Antimicrobial Peptides
Antimicrobial peptides (AMPs) are gene-encoded, ancient (and important) mediators of innate host defense that exert direct or indirect antimicrobial action as well as possessing other important biologic activities (e.g., neutralization of endotoxin and anti-biofilm action) that help to protect verte...
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| Үндсэн зохиолч: | |
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| Формат: | Online |
| Хэл сонгох: | англи |
| Хэвлэсэн: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Нөхцлүүд: | |
| Онлайн хандалт: | 17523 |
| Шошгууд: |
Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!
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| _version_ | 1869524910812954624 |
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| author | William M. Shafer (Ed.) |
| author_browse | William M. Shafer (Ed.) |
| author_facet | William M. Shafer (Ed.) |
| author_sort | William M. Shafer (Ed.) |
| collection | Directory of Open Access Books |
| description | Antimicrobial peptides (AMPs) are gene-encoded, ancient (and important) mediators of innate host defense that exert direct or indirect antimicrobial action as well as possessing other important biologic activities (e.g., neutralization of endotoxin and anti-biofilm action) that help to protect vertebrates, invertebrates and plants from invading pathogens. While the emergence of multi-antibiotic resistant pathogens (and the desperate need to develop new anti-infectives) has been a recent force driving the field, interest in AMPs has an earlier origin in studies of how phagocytes kill bacteria by oxygen-independent processes. AMPs responsible for such killing of microbes by rabbit and human neutrophils were later purified by Ganz, Selsted and Lehrer, which they termed defensins; at the time of this writing, literally thousands of defensin-based publications can be found in the scientific literature! The initial reports on defensins and the earlier report by Boman’s group on the purification and action of an insect AMP represented a historical and defining point for the AMP field as they, in hindsight, demanded the recognition of AMP research as a unique discipline that has important linkages to other important fields of medicine, especially those of microbiology, infectious diseases and immunology. On a personal note, I remember conferences on phagocytes and host defense in the early 1980s where the topic of AMPs was relegated to one short session in a five day period! Now, we have hundreds of international “AMPologists” with expertise in chemistry, biochemistry, molecular and structural biology, cell biology, microbiology, pharmacology, or medicine who have built their research careers around AMPs and can now attend international conferences dedicated to advances in AMP research. |
| format | Online |
| id | doab-20.500.12854ir-40965 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-409652022-01-31T10:09:53Z Antimicrobial Peptides William M. Shafer (Ed.) molecular biology synthesis bacterial diseases regulation inflammation host defense structure-function immune-modulation evolution antimicrobial peptides Antimicrobial peptides (AMPs) are gene-encoded, ancient (and important) mediators of innate host defense that exert direct or indirect antimicrobial action as well as possessing other important biologic activities (e.g., neutralization of endotoxin and anti-biofilm action) that help to protect vertebrates, invertebrates and plants from invading pathogens. While the emergence of multi-antibiotic resistant pathogens (and the desperate need to develop new anti-infectives) has been a recent force driving the field, interest in AMPs has an earlier origin in studies of how phagocytes kill bacteria by oxygen-independent processes. AMPs responsible for such killing of microbes by rabbit and human neutrophils were later purified by Ganz, Selsted and Lehrer, which they termed defensins; at the time of this writing, literally thousands of defensin-based publications can be found in the scientific literature! The initial reports on defensins and the earlier report by Boman’s group on the purification and action of an insect AMP represented a historical and defining point for the AMP field as they, in hindsight, demanded the recognition of AMP research as a unique discipline that has important linkages to other important fields of medicine, especially those of microbiology, infectious diseases and immunology. On a personal note, I remember conferences on phagocytes and host defense in the early 1980s where the topic of AMPs was relegated to one short session in a five day period! Now, we have hundreds of international “AMPologists” with expertise in chemistry, biochemistry, molecular and structural biology, cell biology, microbiology, pharmacology, or medicine who have built their research careers around AMPs and can now attend international conferences dedicated to advances in AMP research. 2021-02-11T08:15:20Z 2021-02-11T08:15:20Z 2015-10-22 10:29:38 2015 book 17523 9783038420736 9783038420729 https://directory.doabooks.org/handle/20.500.12854/40965 eng application/octet-stream Attribution 4.0 International http://books.mdpi.com/pdfview/book/140 http://books.mdpi.com/pdfview/book/140 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03842-073-6 10.3390/books978-3-03842-073-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038420736 9783038420729 336 open access |
| spellingShingle | molecular biology synthesis bacterial diseases regulation inflammation host defense structure-function immune-modulation evolution antimicrobial peptides William M. Shafer (Ed.) Antimicrobial Peptides |
| title | Antimicrobial Peptides |
| title_full | Antimicrobial Peptides |
| title_fullStr | Antimicrobial Peptides |
| title_full_unstemmed | Antimicrobial Peptides |
| title_short | Antimicrobial Peptides |
| title_sort | antimicrobial peptides |
| topic | molecular biology synthesis bacterial diseases regulation inflammation host defense structure-function immune-modulation evolution antimicrobial peptides |
| topic_facet | molecular biology synthesis bacterial diseases regulation inflammation host defense structure-function immune-modulation evolution antimicrobial peptides |
| url | 17523 |
| work_keys_str_mv | AT williammshafered antimicrobialpeptides |