Metal-Based Nanoparticles’ Biological Activity and Pharmaceutical Applications
Nanoparticles have been the subject of numerous studies owing to their physicochemical characteristics. How metal-based nanoparticles interact with cells, as well as their structures and cellular metabolites, is of particular importance in their applications as drug carriers and in the diagnosis and...
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| Aineistotyyppi: | Online |
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| Kieli: | englanti |
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MDPI - Multidisciplinary Digital Publishing Institute
2026
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| Linkit: | ONIX_20260416T142754_9783725865727_8 |
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| description | Nanoparticles have been the subject of numerous studies owing to their physicochemical characteristics. How metal-based nanoparticles interact with cells, as well as their structures and cellular metabolites, is of particular importance in their applications as drug carriers and in the diagnosis and treatment of various diseases. In this collection of papers, the biological properties of the metal-based nanoparticles are evaluated, including their antibacterial and cytotoxic effects and redox activity. The evaluation of the bacterial activity applies traditional microbiological assays to test the bactericidal effect against some of the most common Gram-positive and Gram-negative bacteria. Cytotoxicity is commonly expressed by viability, which can be estimated from measured cellular endpoints determined in colorimetric standard endpoint assays, but also by the kinetics of the cytotoxic response. The compounds with cytotoxic effects often damage the permeability and structure of the cell membrane and/or cell metabolism. Redox activity is often measured by the effects on oxidative stress. The free radical reactions and generation of reactive oxygen species (ROS) are vital metabolic responses that ensure the body’s homeostasis, functional activity, and adaptation. Any changes in ROS levels or their metabolism are particularly informative; their imbalance is a universal mechanism and cause for the development of diseases. |
| format | Online |
| id | doab-20.500.12854ir-175453 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1754532026-04-16T21:00:42Z Metal-Based Nanoparticles’ Biological Activity and Pharmaceutical Applications Pavlova, Elitsa L. Crans, Debbie C. Polyoxovanadates Pentadecavanadate Mixed valence Toxicology Oral acute toxicity Green synthesis Central composite design Antioxidant activity Antidiabetic activity Process optimization Inorganic nanoparticles Biological synthesis Anticancer activity Antimicrobial activity Clinical trials AgNPs Azadirachta indica Biosynthesize nanoparticles Diabetes Streptozotocin Nanomaterials Doping Toxicity Immune cell Snail Cornu aspersum Copper nanoparticles ZnO NPs Al-doped ZnO NCs Antimicrobial Anticancer activities Ag species Ecotoxicity Luminescence Reactive oxygen species Zeolites Nanoparticles Rare earth metals Lanthanides Rare earth oxides Contrast agents Antitumor effect Antibacterial effect Antioxidant effect Regenerative effect Antigen presentation Breast cancer immunotherapy Gold nanoparticles Immune system activation Tumor cell lysates Silver nanoparticles Cytotoxicity Genotoxicity In vitro In silico Molecular docking Irritable bowel syndrome Mebeverine Zinc oxide nanoparticles Graphitic carbon nitrides Nanocomposite N A thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Nanoparticles have been the subject of numerous studies owing to their physicochemical characteristics. How metal-based nanoparticles interact with cells, as well as their structures and cellular metabolites, is of particular importance in their applications as drug carriers and in the diagnosis and treatment of various diseases. In this collection of papers, the biological properties of the metal-based nanoparticles are evaluated, including their antibacterial and cytotoxic effects and redox activity. The evaluation of the bacterial activity applies traditional microbiological assays to test the bactericidal effect against some of the most common Gram-positive and Gram-negative bacteria. Cytotoxicity is commonly expressed by viability, which can be estimated from measured cellular endpoints determined in colorimetric standard endpoint assays, but also by the kinetics of the cytotoxic response. The compounds with cytotoxic effects often damage the permeability and structure of the cell membrane and/or cell metabolism. Redox activity is often measured by the effects on oxidative stress. The free radical reactions and generation of reactive oxygen species (ROS) are vital metabolic responses that ensure the body’s homeostasis, functional activity, and adaptation. Any changes in ROS levels or their metabolism are particularly informative; their imbalance is a universal mechanism and cause for the development of diseases. 2026-04-16T21:00:34Z 2026-04-16T21:00:34Z 2026 book ONIX_20260416T142754_9783725865727_8 9783725865727 9783725865734 https://directory.doabooks.org/handle/20.500.12854/175453 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/ https://mdpi.com/books/pdfview/book/12372 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-6573-4 10.3390/books978-3-7258-6573-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725865727 9783725865734 304 CH open access |
| spellingShingle | Polyoxovanadates Pentadecavanadate Mixed valence Toxicology Oral acute toxicity Green synthesis Central composite design Antioxidant activity Antidiabetic activity Process optimization Inorganic nanoparticles Biological synthesis Anticancer activity Antimicrobial activity Clinical trials AgNPs Azadirachta indica Biosynthesize nanoparticles Diabetes Streptozotocin Nanomaterials Doping Toxicity Immune cell Snail Cornu aspersum Copper nanoparticles ZnO NPs Al-doped ZnO NCs Antimicrobial Anticancer activities Ag species Ecotoxicity Luminescence Reactive oxygen species Zeolites Nanoparticles Rare earth metals Lanthanides Rare earth oxides Contrast agents Antitumor effect Antibacterial effect Antioxidant effect Regenerative effect Antigen presentation Breast cancer immunotherapy Gold nanoparticles Immune system activation Tumor cell lysates Silver nanoparticles Cytotoxicity Genotoxicity In vitro In silico Molecular docking Irritable bowel syndrome Mebeverine Zinc oxide nanoparticles Graphitic carbon nitrides Nanocomposite N A thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Metal-Based Nanoparticles’ Biological Activity and Pharmaceutical Applications |
| title | Metal-Based Nanoparticles’ Biological Activity and Pharmaceutical Applications |
| title_full | Metal-Based Nanoparticles’ Biological Activity and Pharmaceutical Applications |
| title_fullStr | Metal-Based Nanoparticles’ Biological Activity and Pharmaceutical Applications |
| title_full_unstemmed | Metal-Based Nanoparticles’ Biological Activity and Pharmaceutical Applications |
| title_short | Metal-Based Nanoparticles’ Biological Activity and Pharmaceutical Applications |
| title_sort | metal based nanoparticles rsquo biological activity and pharmaceutical applications |
| topic | Polyoxovanadates Pentadecavanadate Mixed valence Toxicology Oral acute toxicity Green synthesis Central composite design Antioxidant activity Antidiabetic activity Process optimization Inorganic nanoparticles Biological synthesis Anticancer activity Antimicrobial activity Clinical trials AgNPs Azadirachta indica Biosynthesize nanoparticles Diabetes Streptozotocin Nanomaterials Doping Toxicity Immune cell Snail Cornu aspersum Copper nanoparticles ZnO NPs Al-doped ZnO NCs Antimicrobial Anticancer activities Ag species Ecotoxicity Luminescence Reactive oxygen species Zeolites Nanoparticles Rare earth metals Lanthanides Rare earth oxides Contrast agents Antitumor effect Antibacterial effect Antioxidant effect Regenerative effect Antigen presentation Breast cancer immunotherapy Gold nanoparticles Immune system activation Tumor cell lysates Silver nanoparticles Cytotoxicity Genotoxicity In vitro In silico Molecular docking Irritable bowel syndrome Mebeverine Zinc oxide nanoparticles Graphitic carbon nitrides Nanocomposite N A thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | Polyoxovanadates Pentadecavanadate Mixed valence Toxicology Oral acute toxicity Green synthesis Central composite design Antioxidant activity Antidiabetic activity Process optimization Inorganic nanoparticles Biological synthesis Anticancer activity Antimicrobial activity Clinical trials AgNPs Azadirachta indica Biosynthesize nanoparticles Diabetes Streptozotocin Nanomaterials Doping Toxicity Immune cell Snail Cornu aspersum Copper nanoparticles ZnO NPs Al-doped ZnO NCs Antimicrobial Anticancer activities Ag species Ecotoxicity Luminescence Reactive oxygen species Zeolites Nanoparticles Rare earth metals Lanthanides Rare earth oxides Contrast agents Antitumor effect Antibacterial effect Antioxidant effect Regenerative effect Antigen presentation Breast cancer immunotherapy Gold nanoparticles Immune system activation Tumor cell lysates Silver nanoparticles Cytotoxicity Genotoxicity In vitro In silico Molecular docking Irritable bowel syndrome Mebeverine Zinc oxide nanoparticles Graphitic carbon nitrides Nanocomposite N A thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20260416T142754_9783725865727_8 |