Chapter 5 Computational Analysis and Integration of MeDIP-seq Methylome Data
The combinatorial number of possible methylomes in biological time and space is astronomical. Consequently, the computational analysis of methylomes needs to cater for a variety of data, throughput and resolution. Here, we review recent advances in 2nd generation sequencing (2GS) with a focus on the...
I tiakina i:
| Ngā kaituhi matua: | , |
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| Hōputu: | Online |
| Reo: | Ingarihi |
| I whakaputaina: |
InTechOpen
2021
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| Ngā marau: | |
| Urunga tuihono: | 627316 |
| Ngā Tūtohu: |
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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| _version_ | 1869524881357406208 |
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| author | Wilson, Gareth A. Beck, Stephan |
| author_browse | Beck, Stephan Wilson, Gareth A. |
| author_facet | Wilson, Gareth A. Beck, Stephan |
| author_sort | Wilson, Gareth A. |
| collection | Directory of Open Access Books |
| description | The combinatorial number of possible methylomes in biological time and space is astronomical. Consequently, the computational analysis of methylomes needs to cater for a variety of data, throughput and resolution. Here, we review recent advances in 2nd generation sequencing (2GS) with a focus on the different methods used for the analysis of MeDIP-seq data. The challenges and opportunities presented by the integration of methylation data with other genomic data types are discussed as is the potential impact of emerging 3rd generation sequencing (3GS) based technologies on methylation analysis. |
| format | Online |
| id | doab-20.500.12854ir-26001 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | InTechOpen |
| publisherStr | InTechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-260012025-07-30T09:00:23Z Chapter 5 Computational Analysis and Integration of MeDIP-seq Methylome Data Wilson, Gareth A. Beck, Stephan sequencing biochemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry The combinatorial number of possible methylomes in biological time and space is astronomical. Consequently, the computational analysis of methylomes needs to cater for a variety of data, throughput and resolution. Here, we review recent advances in 2nd generation sequencing (2GS) with a focus on the different methods used for the analysis of MeDIP-seq data. The challenges and opportunities presented by the integration of methylation data with other genomic data types are discussed as is the potential impact of emerging 3rd generation sequencing (3GS) based technologies on methylation analysis. 2021-02-10T12:58:18Z 2019-10-04 14:42:20 2020-04-01T13:39:01Z 2017-04-12 23:55 2019-10-04 14:42:20 2020-04-01T13:39:01Z 2017-03-01 23:55:55 2019-10-04 14:42:20 2020-04-01T13:39:01Z 2016 chapter 627316 OCN: 1030819225 http://library.oapen.org/handle/20.500.12657/31543 https://directory.doabooks.org/handle/20.500.12854/26001 eng open access image/jpeg image/jpeg image/jpeg image/jpeg n/a n/a n/a n/a https://library.oapen.org/bitstream/20.500.12657/31543/1/627316.pdf https://library.oapen.org/bitstream/20.500.12657/31543/1/627316.pdf https://library.oapen.org/bitstream/20.500.12657/31543/1/627316.pdf https://library.oapen.org/bitstream/20.500.12657/31543/1/627316.pdf InTechOpen 10.5772/61207 10.5772/61207 035ecc65-6737-43cf-a13a-6bdf67ce01f4 Next Generation Sequencing - Advances, Applications and Challenges Wellcome Trust d859fbd3-d884-4090-a0ec-baf821c9abfd Wellcome 99148 open access |
| spellingShingle | sequencing biochemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry Wilson, Gareth A. Beck, Stephan Chapter 5 Computational Analysis and Integration of MeDIP-seq Methylome Data |
| title | Chapter 5 Computational Analysis and Integration of MeDIP-seq Methylome Data |
| title_full | Chapter 5 Computational Analysis and Integration of MeDIP-seq Methylome Data |
| title_fullStr | Chapter 5 Computational Analysis and Integration of MeDIP-seq Methylome Data |
| title_full_unstemmed | Chapter 5 Computational Analysis and Integration of MeDIP-seq Methylome Data |
| title_short | Chapter 5 Computational Analysis and Integration of MeDIP-seq Methylome Data |
| title_sort | chapter 5 computational analysis and integration of medip seq methylome data |
| topic | sequencing biochemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| topic_facet | sequencing biochemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| url | 627316 |
| work_keys_str_mv | AT wilsongaretha chapter5computationalanalysisandintegrationofmedipseqmethylomedata AT beckstephan chapter5computationalanalysisandintegrationofmedipseqmethylomedata |