanoparticles are employed differently based on the purpose and target area. Drug delivery systems utilizing nanoparticles as carriers represent promising strategies for achieving intelligent drug distribution. 2026-04-16T19:58:08Z 2026-04-16T19:58:08Z 2026 book ONIX_20260416T142754_9783725864706_22 9783725864706 9783725864713 https://directory.doabooks.org/handle/20.500.12854/175267 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/ https://mdpi.com/books/pdfview/book/12179 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-6471-3 10.3390/books978-3-7258-6471-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725864706 9783725864713 246 CH open access |
| spellingShingle | Drug delivery system Nanodelivery system Nanoparticle Receptor-mediated endocytosis Transcytosis Enhanced permeability and retention effect (EPR effect) Cancer therapy Central nervous system disease therapy Liposomes Exosomes RNA delivery thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Nanoparticle-Mediated Targeted Drug Delivery Systems |
| title | Nanoparticle-Mediated Targeted Drug Delivery Systems |
| title_full | Nanoparticle-Mediated Targeted Drug Delivery Systems |
| title_fullStr | Nanoparticle-Mediated Targeted Drug Delivery Systems |
| title_full_unstemmed | Nanoparticle-Mediated Targeted Drug Delivery Systems |
| title_short | Nanoparticle-Mediated Targeted Drug Delivery Systems |
| title_sort | nanoparticle mediated targeted drug delivery systems |
| topic | Drug delivery system Nanodelivery system Nanoparticle Receptor-mediated endocytosis Transcytosis Enhanced permeability and retention effect (EPR effect) Cancer therapy Central nervous system disease therapy Liposomes Exosomes RNA delivery thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | Drug delivery system Nanodelivery system Nanoparticle Receptor-mediated endocytosis Transcytosis Enhanced permeability and retention effect (EPR effect) Cancer therapy Central nervous system disease therapy Liposomes Exosomes RNA delivery thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20260416T142754_9783725864706_22 |