30 years old: O-GlcNAc Reaches Age of Reason - Regulation of Cell Signaling and Metabolism by O-GlcNAcylation
Hundreds post-translational modifications (PTM) were characterized among which a large variety of glycosylations including O-GlcNAcylation. Since its discovery, O-GlcNAcylation has emerged as an unavoidable PTM widespread in the living beings including animal and plant cells, protists, bacteria and...
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| المؤلفون الرئيسيون: | , |
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| التنسيق: | Online |
| اللغة: | الإنجليزية |
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Frontiers Media SA
2021
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| الوصول للمادة أونلاين: | 18701 |
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| _version_ | 1869524399488499712 |
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| author | Tarik Issad Tony Lefebvre |
| author_browse | Tarik Issad Tony Lefebvre |
| author_facet | Tarik Issad Tony Lefebvre |
| author_sort | Tarik Issad |
| collection | Directory of Open Access Books |
| description | Hundreds post-translational modifications (PTM) were characterized among which a large variety of glycosylations including O-GlcNAcylation. Since its discovery, O-GlcNAcylation has emerged as an unavoidable PTM widespread in the living beings including animal and plant cells, protists, bacteria and viruses. In opposition to N- and O-glycosylations, O-GlcNAcylation only consists in the transfer of a single N-acetylglucosamine moiety through a beta-linkage onto serine and threonine residues of proteins confined within the cytosol, the nucleus and the mitochondria. The O-GlcNAc group is provided by UDP-GlcNAc, the end-product of the hexosamine biosynthetic pathway located at the crossroad of cell metabolisms making O-GlcNAcylation a PTM which level tightly reflects nutritional status; therefore regulation of cell homeostasis should be intimately correlated to lifestyle and environment. Like phosphorylation, with which it can compete, O-GlcNAcylation is reversible. This versatility is managed by OGT (O-GlcNAc transferase) that transfers the GlcNAc group and OGA (O-GlcNAcase) that removes it. Also, like its unsweetened counterpart, O-GlcNAcylation controls fundamental processes, e.g. protein fate, chromatin topology, DNA demethylation and, as recently revealed, circadian clock. Deregulation of O-GlcNAc dynamism may be involved in the emergence of cancers, neuronal and metabolic disorders such as Alzheimer's or diabetes respectively. This Research Topic in Frontiers in Endocrinology is the opportunity to celebrate the thirtieth anniversary of the discovery of "O-GlcNAc" by Gerald W. Hart. |
| format | Online |
| id | doab-20.500.12854ir-39892 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-398922022-01-31T19:57:22Z 30 years old: O-GlcNAc Reaches Age of Reason - Regulation of Cell Signaling and Metabolism by O-GlcNAcylation Tarik Issad Tony Lefebvre RC648-665 R5-920 nutrition Hexosamine biosynthetic pathway O GlcNAcylation OGA Inflammation Metabolism OGT Cell signaling epigenetics Cancer Hundreds post-translational modifications (PTM) were characterized among which a large variety of glycosylations including O-GlcNAcylation. Since its discovery, O-GlcNAcylation has emerged as an unavoidable PTM widespread in the living beings including animal and plant cells, protists, bacteria and viruses. In opposition to N- and O-glycosylations, O-GlcNAcylation only consists in the transfer of a single N-acetylglucosamine moiety through a beta-linkage onto serine and threonine residues of proteins confined within the cytosol, the nucleus and the mitochondria. The O-GlcNAc group is provided by UDP-GlcNAc, the end-product of the hexosamine biosynthetic pathway located at the crossroad of cell metabolisms making O-GlcNAcylation a PTM which level tightly reflects nutritional status; therefore regulation of cell homeostasis should be intimately correlated to lifestyle and environment. Like phosphorylation, with which it can compete, O-GlcNAcylation is reversible. This versatility is managed by OGT (O-GlcNAc transferase) that transfers the GlcNAc group and OGA (O-GlcNAcase) that removes it. Also, like its unsweetened counterpart, O-GlcNAcylation controls fundamental processes, e.g. protein fate, chromatin topology, DNA demethylation and, as recently revealed, circadian clock. Deregulation of O-GlcNAc dynamism may be involved in the emergence of cancers, neuronal and metabolic disorders such as Alzheimer's or diabetes respectively. This Research Topic in Frontiers in Endocrinology is the opportunity to celebrate the thirtieth anniversary of the discovery of "O-GlcNAc" by Gerald W. Hart. 2021-02-11T07:33:59Z 2021-02-11T07:33:59Z 2016-03-10 08:14:32 2015 book 18701 16648714 9782889195916 https://directory.doabooks.org/handle/20.500.12854/39892 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/30_years_old_O-GlcNAc_reaches_age_of_reason_-_Regulation_of_cell_signaling_and_metabolism_by_O-GlcN/573#nogo http://journal.frontiersin.org/researchtopic/2684/30-years-old-o-glcnac-reaches-age-of-reason---regulation-of-cell-signaling-and-metabolism-by-o-glcna Frontiers Media SA 10.3389/978-2-88919-591-6 10.3389/978-2-88919-591-6 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889195916 113 open access |
| spellingShingle | RC648-665 R5-920 nutrition Hexosamine biosynthetic pathway O GlcNAcylation OGA Inflammation Metabolism OGT Cell signaling epigenetics Cancer Tarik Issad Tony Lefebvre 30 years old: O-GlcNAc Reaches Age of Reason - Regulation of Cell Signaling and Metabolism by O-GlcNAcylation |
| title | 30 years old: O-GlcNAc Reaches Age of Reason - Regulation of Cell Signaling and Metabolism by O-GlcNAcylation |
| title_full | 30 years old: O-GlcNAc Reaches Age of Reason - Regulation of Cell Signaling and Metabolism by O-GlcNAcylation |
| title_fullStr | 30 years old: O-GlcNAc Reaches Age of Reason - Regulation of Cell Signaling and Metabolism by O-GlcNAcylation |
| title_full_unstemmed | 30 years old: O-GlcNAc Reaches Age of Reason - Regulation of Cell Signaling and Metabolism by O-GlcNAcylation |
| title_short | 30 years old: O-GlcNAc Reaches Age of Reason - Regulation of Cell Signaling and Metabolism by O-GlcNAcylation |
| title_sort | 30 years old o glcnac reaches age of reason regulation of cell signaling and metabolism by o glcnacylation |
| topic | RC648-665 R5-920 nutrition Hexosamine biosynthetic pathway O GlcNAcylation OGA Inflammation Metabolism OGT Cell signaling epigenetics Cancer |
| topic_facet | RC648-665 R5-920 nutrition Hexosamine biosynthetic pathway O GlcNAcylation OGA Inflammation Metabolism OGT Cell signaling epigenetics Cancer |
| url | 18701 |
| work_keys_str_mv | AT tarikissad 30yearsoldoglcnacreachesageofreasonregulationofcellsignalingandmetabolismbyoglcnacylation AT tonylefebvre 30yearsoldoglcnacreachesageofreasonregulationofcellsignalingandmetabolismbyoglcnacylation |