Chapter 8 Computational Modelling of the Steps Involved in Photodynamic Therapy
Photodynamic therapy (PDT) is a branch of phototherapy that has seen a surge of interest in the last few decades, due to its potential in the treatment of various cancers, infections and heart disease.(Bonnett, 2000) This chapter aims to give an overview of the various photochemical steps invo...
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| Główni autorzy: | , |
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| Format: | Online |
| Język: | angielski |
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InTechOpen
2021
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| Hasła przedmiotowe: | |
| Dostęp online: | 612605 |
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| _version_ | 1869515404787843072 |
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| author | Paterson, Martin J. Bergendahl, L. Therese |
| author_browse | Bergendahl, L. Therese Paterson, Martin J. |
| author_facet | Paterson, Martin J. Bergendahl, L. Therese |
| author_sort | Paterson, Martin J. |
| collection | Directory of Open Access Books |
| description | Photodynamic therapy (PDT) is a branch of phototherapy that has seen a surge of interest in the last few decades, due to its potential in the treatment of various cancers, infections and
heart disease.(Bonnett, 2000) This chapter aims to give an overview of the various
photochemical steps involved in PDT as a cancer therapy, and in particular the challenges
and insight gained from their theoretical description. After a brief review of PDT in general,
in a biological and chemical context, the photochemical steps involved will be discussed,
detailing the computational techniques required to model these chemical pathways
theoretically. We will detail the methodologies that can currently be applied, as well as their
limitations of use at present, and areas requiring further development. |
| format | Online |
| id | doab-20.500.12854ir-32242 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | InTechOpen |
| publisherStr | InTechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-322422025-05-08T09:54:35Z Chapter 8 Computational Modelling of the Steps Involved in Photodynamic Therapy Paterson, Martin J. Bergendahl, L. Therese computational modelling photodynamic therapy computational modelling photodynamic therapy Electron Excited state Ground state Molecule Multi-configurational self-consistent field Pacific Time Zone Photosensitizer Porphyrin Wave function Photodynamic therapy (PDT) is a branch of phototherapy that has seen a surge of interest in the last few decades, due to its potential in the treatment of various cancers, infections and heart disease.(Bonnett, 2000) This chapter aims to give an overview of the various photochemical steps involved in PDT as a cancer therapy, and in particular the challenges and insight gained from their theoretical description. After a brief review of PDT in general, in a biological and chemical context, the photochemical steps involved will be discussed, detailing the computational techniques required to model these chemical pathways theoretically. We will detail the methodologies that can currently be applied, as well as their limitations of use at present, and areas requiring further development. 2021-02-10T12:58:18Z 2019-10-04 14:33:32 2020-04-01T14:06:53Z 2016-08-01 23:55 2019-10-04 14:33:32 2020-04-01T14:06:53Z 2016-12-31 23:55:55 2019-10-04 14:33:32 2020-04-01T14:06:53Z 2012 chapter 612605 OCN: 1030819927 http://library.oapen.org/handle/20.500.12657/32338 https://directory.doabooks.org/handle/20.500.12854/32242 eng open access image/jpeg image/jpeg image/jpeg image/jpeg image/jpeg n/a n/a n/a n/a n/a https://library.oapen.org/bitstream/20.500.12657/32338/1/612605.pdf https://library.oapen.org/bitstream/20.500.12657/32338/1/612605.pdf https://library.oapen.org/bitstream/20.500.12657/32338/1/612605.pdf https://library.oapen.org/bitstream/20.500.12657/32338/1/612605.pdf https://library.oapen.org/bitstream/20.500.12657/32338/1/612605.pdf InTechOpen 10.5772/37654 10.5772/37654 035ecc65-6737-43cf-a13a-6bdf67ce01f4 Molecular Photochemistry - Various Aspects FP7 Ideas: European Research Council 7292b17b-f01a-4016-94d3-d7fb5ef9fb79 European Research Council (ERC) EU collection 258990 FP7 open access |
| spellingShingle | computational modelling photodynamic therapy computational modelling photodynamic therapy Electron Excited state Ground state Molecule Multi-configurational self-consistent field Pacific Time Zone Photosensitizer Porphyrin Wave function Paterson, Martin J. Bergendahl, L. Therese Chapter 8 Computational Modelling of the Steps Involved in Photodynamic Therapy |
| title | Chapter 8 Computational Modelling of the Steps Involved in Photodynamic Therapy |
| title_full | Chapter 8 Computational Modelling of the Steps Involved in Photodynamic Therapy |
| title_fullStr | Chapter 8 Computational Modelling of the Steps Involved in Photodynamic Therapy |
| title_full_unstemmed | Chapter 8 Computational Modelling of the Steps Involved in Photodynamic Therapy |
| title_short | Chapter 8 Computational Modelling of the Steps Involved in Photodynamic Therapy |
| title_sort | chapter 8 computational modelling of the steps involved in photodynamic therapy |
| topic | computational modelling photodynamic therapy computational modelling photodynamic therapy Electron Excited state Ground state Molecule Multi-configurational self-consistent field Pacific Time Zone Photosensitizer Porphyrin Wave function |
| topic_facet | computational modelling photodynamic therapy computational modelling photodynamic therapy Electron Excited state Ground state Molecule Multi-configurational self-consistent field Pacific Time Zone Photosensitizer Porphyrin Wave function |
| url | 612605 |
| work_keys_str_mv | AT patersonmartinj chapter8computationalmodellingofthestepsinvolvedinphotodynamictherapy AT bergendahlltherese chapter8computationalmodellingofthestepsinvolvedinphotodynamictherapy |