Advances in Aspergillus fumigatus pathobiology
Aspergillus fumigatus is a human fungal pathogen that causes invasive aspergillosis (IA), a major infectious cause of death in the expanding population of immunocompromised individuals such as cancer patients and transplant recipients. The mortality of IA remains high (30-70%) and emerging resistanc...
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| Taal: | Engels |
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Frontiers Media SA
2021
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| author | Praveen R. Juvvadi Frederic Lamoth William J. Steinbach |
| author_browse | Frederic Lamoth Praveen R. Juvvadi William J. Steinbach |
| author_facet | Praveen R. Juvvadi Frederic Lamoth William J. Steinbach |
| author_sort | Praveen R. Juvvadi |
| collection | Directory of Open Access Books |
| description | Aspergillus fumigatus is a human fungal pathogen that causes invasive aspergillosis (IA), a major infectious cause of death in the expanding population of immunocompromised individuals such as cancer patients and transplant recipients. The mortality of IA remains high (30-70%) and emerging resistance to triazoles, the first-line antifungal drug class, is of particular concern. Second-line therapies for IA are limited by their toxicity (polyenes) or their lack of fungicidal activity (echinocandins). Identification of novel antifungal targets is an urgent need for improving the outcome of IA. A. fumigatus is a filamentous fungus exhibiting a complex developmental cycle and elaborated mechanisms of adaptation to allow the initiation and progression of infection in the human host. The fungal cell wall, with its unique and dynamic structure, is crucial for protecting cell integrity and evading the host immune system, also contributing to biofilm formation and virulence, and thus representing an ideal antifungal target. The emergence of azole resistance implies various and complex mechanisms that need to be further elucidated. Other important processes, such as biosynthetic pathways and toxin/metabolite production are important for fungal survival and propagation in the host environment, ultimately leading to disease. Moreover, the host immune response is a determinant factor in influencing the course of infection. The objective of this topic issue is to provide an overview of the recent advances in our understanding of A. fumigatus pathobiology and of IA pathogenesis to outline future research. |
| format | Online |
| id | doab-20.500.12854ir-40234 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-402342024-04-05T17:30:59Z Advances in Aspergillus fumigatus pathobiology Praveen R. Juvvadi Frederic Lamoth William J. Steinbach QR1-502 Q1-390 invasive aspergillosis Fungal cell wall Fungal Virulence Aspergillus fumigatus antifungal resistance thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) Aspergillus fumigatus is a human fungal pathogen that causes invasive aspergillosis (IA), a major infectious cause of death in the expanding population of immunocompromised individuals such as cancer patients and transplant recipients. The mortality of IA remains high (30-70%) and emerging resistance to triazoles, the first-line antifungal drug class, is of particular concern. Second-line therapies for IA are limited by their toxicity (polyenes) or their lack of fungicidal activity (echinocandins). Identification of novel antifungal targets is an urgent need for improving the outcome of IA. A. fumigatus is a filamentous fungus exhibiting a complex developmental cycle and elaborated mechanisms of adaptation to allow the initiation and progression of infection in the human host. The fungal cell wall, with its unique and dynamic structure, is crucial for protecting cell integrity and evading the host immune system, also contributing to biofilm formation and virulence, and thus representing an ideal antifungal target. The emergence of azole resistance implies various and complex mechanisms that need to be further elucidated. Other important processes, such as biosynthetic pathways and toxin/metabolite production are important for fungal survival and propagation in the host environment, ultimately leading to disease. Moreover, the host immune response is a determinant factor in influencing the course of infection. The objective of this topic issue is to provide an overview of the recent advances in our understanding of A. fumigatus pathobiology and of IA pathogenesis to outline future research. 2021-02-11T07:46:46Z 2021-02-11T07:46:46Z 2016-04-07 11:22:02 2016 book 18904 16648714 9782889197897 https://directory.doabooks.org/handle/20.500.12854/40234 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Advances_in_Aspergillus_fumigatus_Pathobiology/828#nogo http://journal.frontiersin.org/researchtopic/3334/advances-in-aspergillus-fumigatus-pathobiology Frontiers Media SA 10.3389/978-2-88919-789-7 10.3389/978-2-88919-789-7 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889197897 109 open access |
| spellingShingle | QR1-502 Q1-390 invasive aspergillosis Fungal cell wall Fungal Virulence Aspergillus fumigatus antifungal resistance thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) Praveen R. Juvvadi Frederic Lamoth William J. Steinbach Advances in Aspergillus fumigatus pathobiology |
| title | Advances in Aspergillus fumigatus pathobiology |
| title_full | Advances in Aspergillus fumigatus pathobiology |
| title_fullStr | Advances in Aspergillus fumigatus pathobiology |
| title_full_unstemmed | Advances in Aspergillus fumigatus pathobiology |
| title_short | Advances in Aspergillus fumigatus pathobiology |
| title_sort | advances in aspergillus fumigatus pathobiology |
| topic | QR1-502 Q1-390 invasive aspergillosis Fungal cell wall Fungal Virulence Aspergillus fumigatus antifungal resistance thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) |
| topic_facet | QR1-502 Q1-390 invasive aspergillosis Fungal cell wall Fungal Virulence Aspergillus fumigatus antifungal resistance thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) |
| url | 18904 |
| work_keys_str_mv | AT praveenrjuvvadi advancesinaspergillusfumigatuspathobiology AT fredericlamoth advancesinaspergillusfumigatuspathobiology AT williamjsteinbach advancesinaspergillusfumigatuspathobiology |