Advances in Mechanisms of Renal Fibrosis
Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-β (TGF-β) plays a key role. This eBook provides a comprehensive...
שמור ב:
| Main Authors: | , |
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| פורמט: | Online |
| שפה: | אנגלית |
| יצא לאור: |
Frontiers Media SA
2021
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| נושאים: | |
| גישה מקוונת: | 31910 |
| תגים: |
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| _version_ | 1869518237674242048 |
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| author | David J. Nikolic-Paterson Hui Y. Lan |
| author_browse | David J. Nikolic-Paterson Hui Y. Lan |
| author_facet | David J. Nikolic-Paterson Hui Y. Lan |
| author_sort | David J. Nikolic-Paterson |
| collection | Directory of Open Access Books |
| description | Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-β (TGF-β) plays a key role. This eBook provides a comprehensive update on TGF-β signalling pathways and introduces a range of cellular and molecular mechanisms involved in renal fibrosis both upstream and downstream of TGF-β. The wide variety of potential new targets described herein bodes well for the future development of effective therapies to tackle the major clinical problem of progressive renal fibrosis. |
| format | Online |
| id | doab-20.500.12854ir-40307 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-403072024-03-31T22:45:07Z Advances in Mechanisms of Renal Fibrosis David J. Nikolic-Paterson Hui Y. Lan QP1-981 Q1-390 TGF-beta fibroblast JNK miRNA Smad non-classical RAS BMP7 HDAC HIPK2 thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-β (TGF-β) plays a key role. This eBook provides a comprehensive update on TGF-β signalling pathways and introduces a range of cellular and molecular mechanisms involved in renal fibrosis both upstream and downstream of TGF-β. The wide variety of potential new targets described herein bodes well for the future development of effective therapies to tackle the major clinical problem of progressive renal fibrosis. 2021-02-11T07:49:19Z 2021-02-11T07:49:19Z 2019-01-23 14:53:42 2018 book 31910 16648714 9782889454990 https://directory.doabooks.org/handle/20.500.12854/40307 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/3106/advances-in-mechanisms-of-renal-fibrosis Frontiers Media SA 10.3389/978-2-88945-499-0 10.3389/978-2-88945-499-0 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889454990 84 open access |
| spellingShingle | QP1-981 Q1-390 TGF-beta fibroblast JNK miRNA Smad non-classical RAS BMP7 HDAC HIPK2 thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology David J. Nikolic-Paterson Hui Y. Lan Advances in Mechanisms of Renal Fibrosis |
| title | Advances in Mechanisms of Renal Fibrosis |
| title_full | Advances in Mechanisms of Renal Fibrosis |
| title_fullStr | Advances in Mechanisms of Renal Fibrosis |
| title_full_unstemmed | Advances in Mechanisms of Renal Fibrosis |
| title_short | Advances in Mechanisms of Renal Fibrosis |
| title_sort | advances in mechanisms of renal fibrosis |
| topic | QP1-981 Q1-390 TGF-beta fibroblast JNK miRNA Smad non-classical RAS BMP7 HDAC HIPK2 thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| topic_facet | QP1-981 Q1-390 TGF-beta fibroblast JNK miRNA Smad non-classical RAS BMP7 HDAC HIPK2 thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| url | 31910 |
| work_keys_str_mv | AT davidjnikolicpaterson advancesinmechanismsofrenalfibrosis AT huiylan advancesinmechanismsofrenalfibrosis |