Application of Membrane Materials in Bioseparation and Downstream Processing
Membrane technologies play an instrumental role in bioseparation and downstream processing. Membrane operations such as microfiltration, ultrafiltration, and virus filtration are key tools for clarification, concentration, buffer exchange, and viral clearance in biomanufacturing, as they offer mild,...
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| Formato: | Online |
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| Idioma: | inglés |
| Publicado: |
MDPI - Multidisciplinary Digital Publishing Institute
2026
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| Acceso en liña: | ONIX_20260416T142754_9783725867721_30 |
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| _version_ | 1869517911732781056 |
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| collection | Directory of Open Access Books |
| description | Membrane technologies play an instrumental role in bioseparation and downstream processing. Membrane operations such as microfiltration, ultrafiltration, and virus filtration are key tools for clarification, concentration, buffer exchange, and viral clearance in biomanufacturing, as they offer mild, selective, and efficient separations for delicate biological products. With advances in biotherapeutics development, membrane technologies have become increasingly pivotal in bioseparation and downstream processing. Compared with conventional packed-bed chromatography, a major advantage of membrane technologies is their convective mass transfer, which enables faster processing times and higher productivity. This advantage is particularly crucial for processing increasingly complex and fragile large biomolecules. In this Special Issue, we have collected a diverse yet cohesive set of eight papers on membrane materials in bioseparation and downstream processing, covering applications ranging from conventional clarification and viral clearance to the purification of emerging modalities, including bispecific antibodies, outer-membrane vesicles, viral vectors, and cells. Collectively, these studies demonstrate that membrane technologies have progressed from an auxiliary role to a central, enabling tool in biomanufacturing. We hope that this Special Issue not only provides a timely update on the applications of membrane materials in bioseparation and downstream processing but also serves as a catalyst for continued innovation in membrane technologies. |
| format | Online |
| id | doab-20.500.12854ir-175375 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1753752026-04-16T20:32:29Z Application of Membrane Materials in Bioseparation and Downstream Processing Zhang, Wei Kong, Lingxue Virus filtration Protein fouling Monoclonal antibody Virus clearance AAV purification AAV ultrafiltration AAV membrane filtration AAV PCTE membrane AAV infectivity AAV live cell imaging AAV ELISA QPCR AAV TEM Aggregation Flux decline Fouling Membrane adsorber PH Prefiltration Reversible aggregate Bioreactor harvesting Clarification Continuous biomanufacturing Hydrocyclone Membrane morphology Microfiltration Vibrio natriegens Compressibility index Resistance in series model Hermia’s laws Ceramic membranes Ultrafiltration CFF Outer membrane vesicles Different sizes Membrane filtration Escherichia coli Nissle 1917 Heterogeneity Macrophage Downstream process Membrane chromatography Quality by design Flow-through mode Protein binding Ion-exchange nanofiber membrane Computational approaches Meso-scale simulations CFD DEM N A thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PN Chemistry Membrane technologies play an instrumental role in bioseparation and downstream processing. Membrane operations such as microfiltration, ultrafiltration, and virus filtration are key tools for clarification, concentration, buffer exchange, and viral clearance in biomanufacturing, as they offer mild, selective, and efficient separations for delicate biological products. With advances in biotherapeutics development, membrane technologies have become increasingly pivotal in bioseparation and downstream processing. Compared with conventional packed-bed chromatography, a major advantage of membrane technologies is their convective mass transfer, which enables faster processing times and higher productivity. This advantage is particularly crucial for processing increasingly complex and fragile large biomolecules. In this Special Issue, we have collected a diverse yet cohesive set of eight papers on membrane materials in bioseparation and downstream processing, covering applications ranging from conventional clarification and viral clearance to the purification of emerging modalities, including bispecific antibodies, outer-membrane vesicles, viral vectors, and cells. Collectively, these studies demonstrate that membrane technologies have progressed from an auxiliary role to a central, enabling tool in biomanufacturing. We hope that this Special Issue not only provides a timely update on the applications of membrane materials in bioseparation and downstream processing but also serves as a catalyst for continued innovation in membrane technologies. 2026-04-16T20:32:23Z 2026-04-16T20:32:23Z 2026 book ONIX_20260416T142754_9783725867721_30 9783725867721 9783725867738 https://directory.doabooks.org/handle/20.500.12854/175375 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/ https://mdpi.com/books/pdfview/book/12290 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-6773-8 10.3390/books978-3-7258-6773-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725867721 9783725867738 142 CH open access |
| spellingShingle | Virus filtration Protein fouling Monoclonal antibody Virus clearance AAV purification AAV ultrafiltration AAV membrane filtration AAV PCTE membrane AAV infectivity AAV live cell imaging AAV ELISA QPCR AAV TEM Aggregation Flux decline Fouling Membrane adsorber PH Prefiltration Reversible aggregate Bioreactor harvesting Clarification Continuous biomanufacturing Hydrocyclone Membrane morphology Microfiltration Vibrio natriegens Compressibility index Resistance in series model Hermia’s laws Ceramic membranes Ultrafiltration CFF Outer membrane vesicles Different sizes Membrane filtration Escherichia coli Nissle 1917 Heterogeneity Macrophage Downstream process Membrane chromatography Quality by design Flow-through mode Protein binding Ion-exchange nanofiber membrane Computational approaches Meso-scale simulations CFD DEM N A thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PN Chemistry Application of Membrane Materials in Bioseparation and Downstream Processing |
| title | Application of Membrane Materials in Bioseparation and Downstream Processing |
| title_full | Application of Membrane Materials in Bioseparation and Downstream Processing |
| title_fullStr | Application of Membrane Materials in Bioseparation and Downstream Processing |
| title_full_unstemmed | Application of Membrane Materials in Bioseparation and Downstream Processing |
| title_short | Application of Membrane Materials in Bioseparation and Downstream Processing |
| title_sort | application of membrane materials in bioseparation and downstream processing |
| topic | Virus filtration Protein fouling Monoclonal antibody Virus clearance AAV purification AAV ultrafiltration AAV membrane filtration AAV PCTE membrane AAV infectivity AAV live cell imaging AAV ELISA QPCR AAV TEM Aggregation Flux decline Fouling Membrane adsorber PH Prefiltration Reversible aggregate Bioreactor harvesting Clarification Continuous biomanufacturing Hydrocyclone Membrane morphology Microfiltration Vibrio natriegens Compressibility index Resistance in series model Hermia’s laws Ceramic membranes Ultrafiltration CFF Outer membrane vesicles Different sizes Membrane filtration Escherichia coli Nissle 1917 Heterogeneity Macrophage Downstream process Membrane chromatography Quality by design Flow-through mode Protein binding Ion-exchange nanofiber membrane Computational approaches Meso-scale simulations CFD DEM N A thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PN Chemistry |
| topic_facet | Virus filtration Protein fouling Monoclonal antibody Virus clearance AAV purification AAV ultrafiltration AAV membrane filtration AAV PCTE membrane AAV infectivity AAV live cell imaging AAV ELISA QPCR AAV TEM Aggregation Flux decline Fouling Membrane adsorber PH Prefiltration Reversible aggregate Bioreactor harvesting Clarification Continuous biomanufacturing Hydrocyclone Membrane morphology Microfiltration Vibrio natriegens Compressibility index Resistance in series model Hermia’s laws Ceramic membranes Ultrafiltration CFF Outer membrane vesicles Different sizes Membrane filtration Escherichia coli Nissle 1917 Heterogeneity Macrophage Downstream process Membrane chromatography Quality by design Flow-through mode Protein binding Ion-exchange nanofiber membrane Computational approaches Meso-scale simulations CFD DEM N A thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PN Chemistry |
| url | ONIX_20260416T142754_9783725867721_30 |