Adult neurogenesis twenty years later: physiological function versus brain repair
The discovery that mammalian brains contain neural stem cells which perform adult neurogenesis - the production and integration of new neurons into mature neural circuits - has provided a fully new vision of neural plasticity. On a theoretical basis, this achievement opened new perspectives for ther...
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| Автори: | , |
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| Формат: | Online |
| Мова: | Англійська |
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Frontiers Media SA
2021
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| Онлайн доступ: | 17682 |
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| _version_ | 1869526270198415360 |
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| author | Paolo Peretto Luca Bonfanti |
| author_browse | Luca Bonfanti Paolo Peretto |
| author_facet | Paolo Peretto Luca Bonfanti |
| author_sort | Paolo Peretto |
| collection | Directory of Open Access Books |
| description | The discovery that mammalian brains contain neural stem cells which perform adult neurogenesis - the production and integration of new neurons into mature neural circuits - has provided a fully new vision of neural plasticity. On a theoretical basis, this achievement opened new perspectives for therapeutic approaches in restorative and regenerative neurology. Nevertheless, in spite of striking advancement concerning the molecular and cellular mechanisms which allow and regulate the neurogenic process, its exploitation in mammals for brain repair strategies remains unsolved. In non-mammalian vertebrates, adult neurogenesis also contributes to brain repair/regeneration. In mammals, neural stem cells do respond to pathological conditions in the so called "reactive neurogenesis", yet without substantial regenerative outcome. Why, even in the presence of stem cells in the brain, we lack an effective reparative outcome in terms of regenerative neurology, and which factors hamper the attainment of this goal? Essentially, what remains unanswered is the question whether (and how) physiological functions of adult neurogenesis in mammals can be exploited for brain repair purposes. |
| format | Online |
| id | doab-20.500.12854ir-40172 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-401722024-04-05T17:31:13Z Adult neurogenesis twenty years later: physiological function versus brain repair Paolo Peretto Luca Bonfanti RC321-571 Q1-390 Neurodegenerative Diseases structural plasticity brain repair Cell specification cell therapy cell migration brain evolution Neural Stem Cells Regenerative Medicine therapeutic approaches thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences The discovery that mammalian brains contain neural stem cells which perform adult neurogenesis - the production and integration of new neurons into mature neural circuits - has provided a fully new vision of neural plasticity. On a theoretical basis, this achievement opened new perspectives for therapeutic approaches in restorative and regenerative neurology. Nevertheless, in spite of striking advancement concerning the molecular and cellular mechanisms which allow and regulate the neurogenic process, its exploitation in mammals for brain repair strategies remains unsolved. In non-mammalian vertebrates, adult neurogenesis also contributes to brain repair/regeneration. In mammals, neural stem cells do respond to pathological conditions in the so called "reactive neurogenesis", yet without substantial regenerative outcome. Why, even in the presence of stem cells in the brain, we lack an effective reparative outcome in terms of regenerative neurology, and which factors hamper the attainment of this goal? Essentially, what remains unanswered is the question whether (and how) physiological functions of adult neurogenesis in mammals can be exploited for brain repair purposes. 2021-02-11T07:45:20Z 2021-02-11T07:45:20Z 2015-11-16 15:44:59 2015 book 17682 16648714 9782889194940 https://directory.doabooks.org/handle/20.500.12854/40172 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Adult_neurogenesis_twenty_years_later_physiological_function_versus_brain_repair/509#nogo http://journal.frontiersin.org/researchtopic/1785/adult-neurogenesis-twenty-years-later-physiological-function-versus-brain-repair Frontiers Media SA 10.3389/978-2-88919-494-0 10.3389/978-2-88919-494-0 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889194940 120 open access |
| spellingShingle | RC321-571 Q1-390 Neurodegenerative Diseases structural plasticity brain repair Cell specification cell therapy cell migration brain evolution Neural Stem Cells Regenerative Medicine therapeutic approaches thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Paolo Peretto Luca Bonfanti Adult neurogenesis twenty years later: physiological function versus brain repair |
| title | Adult neurogenesis twenty years later: physiological function versus brain repair |
| title_full | Adult neurogenesis twenty years later: physiological function versus brain repair |
| title_fullStr | Adult neurogenesis twenty years later: physiological function versus brain repair |
| title_full_unstemmed | Adult neurogenesis twenty years later: physiological function versus brain repair |
| title_short | Adult neurogenesis twenty years later: physiological function versus brain repair |
| title_sort | adult neurogenesis twenty years later physiological function versus brain repair |
| topic | RC321-571 Q1-390 Neurodegenerative Diseases structural plasticity brain repair Cell specification cell therapy cell migration brain evolution Neural Stem Cells Regenerative Medicine therapeutic approaches thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Neurodegenerative Diseases structural plasticity brain repair Cell specification cell therapy cell migration brain evolution Neural Stem Cells Regenerative Medicine therapeutic approaches thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 17682 |
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