Oncogenesis of Lymphoma
This Special Issue on the topic of the oncogenesis of lymphoma focuses on three major areas of research: viral oncogenesis, molecular mechanisms of transformation, and putative microbial drivers. The section on viral oncogenesis highlights the role of the Epstein–Barr virus (EBV) and Kaposi sarcoma-...
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| Materialtyp: | Online |
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| Språk: | engelska |
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MDPI - Multidisciplinary Digital Publishing Institute
2026
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| Länkar: | ONIX_20260416T142754_9783725866847_29 |
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| _version_ | 1869527874982117376 |
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| collection | Directory of Open Access Books |
| description | This Special Issue on the topic of the oncogenesis of lymphoma focuses on three major areas of research: viral oncogenesis, molecular mechanisms of transformation, and putative microbial drivers. The section on viral oncogenesis highlights the role of the Epstein–Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) in lymphoid malignancies. Contributions discuss EBV-positive classic Hodgkin lymphoma in immunodeficient hosts, the interplay between EBV and MYC in Burkitt lymphoma, and KSHV-mediated signaling alterations in primary effusion lymphoma and multicentric Castleman disease. Another review addresses lymphoproliferative disorders in people living with HIV, examining clinical heterogeneity and emerging immunotherapeutic strategies. The molecular transformation section examines the progression of indolent B-cell malignancies to aggressive lymphomas, emphasizing genetic lesions and immune dysregulation. Additional articles explore the relevance of TNF family receptors in classic Hodgkin lymphoma, the impact of c-MYC overexpression and IGH rearrangements in chronic lymphocytic leukemia, and integrated genomic–TCR profiling to refine diagnosis and prognosis in early mycosis fungoides. Finally, studies on putative microbial drivers investigate the contribution of skin dysbiosis—particularly toxin-producing Staphylococcus aureus—to T-cell activation in mycosis fungoides, and microbiome features in breast implant-associated anaplastic large cell lymphoma, supporting multifactorial rather than pathogen-specific etiologies. |
| format | Online |
| id | doab-20.500.12854ir-175374 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1753742026-04-16T20:32:10Z Oncogenesis of Lymphoma Gloghini, Annunziata Pruneri, Giancarlo Kaposi sarcoma-associated herpesvirus KSHV HHV8 Lymphoma Lymphomagenesis Viral oncogenesis MYC CLL Recombination DNA repair B cell Cutaneous T cell lymphoma (CTCL) Mycosis fungoides (MF) Microbiome Transcriptomics Multi-omics Data integration Bioinformatics Computational biology Disease signalling NF-κB IL-1B Staphylococcus aureus Protein A Microbiome-driven pathogenesis TNF family CD40 CD30 Classic Hodgkin lymphoma Tumor microenvironment Pathobiology New therapies Epstein–Barr virus Burkitt lymphoma CTCL T-cell receptor Diagnostic Genomic aberrations Sequencing Chronic lymphocytic leukemia Follicular lymphoma Lymphoplasmacytic lymphoma Marginal zone lymphoma Richter transformation Diffuse large B cell lymphoma Histological transformation EBV+ cHL WHO classification Immune deficiency Immune dysregulation Management Diagnosis Human immunodeficiency virus Lymphomas Kaposi’s sarcoma-associated herpesvirus Combined antiretroviral therapy Immunotherapy BIA-ALCL NGS thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences This Special Issue on the topic of the oncogenesis of lymphoma focuses on three major areas of research: viral oncogenesis, molecular mechanisms of transformation, and putative microbial drivers. The section on viral oncogenesis highlights the role of the Epstein–Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) in lymphoid malignancies. Contributions discuss EBV-positive classic Hodgkin lymphoma in immunodeficient hosts, the interplay between EBV and MYC in Burkitt lymphoma, and KSHV-mediated signaling alterations in primary effusion lymphoma and multicentric Castleman disease. Another review addresses lymphoproliferative disorders in people living with HIV, examining clinical heterogeneity and emerging immunotherapeutic strategies. The molecular transformation section examines the progression of indolent B-cell malignancies to aggressive lymphomas, emphasizing genetic lesions and immune dysregulation. Additional articles explore the relevance of TNF family receptors in classic Hodgkin lymphoma, the impact of c-MYC overexpression and IGH rearrangements in chronic lymphocytic leukemia, and integrated genomic–TCR profiling to refine diagnosis and prognosis in early mycosis fungoides. Finally, studies on putative microbial drivers investigate the contribution of skin dysbiosis—particularly toxin-producing Staphylococcus aureus—to T-cell activation in mycosis fungoides, and microbiome features in breast implant-associated anaplastic large cell lymphoma, supporting multifactorial rather than pathogen-specific etiologies. 2026-04-16T20:32:03Z 2026-04-16T20:32:03Z 2026 book ONIX_20260416T142754_9783725866847_29 9783725866847 9783725866854 https://directory.doabooks.org/handle/20.500.12854/175374 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/ https://mdpi.com/books/pdfview/book/12289 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-6685-4 10.3390/books978-3-7258-6685-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725866847 9783725866854 214 CH open access |
| spellingShingle | Kaposi sarcoma-associated herpesvirus KSHV HHV8 Lymphoma Lymphomagenesis Viral oncogenesis MYC CLL Recombination DNA repair B cell Cutaneous T cell lymphoma (CTCL) Mycosis fungoides (MF) Microbiome Transcriptomics Multi-omics Data integration Bioinformatics Computational biology Disease signalling NF-κB IL-1B Staphylococcus aureus Protein A Microbiome-driven pathogenesis TNF family CD40 CD30 Classic Hodgkin lymphoma Tumor microenvironment Pathobiology New therapies Epstein–Barr virus Burkitt lymphoma CTCL T-cell receptor Diagnostic Genomic aberrations Sequencing Chronic lymphocytic leukemia Follicular lymphoma Lymphoplasmacytic lymphoma Marginal zone lymphoma Richter transformation Diffuse large B cell lymphoma Histological transformation EBV+ cHL WHO classification Immune deficiency Immune dysregulation Management Diagnosis Human immunodeficiency virus Lymphomas Kaposi’s sarcoma-associated herpesvirus Combined antiretroviral therapy Immunotherapy BIA-ALCL NGS thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Oncogenesis of Lymphoma |
| title | Oncogenesis of Lymphoma |
| title_full | Oncogenesis of Lymphoma |
| title_fullStr | Oncogenesis of Lymphoma |
| title_full_unstemmed | Oncogenesis of Lymphoma |
| title_short | Oncogenesis of Lymphoma |
| title_sort | oncogenesis of lymphoma |
| topic | Kaposi sarcoma-associated herpesvirus KSHV HHV8 Lymphoma Lymphomagenesis Viral oncogenesis MYC CLL Recombination DNA repair B cell Cutaneous T cell lymphoma (CTCL) Mycosis fungoides (MF) Microbiome Transcriptomics Multi-omics Data integration Bioinformatics Computational biology Disease signalling NF-κB IL-1B Staphylococcus aureus Protein A Microbiome-driven pathogenesis TNF family CD40 CD30 Classic Hodgkin lymphoma Tumor microenvironment Pathobiology New therapies Epstein–Barr virus Burkitt lymphoma CTCL T-cell receptor Diagnostic Genomic aberrations Sequencing Chronic lymphocytic leukemia Follicular lymphoma Lymphoplasmacytic lymphoma Marginal zone lymphoma Richter transformation Diffuse large B cell lymphoma Histological transformation EBV+ cHL WHO classification Immune deficiency Immune dysregulation Management Diagnosis Human immunodeficiency virus Lymphomas Kaposi’s sarcoma-associated herpesvirus Combined antiretroviral therapy Immunotherapy BIA-ALCL NGS thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | Kaposi sarcoma-associated herpesvirus KSHV HHV8 Lymphoma Lymphomagenesis Viral oncogenesis MYC CLL Recombination DNA repair B cell Cutaneous T cell lymphoma (CTCL) Mycosis fungoides (MF) Microbiome Transcriptomics Multi-omics Data integration Bioinformatics Computational biology Disease signalling NF-κB IL-1B Staphylococcus aureus Protein A Microbiome-driven pathogenesis TNF family CD40 CD30 Classic Hodgkin lymphoma Tumor microenvironment Pathobiology New therapies Epstein–Barr virus Burkitt lymphoma CTCL T-cell receptor Diagnostic Genomic aberrations Sequencing Chronic lymphocytic leukemia Follicular lymphoma Lymphoplasmacytic lymphoma Marginal zone lymphoma Richter transformation Diffuse large B cell lymphoma Histological transformation EBV+ cHL WHO classification Immune deficiency Immune dysregulation Management Diagnosis Human immunodeficiency virus Lymphomas Kaposi’s sarcoma-associated herpesvirus Combined antiretroviral therapy Immunotherapy BIA-ALCL NGS thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20260416T142754_9783725866847_29 |