Adenovirus Cell and Immune Interactions

Ever since their discovery in the early 1950s, human adenoviruses (HAdVs), the cause of respiratory diseases of young children, have been the subject of intense basic research as well as efforts to engineer HAdV vectors to ameliorate human diseases. Although much information has been gleaned over th...

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collection Directory of Open Access Books
description Ever since their discovery in the early 1950s, human adenoviruses (HAdVs), the cause of respiratory diseases of young children, have been the subject of intense basic research as well as efforts to engineer HAdV vectors to ameliorate human diseases. Although much information has been gleaned over the past 67 years from laboratory and clinical investigations, we still have an incomplete picture of the critical associations of HAdV with host cells and specific components of the immune system. An ability to uncover additional information will likely influence the future success (or failure) for exploiting HAdV vectors for gene and vaccine therapies. Each contribution in this series will highlight the efforts and progress made to acquire basic knowledge of adenovirus host interactions and will indicate particular areas that remain to be uncovered. Topics in this new series include key steps in HAdV–host cell interactions as well as structure-based investigations of virus and virus capsid protein associations with cell receptors and innate immune molecules. These topics will culminate with discussions on examples of HAdV vector design and how these approaches are influenced by the accumulation of knowledge of host–vector interactions.
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publisherStr MDPI - Multidisciplinary Digital Publishing Institute
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spelling doab-20.500.12854ir-1753182026-04-16T20:13:06Z Adenovirus Cell and Immune Interactions Nemerow, Glen R. Adenovirus Gene therapy Vaccine Immune system Respiratory disease Structure thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Ever since their discovery in the early 1950s, human adenoviruses (HAdVs), the cause of respiratory diseases of young children, have been the subject of intense basic research as well as efforts to engineer HAdV vectors to ameliorate human diseases. Although much information has been gleaned over the past 67 years from laboratory and clinical investigations, we still have an incomplete picture of the critical associations of HAdV with host cells and specific components of the immune system. An ability to uncover additional information will likely influence the future success (or failure) for exploiting HAdV vectors for gene and vaccine therapies. Each contribution in this series will highlight the efforts and progress made to acquire basic knowledge of adenovirus host interactions and will indicate particular areas that remain to be uncovered. Topics in this new series include key steps in HAdV–host cell interactions as well as structure-based investigations of virus and virus capsid protein associations with cell receptors and innate immune molecules. These topics will culminate with discussions on examples of HAdV vector design and how these approaches are influenced by the accumulation of knowledge of host–vector interactions. 2026-04-16T20:12:58Z 2026-04-16T20:12:58Z 2026 book ONIX_20260416T142754_9783725866045_23 9783725866045 9783725866052 https://directory.doabooks.org/handle/20.500.12854/175318 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/ https://mdpi.com/books/pdfview/book/12231 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-6605-2 10.3390/books978-3-7258-6605-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725866045 9783725866052 186 CH open access
spellingShingle Adenovirus
Gene therapy
Vaccine
Immune system
Respiratory disease
Structure
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
Adenovirus Cell and Immune Interactions
title Adenovirus Cell and Immune Interactions
title_full Adenovirus Cell and Immune Interactions
title_fullStr Adenovirus Cell and Immune Interactions
title_full_unstemmed Adenovirus Cell and Immune Interactions
title_short Adenovirus Cell and Immune Interactions
title_sort adenovirus cell and immune interactions
topic Adenovirus
Gene therapy
Vaccine
Immune system
Respiratory disease
Structure
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
topic_facet Adenovirus
Gene therapy
Vaccine
Immune system
Respiratory disease
Structure
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
url ONIX_20260416T142754_9783725866045_23