Advances in Micro-Bioreactor Design for Organ Cell Studies
Micro-bioreactors offer unique opportunities to study biological systems under fluidic conditions. The concept of micro-bioreactors suggests that biological reaction conditions on a large scale can be scaled down to micro-volumes while maintaining performance and functionality. Models and operation...
Bewaard in:
| Hoofdauteur: | |
|---|---|
| Formaat: | Online |
| Taal: | Engels |
| Gepubliceerd in: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
|
| Onderwerpen: | |
| Online toegang: | 29757 |
| Tags: |
Geen labels, Wees de eerste die dit record labelt!
|
| _version_ | 1869522157464190976 |
|---|---|
| author | Carl-Fredrik Mandenius (Ed.) |
| author_browse | Carl-Fredrik Mandenius (Ed.) |
| author_facet | Carl-Fredrik Mandenius (Ed.) |
| author_sort | Carl-Fredrik Mandenius (Ed.) |
| collection | Directory of Open Access Books |
| description | Micro-bioreactors offer unique opportunities to study biological systems under fluidic conditions. The concept of micro-bioreactors suggests that biological reaction conditions on a large scale can be scaled down to micro-volumes while maintaining performance and functionality. Models and operation principles can be simulated at a smaller scale, either by scaling down organs in the human body, or using bioreactors for the production of biologics. This book highlights these issues with a strong focus on new engineering design. The initial chapters cover the conceptual design of microbioreactors and organ-on-chips, and the role of microbioreactors in tissue engineering for clinical and therapeutic targets. Two chapters are dedicated to microbioreactors for implementing tumor models. Other chapters discuss three-dimensional models for hepatic and cardiac cells for toxicity testing and drug evaluation. Finally, the design of organ chips for cartilage scaffolds and the integration of sensors are covered in separate chapters. We believe the book will have substantial value for researchers active in bioreactor engineering, drug development and cell physiology, as well as readers interested in these topics. |
| format | Online |
| id | doab-20.500.12854ir-40309 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-403092024-04-01T14:14:57Z Advances in Micro-Bioreactor Design for Organ Cell Studies Carl-Fredrik Mandenius (Ed.) RM1-950 microbioreactor design drug testing liver-on-a-chip bioprocess development in vitro assay toxicity testing heart-on-a-chip 3D models tumour-on-a-chip thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Micro-bioreactors offer unique opportunities to study biological systems under fluidic conditions. The concept of micro-bioreactors suggests that biological reaction conditions on a large scale can be scaled down to micro-volumes while maintaining performance and functionality. Models and operation principles can be simulated at a smaller scale, either by scaling down organs in the human body, or using bioreactors for the production of biologics. This book highlights these issues with a strong focus on new engineering design. The initial chapters cover the conceptual design of microbioreactors and organ-on-chips, and the role of microbioreactors in tissue engineering for clinical and therapeutic targets. Two chapters are dedicated to microbioreactors for implementing tumor models. Other chapters discuss three-dimensional models for hepatic and cardiac cells for toxicity testing and drug evaluation. Finally, the design of organ chips for cartilage scaffolds and the integration of sensors are covered in separate chapters. We believe the book will have substantial value for researchers active in bioreactor engineering, drug development and cell physiology, as well as readers interested in these topics. 2021-02-11T07:49:22Z 2021-02-11T07:49:22Z 2018-12-06 11:44:20 2018 book 29757 9783038972327 9783038972334 https://directory.doabooks.org/handle/20.500.12854/40309 eng image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International https://www.mdpi.com/books/pdfview/book/1030 https://play.google.com/books/publish/a/14935057684283403269#details/ISBN:9783038972334 https://www.mdpi.com/books/pdfview/book/1030 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03897-232-7 10.3390/books978-3-03897-232-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038972327 9783038972334 168 open access |
| spellingShingle | RM1-950 microbioreactor design drug testing liver-on-a-chip bioprocess development in vitro assay toxicity testing heart-on-a-chip 3D models tumour-on-a-chip thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Carl-Fredrik Mandenius (Ed.) Advances in Micro-Bioreactor Design for Organ Cell Studies |
| title | Advances in Micro-Bioreactor Design for Organ Cell Studies |
| title_full | Advances in Micro-Bioreactor Design for Organ Cell Studies |
| title_fullStr | Advances in Micro-Bioreactor Design for Organ Cell Studies |
| title_full_unstemmed | Advances in Micro-Bioreactor Design for Organ Cell Studies |
| title_short | Advances in Micro-Bioreactor Design for Organ Cell Studies |
| title_sort | advances in micro bioreactor design for organ cell studies |
| topic | RM1-950 microbioreactor design drug testing liver-on-a-chip bioprocess development in vitro assay toxicity testing heart-on-a-chip 3D models tumour-on-a-chip thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | RM1-950 microbioreactor design drug testing liver-on-a-chip bioprocess development in vitro assay toxicity testing heart-on-a-chip 3D models tumour-on-a-chip thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | 29757 |
| work_keys_str_mv | AT carlfredrikmandeniused advancesinmicrobioreactordesignfororgancellstudies |