Human Challenge Studies in Endemic Settings
This open access book provides an extensive review of ethical and regulatory issues related to human infection challenge studies, with a particular focus on the expansion of this type of research into endemic settings and/or low- and middle-income countries (LMICs). Human challenge studies (HCS) inv...
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| Fformat: | Online |
| Iaith: | Saesneg |
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Springer Nature
2021
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| Pynciau: | |
| Mynediad Ar-lein: | ONIX_20200921_9783030414801_89 |
| Tagiau: |
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
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| _version_ | 1869525525377056768 |
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| author | Jamrozik, Euzebiusz Selgelid, Michael J. |
| author_browse | Jamrozik, Euzebiusz Selgelid, Michael J. |
| author_facet | Jamrozik, Euzebiusz Selgelid, Michael J. |
| author_sort | Jamrozik, Euzebiusz |
| collection | Directory of Open Access Books |
| description | This open access book provides an extensive review of ethical and regulatory issues related to human infection challenge studies, with a particular focus on the expansion of this type of research into endemic settings and/or low- and middle-income countries (LMICs). Human challenge studies (HCS) involve the intentional infection of research participants, and this type of research is rapidly increasing in frequency worldwide. HCS are widely considered to be an especially promising approach to vaccine development, including for pathogens endemic to LMICs. However, challenge studies are sometimes controversial and raise complex ethical issues, some of which are especially salient in endemic and/or LMIC settings. Informed by qualitative interviews with experts in infectious diseases and bioethics, this book highlights areas of ethical consensus and controversy concerning this kind of research. As the first volume to focus on ethical issues associated with human challenge studies, it sets the agenda for further work in this important area of global health research; contributes to current debates in research ethics; and aims to inform regulatory policy and research practice. Insofar as it focuses on HCS in (endemic) settings where diseases are present and/or widespread, much of the analysis provided here is directly relevant to HCS involving pandemic diseases including COVID19. |
| format | Online |
| id | doab-20.500.12854ir-35896 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Springer Nature |
| publisherStr | Springer Nature |
| record_format | ojs |
| spelling | doab-20.500.12854ir-358962025-03-16T15:09:45Z Human Challenge Studies in Endemic Settings Jamrozik, Euzebiusz Selgelid, Michael J. Bioethics Infectious Diseases Vaccine Development and Health Moral Philosophy and Applied Ethics Internal Medicine Pharmacology Development Studies human challenge studies Open Access capacity building in low-income countries capacity building in middle-income countries malariotherapy intentional infection ethics of challenge studies challenge studies in endemic settings challenge studies and vulnerable populations Falciparum malaria challenge studies in Africa Infectious & contagious diseases Immunology Development studies thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAD Bioethics thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTP Development studies This open access book provides an extensive review of ethical and regulatory issues related to human infection challenge studies, with a particular focus on the expansion of this type of research into endemic settings and/or low- and middle-income countries (LMICs). Human challenge studies (HCS) involve the intentional infection of research participants, and this type of research is rapidly increasing in frequency worldwide. HCS are widely considered to be an especially promising approach to vaccine development, including for pathogens endemic to LMICs. However, challenge studies are sometimes controversial and raise complex ethical issues, some of which are especially salient in endemic and/or LMIC settings. Informed by qualitative interviews with experts in infectious diseases and bioethics, this book highlights areas of ethical consensus and controversy concerning this kind of research. As the first volume to focus on ethical issues associated with human challenge studies, it sets the agenda for further work in this important area of global health research; contributes to current debates in research ethics; and aims to inform regulatory policy and research practice. Insofar as it focuses on HCS in (endemic) settings where diseases are present and/or widespread, much of the analysis provided here is directly relevant to HCS involving pandemic diseases including COVID19. 2021-02-10T14:30:41Z 2021-02-10T14:30:41Z 2020-09-21T13:41:09Z 2021 book ONIX_20200921_9783030414801_89 OCN: 1192491583 https://library.oapen.org/handle/20.500.12657/41732 https://directory.doabooks.org/handle/20.500.12854/35896 eng SpringerBriefs in Ethics open access image/jpeg image/jpeg image/jpeg n/a n/a n/a https://library.oapen.org/bitstream/20.500.12657/41732/1/2021_Book_HumanChallengeStudiesInEndemic.pdf https://library.oapen.org/bitstream/20.500.12657/41732/1/2021_Book_HumanChallengeStudiesInEndemic.pdf https://library.oapen.org/bitstream/20.500.12657/41732/1/2021_Book_HumanChallengeStudiesInEndemic.pdf Springer Nature Springer 10.1007/978-3-030-41480-1 10.1007/978-3-030-41480-1 9fa3421d-f917-4153-b9ab-fc337c396b5a Springer 134 open access |
| spellingShingle | Bioethics Infectious Diseases Vaccine Development and Health Moral Philosophy and Applied Ethics Internal Medicine Pharmacology Development Studies human challenge studies Open Access capacity building in low-income countries capacity building in middle-income countries malariotherapy intentional infection ethics of challenge studies challenge studies in endemic settings challenge studies and vulnerable populations Falciparum malaria challenge studies in Africa Infectious & contagious diseases Immunology Development studies thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAD Bioethics thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTP Development studies Jamrozik, Euzebiusz Selgelid, Michael J. Human Challenge Studies in Endemic Settings |
| title | Human Challenge Studies in Endemic Settings |
| title_full | Human Challenge Studies in Endemic Settings |
| title_fullStr | Human Challenge Studies in Endemic Settings |
| title_full_unstemmed | Human Challenge Studies in Endemic Settings |
| title_short | Human Challenge Studies in Endemic Settings |
| title_sort | human challenge studies in endemic settings |
| topic | Bioethics Infectious Diseases Vaccine Development and Health Moral Philosophy and Applied Ethics Internal Medicine Pharmacology Development Studies human challenge studies Open Access capacity building in low-income countries capacity building in middle-income countries malariotherapy intentional infection ethics of challenge studies challenge studies in endemic settings challenge studies and vulnerable populations Falciparum malaria challenge studies in Africa Infectious & contagious diseases Immunology Development studies thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAD Bioethics thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTP Development studies |
| topic_facet | Bioethics Infectious Diseases Vaccine Development and Health Moral Philosophy and Applied Ethics Internal Medicine Pharmacology Development Studies human challenge studies Open Access capacity building in low-income countries capacity building in middle-income countries malariotherapy intentional infection ethics of challenge studies challenge studies in endemic settings challenge studies and vulnerable populations Falciparum malaria challenge studies in Africa Infectious & contagious diseases Immunology Development studies thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAD Bioethics thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTP Development studies |
| url | ONIX_20200921_9783030414801_89 |
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