Dysbiosis of the Evolved Intestinal Microbiome
While it is clearly recognised that many non-communicable disorders are related to a disturbed microbiome (commonly called dysbiosis, a shortened term for microbiome failure: dysmicrobiosis), there is an absence of widely accepted underlying theories. The aim of this book is to show that all such di...
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| Format: | Online |
| Language: | English |
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MDPI - Multidisciplinary Digital Publishing Institute
2025
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| Online Access: | ONIX_20251218T154939_9783725815241_3 |
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| _version_ | 1869528926559141888 |
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| author | Smith, David |
| author_browse | Smith, David |
| author_facet | Smith, David |
| author_sort | Smith, David |
| collection | Directory of Open Access Books |
| description | While it is clearly recognised that many non-communicable disorders are related to a disturbed microbiome (commonly called dysbiosis, a shortened term for microbiome failure: dysmicrobiosis), there is an absence of widely accepted underlying theories. The aim of this book is to show that all such disorders, be they weight gain, immune system disturbance, or poor mental health, stem from a single underlying problem: the failure to transfer key intestinal microbes from the mother to the new-born during birth. Furthermore, in contrast to the normal, exclusively bacterial approach, the book describes what might be called a “second generation” approach to the microbiome, that emphasises beneficial microeukaryotes acting to coordinate diverse bacterial functionality. Most importantly, lessons have been drawn to guide future research, the aim being to reintroduce these key microbes at the time of birth, alongside breast milk (bank milk if necessary) and before the immune system of the infant is fully established. If all goes as expected, not only can the present “triple plagues” of non-communicable disease be ameliorated more efficiently, but it should also be possible to banish such disease from future populations. Unfortunately, however, beneficial microeukaryotes will be hard to detect, while resistance-inducing oral antibiotics must be limited. |
| format | Online |
| id | doab-20.500.12854ir-176049 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1760492026-04-24T11:17:55Z Dysbiosis of the Evolved Intestinal Microbiome Smith, David Smith, David antibiotic resistance beneficial microeukaryotes dual inheritance hypothesis fecal energy excretion heavy metal toxicity holobiont mathematics of obesity microbiome-gut dissociation mobile genetic elements placebo effect thema EDItEUR::P Mathematics and Science::PS Biology, life sciences While it is clearly recognised that many non-communicable disorders are related to a disturbed microbiome (commonly called dysbiosis, a shortened term for microbiome failure: dysmicrobiosis), there is an absence of widely accepted underlying theories. The aim of this book is to show that all such disorders, be they weight gain, immune system disturbance, or poor mental health, stem from a single underlying problem: the failure to transfer key intestinal microbes from the mother to the new-born during birth. Furthermore, in contrast to the normal, exclusively bacterial approach, the book describes what might be called a “second generation” approach to the microbiome, that emphasises beneficial microeukaryotes acting to coordinate diverse bacterial functionality. Most importantly, lessons have been drawn to guide future research, the aim being to reintroduce these key microbes at the time of birth, alongside breast milk (bank milk if necessary) and before the immune system of the infant is fully established. If all goes as expected, not only can the present “triple plagues” of non-communicable disease be ameliorated more efficiently, but it should also be possible to banish such disease from future populations. Unfortunately, however, beneficial microeukaryotes will be hard to detect, while resistance-inducing oral antibiotics must be limited. 2025-12-20T05:03:43Z 2025-12-20T05:03:43Z 2025-12-18T14:51:23Z 2025 book ONIX_20251218T154939_9783725815241_3 https://library.oapen.org/handle/20.500.12657/109459 9783725815241 https://directory.doabooks.org/handle/20.500.12854/170330 eng open access application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-1523-4 10.3390/books978-3-7258-1523-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725815241 152 Basel, Switzerland open access |
| spellingShingle | antibiotic resistance beneficial microeukaryotes dual inheritance hypothesis fecal energy excretion heavy metal toxicity holobiont mathematics of obesity microbiome-gut dissociation mobile genetic elements placebo effect thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Smith, David Dysbiosis of the Evolved Intestinal Microbiome |
| title | Dysbiosis of the Evolved Intestinal Microbiome |
| title_full | Dysbiosis of the Evolved Intestinal Microbiome |
| title_fullStr | Dysbiosis of the Evolved Intestinal Microbiome |
| title_full_unstemmed | Dysbiosis of the Evolved Intestinal Microbiome |
| title_short | Dysbiosis of the Evolved Intestinal Microbiome |
| title_sort | dysbiosis of the evolved intestinal microbiome |
| topic | antibiotic resistance beneficial microeukaryotes dual inheritance hypothesis fecal energy excretion heavy metal toxicity holobiont mathematics of obesity microbiome-gut dissociation mobile genetic elements placebo effect thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | antibiotic resistance beneficial microeukaryotes dual inheritance hypothesis fecal energy excretion heavy metal toxicity holobiont mathematics of obesity microbiome-gut dissociation mobile genetic elements placebo effect thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20251218T154939_9783725815241_3 |
| work_keys_str_mv | AT smithdavid dysbiosisoftheevolvedintestinalmicrobiome |