Adipokines 2.0
Once viewed solely as fat storage cells, adipocytes and their adipokines have now been proven to be central for human health. Understanding that overweight and obesity may increase the risk for various diseases requires detailed characterization of adipokine function. Weight gain, weight regain, and...
সংরক্ষণ করুন:
| প্রধান লেখক: | |
|---|---|
| বিন্যাস: | Online |
| ভাষা: | ইংরেজি |
| প্রকাশিত: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
|
| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | 45983 |
| ট্যাগগুলো: |
কোনো ট্যাগ নেই, প্রথমজন হিসাবে ট্যাগ করুন!
|
| _version_ | 1869514043999387648 |
|---|---|
| author | Büchler, Christa |
| author_browse | Büchler, Christa |
| author_facet | Büchler, Christa |
| author_sort | Büchler, Christa |
| collection | Directory of Open Access Books |
| description | Once viewed solely as fat storage cells, adipocytes and their adipokines have now been proven to be central for human health. Understanding that overweight and obesity may increase the risk for various diseases requires detailed characterization of adipokine function. Weight gain, weight regain, and fasting affect adipocyte health and accordingly their secretome. Different adipose tissue deposits exist and they vary in cellular composition and function. The evidence is strong of a role of adipokines in cancer, reproductive function, neurological diseases, cardiovascular diseases ,and rheumatoid arthritis. Adipokines are considered useful biomarkers for adipose tissue and metabolic health, and may be used as diagnostic tools in rheumatoid arthritis, cancer, or sepsis. This book contains 10 original articles and 9 review articles focusing on these bioactive peptides. Several articles deal with chemerin, an adipokine discovered more than 20 years ago. Data so far have resulted in promising insights related to its biological function. We are only beginning to understand the multiple roles of chemerin, the mechanisms regulating its activity, and the signaling pathways used by this chemokine. Adipokine receptor agonists and antagonists may result in the formulation of novel drugs and ultimately may lead to new therapeutic targets to be used in clinical practice. |
| format | Online |
| id | doab-20.500.12854ir-40131 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-401312024-03-30T23:21:33Z Adipokines 2.0 Büchler, Christa R5-920 RM1-950 n/a lipids cathepsins neurodegeneration tocilizumab SGBS adipocytes chemerin receptors cholesterol metabolically healthy obese energy metabolism adipose-brain axis EP3 receptor leptin rheumatoid arthritis excessive gestational weight gain in vitro fat regain secreted frizzled-related protein 5 PCOS EP4 receptor leukocyte exchange protein directly activated by cAMP isoform 2 (EPAC2) extracellular remodeling insulin osteoarthritis lipid metabolism fat mass Tango bioassay fatty liver free fatty acids label-free proteomic profiling interleukin(IL)-33 sick fat polycystic ovary syndrome early-life programming inflammation gestational diabetes glucose restriction adipokines neonatal anthropometry epicardial adipose tissue (EAT) oestrous cycle Cardiovascular Diseases (CVDs) triglycerides G protein-coupled receptor 1 testicular pathologies prognosis ovary ICU biologic activity preeclempsia adipokine critical illness early pregnancy myokine liver steatosis C-C chemokine receptor-like 2 testis stimulating growth factor 2 (ST2) pig fitness human granulosa cells obesity proteolysis annexins adipose tissue biomarker ghrelin brain health sepsis adiponectin rheumatic diseases chemokine-like receptor 1 follicular fluid glucose homeostasis resistin Nonalcoholic fatty liver disease prostaglandin E2 (PGE2) visceral fat microglia weight regain complement factors alpha-fetoprotein polycystic ovary morphology chemerin cancer depression hypertension hypothalamus thema EDItEUR::M Medicine and Nursing Once viewed solely as fat storage cells, adipocytes and their adipokines have now been proven to be central for human health. Understanding that overweight and obesity may increase the risk for various diseases requires detailed characterization of adipokine function. Weight gain, weight regain, and fasting affect adipocyte health and accordingly their secretome. Different adipose tissue deposits exist and they vary in cellular composition and function. The evidence is strong of a role of adipokines in cancer, reproductive function, neurological diseases, cardiovascular diseases ,and rheumatoid arthritis. Adipokines are considered useful biomarkers for adipose tissue and metabolic health, and may be used as diagnostic tools in rheumatoid arthritis, cancer, or sepsis. This book contains 10 original articles and 9 review articles focusing on these bioactive peptides. Several articles deal with chemerin, an adipokine discovered more than 20 years ago. Data so far have resulted in promising insights related to its biological function. We are only beginning to understand the multiple roles of chemerin, the mechanisms regulating its activity, and the signaling pathways used by this chemokine. Adipokine receptor agonists and antagonists may result in the formulation of novel drugs and ultimately may lead to new therapeutic targets to be used in clinical practice. 2021-02-11T07:42:39Z 2021-02-11T07:42:39Z 2020-06-09 16:38:57 2020 book 45983 9783039285860 9783039285877 https://directory.doabooks.org/handle/20.500.12854/40131 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/2157 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03928-587-7 10.3390/books978-3-03928-587-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039285860 9783039285877 406 open access |
| spellingShingle | R5-920 RM1-950 n/a lipids cathepsins neurodegeneration tocilizumab SGBS adipocytes chemerin receptors cholesterol metabolically healthy obese energy metabolism adipose-brain axis EP3 receptor leptin rheumatoid arthritis excessive gestational weight gain in vitro fat regain secreted frizzled-related protein 5 PCOS EP4 receptor leukocyte exchange protein directly activated by cAMP isoform 2 (EPAC2) extracellular remodeling insulin osteoarthritis lipid metabolism fat mass Tango bioassay fatty liver free fatty acids label-free proteomic profiling interleukin(IL)-33 sick fat polycystic ovary syndrome early-life programming inflammation gestational diabetes glucose restriction adipokines neonatal anthropometry epicardial adipose tissue (EAT) oestrous cycle Cardiovascular Diseases (CVDs) triglycerides G protein-coupled receptor 1 testicular pathologies prognosis ovary ICU biologic activity preeclempsia adipokine critical illness early pregnancy myokine liver steatosis C-C chemokine receptor-like 2 testis stimulating growth factor 2 (ST2) pig fitness human granulosa cells obesity proteolysis annexins adipose tissue biomarker ghrelin brain health sepsis adiponectin rheumatic diseases chemokine-like receptor 1 follicular fluid glucose homeostasis resistin Nonalcoholic fatty liver disease prostaglandin E2 (PGE2) visceral fat microglia weight regain complement factors alpha-fetoprotein polycystic ovary morphology chemerin cancer depression hypertension hypothalamus thema EDItEUR::M Medicine and Nursing Büchler, Christa Adipokines 2.0 |
| title | Adipokines 2.0 |
| title_full | Adipokines 2.0 |
| title_fullStr | Adipokines 2.0 |
| title_full_unstemmed | Adipokines 2.0 |
| title_short | Adipokines 2.0 |
| title_sort | adipokines 2 0 |
| topic | R5-920 RM1-950 n/a lipids cathepsins neurodegeneration tocilizumab SGBS adipocytes chemerin receptors cholesterol metabolically healthy obese energy metabolism adipose-brain axis EP3 receptor leptin rheumatoid arthritis excessive gestational weight gain in vitro fat regain secreted frizzled-related protein 5 PCOS EP4 receptor leukocyte exchange protein directly activated by cAMP isoform 2 (EPAC2) extracellular remodeling insulin osteoarthritis lipid metabolism fat mass Tango bioassay fatty liver free fatty acids label-free proteomic profiling interleukin(IL)-33 sick fat polycystic ovary syndrome early-life programming inflammation gestational diabetes glucose restriction adipokines neonatal anthropometry epicardial adipose tissue (EAT) oestrous cycle Cardiovascular Diseases (CVDs) triglycerides G protein-coupled receptor 1 testicular pathologies prognosis ovary ICU biologic activity preeclempsia adipokine critical illness early pregnancy myokine liver steatosis C-C chemokine receptor-like 2 testis stimulating growth factor 2 (ST2) pig fitness human granulosa cells obesity proteolysis annexins adipose tissue biomarker ghrelin brain health sepsis adiponectin rheumatic diseases chemokine-like receptor 1 follicular fluid glucose homeostasis resistin Nonalcoholic fatty liver disease prostaglandin E2 (PGE2) visceral fat microglia weight regain complement factors alpha-fetoprotein polycystic ovary morphology chemerin cancer depression hypertension hypothalamus thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RM1-950 n/a lipids cathepsins neurodegeneration tocilizumab SGBS adipocytes chemerin receptors cholesterol metabolically healthy obese energy metabolism adipose-brain axis EP3 receptor leptin rheumatoid arthritis excessive gestational weight gain in vitro fat regain secreted frizzled-related protein 5 PCOS EP4 receptor leukocyte exchange protein directly activated by cAMP isoform 2 (EPAC2) extracellular remodeling insulin osteoarthritis lipid metabolism fat mass Tango bioassay fatty liver free fatty acids label-free proteomic profiling interleukin(IL)-33 sick fat polycystic ovary syndrome early-life programming inflammation gestational diabetes glucose restriction adipokines neonatal anthropometry epicardial adipose tissue (EAT) oestrous cycle Cardiovascular Diseases (CVDs) triglycerides G protein-coupled receptor 1 testicular pathologies prognosis ovary ICU biologic activity preeclempsia adipokine critical illness early pregnancy myokine liver steatosis C-C chemokine receptor-like 2 testis stimulating growth factor 2 (ST2) pig fitness human granulosa cells obesity proteolysis annexins adipose tissue biomarker ghrelin brain health sepsis adiponectin rheumatic diseases chemokine-like receptor 1 follicular fluid glucose homeostasis resistin Nonalcoholic fatty liver disease prostaglandin E2 (PGE2) visceral fat microglia weight regain complement factors alpha-fetoprotein polycystic ovary morphology chemerin cancer depression hypertension hypothalamus thema EDItEUR::M Medicine and Nursing |
| url | 45983 |
| work_keys_str_mv | AT buchlerchrista adipokines20 |