Chapter 7 Aptamer-Nanoparticle Bioconjugates for Drug Delivery
Drug delivery systems traditionally relied on passive diffusion mechanisms for targeting and releasing of therapeutically active molecules. The major problems associated with traditional delivery are poor specificity and dose-limited toxicity. Nanoparticles have found applicability in the deve...
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| Format: | Online |
| Langue: | anglais |
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InTechOpen
2021
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| Accès en ligne: | 612587 |
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| author | Schäfer, Thomas Özalp, Veli C. Özalp, Veli C. Schäfer, Thomas |
| author_browse | Schäfer, Thomas Özalp, Veli C. |
| author_facet | Schäfer, Thomas Özalp, Veli C. Özalp, Veli C. Schäfer, Thomas |
| author_sort | Schäfer, Thomas |
| collection | Directory of Open Access Books |
| description | Drug delivery systems traditionally relied on passive diffusion mechanisms for targeting and releasing of therapeutically active molecules. The major problems associated with
traditional delivery are poor specificity and dose-limited toxicity. Nanoparticles have found
applicability in the development of novel drug delivery systems by easily overcoming
toxicity problem. However, specificity of delivery has remained as a challenge.
Developments in the methods of reaching to targeted tissue have lead to new and improved
drug delivery platforms. Recently, active targeting has been incorporated by cell specific
ligands such as antibodies, lectins, growth factor receptors. More recently, aptamers gained
popularity in construction of novel actively targeted drug delivery systems (Ozalp et al.,
2011). Considerable proportions of aptamer-based delivery systems have been incorporated
to a variety of nanomaterials in order to improve their specific targeting properties (Chen et
al., 2011; Zhou et al., 2011). |
| format | Online |
| id | doab-20.500.12854ir-29503 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | InTechOpen |
| publisherStr | InTechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-295032025-05-08T07:08:45Z Chapter 7 Aptamer-Nanoparticle Bioconjugates for Drug Delivery Schäfer, Thomas Özalp, Veli C. Özalp, Veli C. Schäfer, Thomas drug delivery nanoparticles drug delivery nanoparticles Aptamer Protein Drug delivery systems traditionally relied on passive diffusion mechanisms for targeting and releasing of therapeutically active molecules. The major problems associated with traditional delivery are poor specificity and dose-limited toxicity. Nanoparticles have found applicability in the development of novel drug delivery systems by easily overcoming toxicity problem. However, specificity of delivery has remained as a challenge. Developments in the methods of reaching to targeted tissue have lead to new and improved drug delivery platforms. Recently, active targeting has been incorporated by cell specific ligands such as antibodies, lectins, growth factor receptors. More recently, aptamers gained popularity in construction of novel actively targeted drug delivery systems (Ozalp et al., 2011). Considerable proportions of aptamer-based delivery systems have been incorporated to a variety of nanomaterials in order to improve their specific targeting properties (Chen et al., 2011; Zhou et al., 2011). 2021-02-10T12:58:18Z 2019-10-04 14:28:10 2020-04-01T14:07:00Z 2016-08-01 23:55 2019-10-04 14:28:10 2020-04-01T14:07:00Z 2016-12-31 23:55:55 2019-10-04 14:28:10 2020-04-01T14:07:00Z 2012 chapter 612587 OCN: 1030822012 http://library.oapen.org/handle/20.500.12657/32346 https://directory.doabooks.org/handle/20.500.12854/29503 eng open access image/jpeg image/jpeg image/jpeg image/jpeg image/jpeg n/a n/a n/a n/a n/a https://library.oapen.org/bitstream/20.500.12657/32346/1/612587.pdf https://library.oapen.org/bitstream/20.500.12657/32346/1/612587.pdf https://library.oapen.org/bitstream/20.500.12657/32346/1/612587.pdf https://library.oapen.org/bitstream/20.500.12657/32346/1/612587.pdf https://library.oapen.org/bitstream/20.500.12657/32346/1/612587.pdf InTechOpen 10.5772/35188 10.5772/35188 035ecc65-6737-43cf-a13a-6bdf67ce01f4 The Delivery of Nanoparticles FP7 Ideas: European Research Council 7292b17b-f01a-4016-94d3-d7fb5ef9fb79 European Research Council (ERC) EU collection 209842 FP7 open access |
| spellingShingle | drug delivery nanoparticles drug delivery nanoparticles Aptamer Protein Schäfer, Thomas Özalp, Veli C. Özalp, Veli C. Schäfer, Thomas Chapter 7 Aptamer-Nanoparticle Bioconjugates for Drug Delivery |
| title | Chapter 7 Aptamer-Nanoparticle Bioconjugates for Drug Delivery |
| title_full | Chapter 7 Aptamer-Nanoparticle Bioconjugates for Drug Delivery |
| title_fullStr | Chapter 7 Aptamer-Nanoparticle Bioconjugates for Drug Delivery |
| title_full_unstemmed | Chapter 7 Aptamer-Nanoparticle Bioconjugates for Drug Delivery |
| title_short | Chapter 7 Aptamer-Nanoparticle Bioconjugates for Drug Delivery |
| title_sort | chapter 7 aptamer nanoparticle bioconjugates for drug delivery |
| topic | drug delivery nanoparticles drug delivery nanoparticles Aptamer Protein |
| topic_facet | drug delivery nanoparticles drug delivery nanoparticles Aptamer Protein |
| url | 612587 |
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