Aging, neurogenesis and neuroinflammation in hearing loss and protection
Worldwide, 278 million people are estimated to have moderate to profound hearing loss. Age-related hearing loss, also known as presbyacusis, affects approximately half of the population over 60 years old, making it the second most common cause of disability in older people. Hearing loss occurs when...
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| Autores principales: | , , |
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| Formato: | Online |
| Lenguaje: | inglés |
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Frontiers Media SA
2021
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| Acceso en línea: | 19547 |
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| _version_ | 1869527551301386240 |
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| author | Marta Magarinos Isabel Varela-Nieto Marta Milo |
| author_browse | Isabel Varela-Nieto Marta Magarinos Marta Milo |
| author_facet | Marta Magarinos Isabel Varela-Nieto Marta Milo |
| author_sort | Marta Magarinos |
| collection | Directory of Open Access Books |
| description | Worldwide, 278 million people are estimated to have moderate to profound hearing loss. Age-related hearing loss, also known as presbyacusis, affects approximately half of the population over 60 years old, making it the second most common cause of disability in older people. Hearing loss occurs when the sensory cells and neurons of the cochlea degenerate and die. The vestibular system, which holds the sense of balance, shares a common embryonic origin with the cochlea and together conform the inner ear. Balance problems are a trait of ageing to the point that balance ability is considered a sensor of physical decline and vestibular degeneration is the most common cause of falls in the elderly. Still the molecular bases of ageing in the vestibular system have not been studied in detail. Genetic and environmental factors contribute to the progression of age-related hearing loss (ARHL). Being noise the main environmental noxious agent for human hearing in the industrialized societies. There is no restorative treatment for deafness but functional replacement by means of prosthesis. Therefore, prevention and treatment of hearing loss is an unmet medical need. To develop innovative medical strategies against hearing loss, it is critical to understand the causes of ARHL and the essential pathways responsible for the manifestation of this complex disease. In this research topic, experts will discuss the stages and molecular elements of the damage and repair processes involved in ARHL, from cellular processes to molecules involved in aging. Oxidative stress takes a central stage as an essential element in the progression of injury and cell loss, and a target for cell protection strategies. Finally, the mechanisms of action and the potential of novel therapies for hair cell repair and protection will be discussed along with drug delivery strategies. |
| format | Online |
| id | doab-20.500.12854ir-40472 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-404722024-04-05T17:29:37Z Aging, neurogenesis and neuroinflammation in hearing loss and protection Marta Magarinos Isabel Varela-Nieto Marta Milo RC321-571 Q1-390 TGF-beta Noise Hair cells redox balance spiral ganglion neurons Drug delivery ARHL Auditory Cortex Lipid homeostasis Inner ear thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Worldwide, 278 million people are estimated to have moderate to profound hearing loss. Age-related hearing loss, also known as presbyacusis, affects approximately half of the population over 60 years old, making it the second most common cause of disability in older people. Hearing loss occurs when the sensory cells and neurons of the cochlea degenerate and die. The vestibular system, which holds the sense of balance, shares a common embryonic origin with the cochlea and together conform the inner ear. Balance problems are a trait of ageing to the point that balance ability is considered a sensor of physical decline and vestibular degeneration is the most common cause of falls in the elderly. Still the molecular bases of ageing in the vestibular system have not been studied in detail. Genetic and environmental factors contribute to the progression of age-related hearing loss (ARHL). Being noise the main environmental noxious agent for human hearing in the industrialized societies. There is no restorative treatment for deafness but functional replacement by means of prosthesis. Therefore, prevention and treatment of hearing loss is an unmet medical need. To develop innovative medical strategies against hearing loss, it is critical to understand the causes of ARHL and the essential pathways responsible for the manifestation of this complex disease. In this research topic, experts will discuss the stages and molecular elements of the damage and repair processes involved in ARHL, from cellular processes to molecules involved in aging. Oxidative stress takes a central stage as an essential element in the progression of injury and cell loss, and a target for cell protection strategies. Finally, the mechanisms of action and the potential of novel therapies for hair cell repair and protection will be discussed along with drug delivery strategies. 2021-02-11T07:56:50Z 2021-02-11T07:56:50Z 2016-08-16 10:34:25 2015 book 19547 16648714 9782889196449 https://directory.doabooks.org/handle/20.500.12854/40472 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Aging_neurogenesis_and_neuroinflammation_in_hearing_loss_and_protection/689#nogo http://journal.frontiersin.org/researchtopic/2966/aging-neurogenesis-and-neuroinflammation-in-hearing-loss-and-protection Frontiers Media SA 10.3389/978-2-88919-644-9 10.3389/978-2-88919-644-9 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889196449 151 open access |
| spellingShingle | RC321-571 Q1-390 TGF-beta Noise Hair cells redox balance spiral ganglion neurons Drug delivery ARHL Auditory Cortex Lipid homeostasis Inner ear thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Marta Magarinos Isabel Varela-Nieto Marta Milo Aging, neurogenesis and neuroinflammation in hearing loss and protection |
| title | Aging, neurogenesis and neuroinflammation in hearing loss and protection |
| title_full | Aging, neurogenesis and neuroinflammation in hearing loss and protection |
| title_fullStr | Aging, neurogenesis and neuroinflammation in hearing loss and protection |
| title_full_unstemmed | Aging, neurogenesis and neuroinflammation in hearing loss and protection |
| title_short | Aging, neurogenesis and neuroinflammation in hearing loss and protection |
| title_sort | aging neurogenesis and neuroinflammation in hearing loss and protection |
| topic | RC321-571 Q1-390 TGF-beta Noise Hair cells redox balance spiral ganglion neurons Drug delivery ARHL Auditory Cortex Lipid homeostasis Inner ear thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 TGF-beta Noise Hair cells redox balance spiral ganglion neurons Drug delivery ARHL Auditory Cortex Lipid homeostasis Inner ear thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 19547 |
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