Small-Molecule Modulators Targeting Emerging Therapeutic Pathways
This Reprint presents a focused collection of recent research articles and reviews on small molecule modulators targeting emerging therapeutic pathways. The contributions highlight current advances in medicinal chemistry and chemical biology, integrating molecular design, synthesis, and biological e...
Tallennettuna:
| Aineistotyyppi: | Online |
|---|---|
| Kieli: | englanti |
| Julkaistu: |
MDPI - Multidisciplinary Digital Publishing Institute
2026
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| Aiheet: | |
| Linkit: | ONIX_20260416T142754_9783725866649_49 |
| Tagit: |
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| _version_ | 1869527846401081344 |
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| collection | Directory of Open Access Books |
| description | This Reprint presents a focused collection of recent research articles and reviews on small molecule modulators targeting emerging therapeutic pathways. The contributions highlight current advances in medicinal chemistry and chemical biology, integrating molecular design, synthesis, and biological evaluation to address complex disease mechanisms. Several studies report small molecules that modulate key signaling pathways, overcome therapeutic resistance, and promote regulated cell death, particularly in cancer models. Structural and mechanistic investigations provide molecular-level insights into target engagement, including enzyme and proteasome inhibition, supporting structure-guided drug design. Other contributions combine biophysical methods, computational modeling, and functional assays to clarify mechanisms of action and guide optimization. The Reprint also includes studies on immune and inflammatory modulation, studies on metabolic and lipid signaling regulation, and updated reviews on naturally derived inhibitors and hypoxia-responsive compounds. Together, these works emphasize multidisciplinary approaches and biological relevance in small molecule research. Overall, this Reprint reflects current trends in pathway-oriented therapeutic development and serves as a valuable reference for researchers in drug discovery, chemical biology, and pharmacological sciences. |
| format | Online |
| id | doab-20.500.12854ir-175444 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1754442026-04-16T20:55:57Z Small-Molecule Modulators Targeting Emerging Therapeutic Pathways Zhao, Yujun Immunomodulator Enzymatic modulator PROTAC Molecular glue Modulator of PPI Receptor agonist Receptor antagonist Small molecules thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences This Reprint presents a focused collection of recent research articles and reviews on small molecule modulators targeting emerging therapeutic pathways. The contributions highlight current advances in medicinal chemistry and chemical biology, integrating molecular design, synthesis, and biological evaluation to address complex disease mechanisms. Several studies report small molecules that modulate key signaling pathways, overcome therapeutic resistance, and promote regulated cell death, particularly in cancer models. Structural and mechanistic investigations provide molecular-level insights into target engagement, including enzyme and proteasome inhibition, supporting structure-guided drug design. Other contributions combine biophysical methods, computational modeling, and functional assays to clarify mechanisms of action and guide optimization. The Reprint also includes studies on immune and inflammatory modulation, studies on metabolic and lipid signaling regulation, and updated reviews on naturally derived inhibitors and hypoxia-responsive compounds. Together, these works emphasize multidisciplinary approaches and biological relevance in small molecule research. Overall, this Reprint reflects current trends in pathway-oriented therapeutic development and serves as a valuable reference for researchers in drug discovery, chemical biology, and pharmacological sciences. 2026-04-16T20:55:50Z 2026-04-16T20:55:50Z 2026 book ONIX_20260416T142754_9783725866649_49 9783725866649 9783725866656 https://directory.doabooks.org/handle/20.500.12854/175444 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/ https://mdpi.com/books/pdfview/book/12363 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-6665-6 10.3390/books978-3-7258-6665-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725866649 9783725866656 154 CH open access |
| spellingShingle | Immunomodulator Enzymatic modulator PROTAC Molecular glue Modulator of PPI Receptor agonist Receptor antagonist Small molecules thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Small-Molecule Modulators Targeting Emerging Therapeutic Pathways |
| title | Small-Molecule Modulators Targeting Emerging Therapeutic Pathways |
| title_full | Small-Molecule Modulators Targeting Emerging Therapeutic Pathways |
| title_fullStr | Small-Molecule Modulators Targeting Emerging Therapeutic Pathways |
| title_full_unstemmed | Small-Molecule Modulators Targeting Emerging Therapeutic Pathways |
| title_short | Small-Molecule Modulators Targeting Emerging Therapeutic Pathways |
| title_sort | small molecule modulators targeting emerging therapeutic pathways |
| topic | Immunomodulator Enzymatic modulator PROTAC Molecular glue Modulator of PPI Receptor agonist Receptor antagonist Small molecules thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | Immunomodulator Enzymatic modulator PROTAC Molecular glue Modulator of PPI Receptor agonist Receptor antagonist Small molecules thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20260416T142754_9783725866649_49 |