Chapter 3 Vitamin C Alimentation via SLC Solute Carriers
Although mortality rates from pneumonia and sepsis are decreasing in many parts of the world, the incidence of these conditions continues to rise, likely due to an increasingly ageing population. Case reports and observational studies indicate a strong association between vitamin C status and infect...
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| Formatua: | Online |
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Taylor & Francis
2021
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| Sarrera elektronikoa: | https://library.oapen.org/handle/20.500.12657/40106 |
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| author | Nydegger, Damien Gyimesi, Gergely Hediger, Matthias |
| author_browse | Gyimesi, Gergely Hediger, Matthias Nydegger, Damien |
| author_facet | Nydegger, Damien Gyimesi, Gergely Hediger, Matthias |
| author_sort | Nydegger, Damien |
| collection | Directory of Open Access Books |
| description | Although mortality rates from pneumonia and sepsis are decreasing in many parts of the world, the incidence of these conditions continues to rise, likely due to an increasingly ageing population. Case reports and observational studies indicate a strong association between vitamin C status and infectious conditions, with vitamin C deficiency predisposing individuals to infections, and conversely, infections precipitating a diminished vitamin C status. The requirements for vitamin C increase with the severity of the infectious condition, with gram amounts required to normalize the vitamin C status of critically ill patients. Over the past few years, there has been renewed interest in the role that vitamin C may play in severe infectious conditions. Vitamin C has a plethora of physiological effects, primarily due to its activity as a cofactor for a growing group of biosynthetic and regulatory enzymes, with the potential to regulate thousands of genes and cell signaling pathways. Small intervention studies have indicated that administration of gram doses of vitamin C to patients with pneumonia and sepsis improves organ function and potentially decreases mortality, although this remains to be confirmed in larger trials. The long-term quality of life outcomes of these patients also remains to be determined. |
| format | Online |
| id | doab-20.500.12854ir-33463 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Taylor & Francis |
| publisherStr | Taylor & Francis |
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| spelling | doab-20.500.12854ir-334632025-03-12T20:06:16Z Chapter 3 Vitamin C Alimentation via SLC Solute Carriers Nydegger, Damien Gyimesi, Gergely Hediger, Matthias antioxidants ascorbic acid infectious disease intravenous ascorbate thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Although mortality rates from pneumonia and sepsis are decreasing in many parts of the world, the incidence of these conditions continues to rise, likely due to an increasingly ageing population. Case reports and observational studies indicate a strong association between vitamin C status and infectious conditions, with vitamin C deficiency predisposing individuals to infections, and conversely, infections precipitating a diminished vitamin C status. The requirements for vitamin C increase with the severity of the infectious condition, with gram amounts required to normalize the vitamin C status of critically ill patients. Over the past few years, there has been renewed interest in the role that vitamin C may play in severe infectious conditions. Vitamin C has a plethora of physiological effects, primarily due to its activity as a cofactor for a growing group of biosynthetic and regulatory enzymes, with the potential to regulate thousands of genes and cell signaling pathways. Small intervention studies have indicated that administration of gram doses of vitamin C to patients with pneumonia and sepsis improves organ function and potentially decreases mortality, although this remains to be confirmed in larger trials. The long-term quality of life outcomes of these patients also remains to be determined. 2021-02-10T14:08:15Z 2021-02-10T14:08:15Z 2020-07-27T09:50:33Z 2020 chapter https://library.oapen.org/handle/20.500.12657/40106 9780429442025 https://directory.doabooks.org/handle/20.500.12854/33463 eng open access image/jpeg image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International Attribution-NonCommercial-NoDerivatives 4.0 International https://library.oapen.org/bitstream/20.500.12657/40106/1/9781138337992_oachapter3.pdf https://library.oapen.org/bitstream/20.500.12657/40106/1/9781138337992_oachapter3.pdf Taylor & Francis CRC Press fa69b019-f4ee-4979-8d42-c6b6c476b5f0 Vitamin C 9780429442025 CRC Press 18 open access |
| spellingShingle | antioxidants ascorbic acid infectious disease intravenous ascorbate thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Nydegger, Damien Gyimesi, Gergely Hediger, Matthias Chapter 3 Vitamin C Alimentation via SLC Solute Carriers |
| title | Chapter 3 Vitamin C Alimentation via SLC Solute Carriers |
| title_full | Chapter 3 Vitamin C Alimentation via SLC Solute Carriers |
| title_fullStr | Chapter 3 Vitamin C Alimentation via SLC Solute Carriers |
| title_full_unstemmed | Chapter 3 Vitamin C Alimentation via SLC Solute Carriers |
| title_short | Chapter 3 Vitamin C Alimentation via SLC Solute Carriers |
| title_sort | chapter 3 vitamin c alimentation via slc solute carriers |
| topic | antioxidants ascorbic acid infectious disease intravenous ascorbate thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | antioxidants ascorbic acid infectious disease intravenous ascorbate thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | https://library.oapen.org/handle/20.500.12657/40106 |
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