Amyloid-beta clearance in Alzheimer's disease
Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer’s disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogenesis a...
Tallennettuna:
| Päätekijät: | , |
|---|---|
| Aineistotyyppi: | Online |
| Kieli: | englanti |
| Julkaistu: |
Frontiers Media SA
2021
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| Aiheet: | |
| Linkit: | 18589 |
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| _version_ | 1869520685875855360 |
|---|---|
| author | Robert Marr Eliezer Masliah |
| author_browse | Eliezer Masliah Robert Marr |
| author_facet | Robert Marr Eliezer Masliah |
| author_sort | Robert Marr |
| collection | Directory of Open Access Books |
| description | Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer’s disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to Aß clearance in AD. The topics covered include proteases that degrade Aß and their localization, regulation, and functions. This topic also covers issues related to clearance through uptake by glia and through low-density lipoprotein (LDL) receptor mediated mechanisms. Signal transduction related to AD pathology and clearance is also addressed. Finally, immunotherapy and other novel therapeutic approaches are discussed. |
| format | Online |
| id | doab-20.500.12854ir-40785 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-407852024-04-05T12:36:06Z Amyloid-beta clearance in Alzheimer's disease Robert Marr Eliezer Masliah RC321-571 Q1-390 amyloid-beta Signal Transduction Proteases LDL receptors Clearance Alzheimer's disease thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer’s disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to Aß clearance in AD. The topics covered include proteases that degrade Aß and their localization, regulation, and functions. This topic also covers issues related to clearance through uptake by glia and through low-density lipoprotein (LDL) receptor mediated mechanisms. Signal transduction related to AD pathology and clearance is also addressed. Finally, immunotherapy and other novel therapeutic approaches are discussed. 2021-02-11T08:09:13Z 2021-02-11T08:09:13Z 2016-02-05 17:24:33 2015 book 18589 16648714 9782889194438 https://directory.doabooks.org/handle/20.500.12854/40785 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Amyloid-beta_clearance_in_Alzheimer%E2%80%99s_disease/472 http://journal.frontiersin.org/researchtopic/2235/amyloid-beta-clearance-in-alzheimers-disease Frontiers Media SA 10.3389/978-2-88919-443-8 10.3389/978-2-88919-443-8 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889194438 111 open access |
| spellingShingle | RC321-571 Q1-390 amyloid-beta Signal Transduction Proteases LDL receptors Clearance Alzheimer's disease thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Robert Marr Eliezer Masliah Amyloid-beta clearance in Alzheimer's disease |
| title | Amyloid-beta clearance in Alzheimer's disease |
| title_full | Amyloid-beta clearance in Alzheimer's disease |
| title_fullStr | Amyloid-beta clearance in Alzheimer's disease |
| title_full_unstemmed | Amyloid-beta clearance in Alzheimer's disease |
| title_short | Amyloid-beta clearance in Alzheimer's disease |
| title_sort | amyloid beta clearance in alzheimer s disease |
| topic | RC321-571 Q1-390 amyloid-beta Signal Transduction Proteases LDL receptors Clearance Alzheimer's disease thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 amyloid-beta Signal Transduction Proteases LDL receptors Clearance Alzheimer's disease thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 18589 |
| work_keys_str_mv | AT robertmarr amyloidbetaclearanceinalzheimersdisease AT eliezermasliah amyloidbetaclearanceinalzheimersdisease |