Antimicrobial peptides and Complement - Maximising the inflammatory response
Antimicrobial peptides and complement are distinct components of the innate immune defence. While antimicrobial peptides, after cleavage of a preproprotein, have the ability to insert directly in non host membranes, complement requires a sequential enzymatic activation in the fluid phase in order to...
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| Formato: | Online |
| Idioma: | inglés |
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Frontiers Media SA
2021
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| Subjects: | |
| Acceso en liña: | 18862 |
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| _version_ | 1869518431536021504 |
|---|---|
| author | Cordula M. Stover |
| author_browse | Cordula M. Stover |
| author_facet | Cordula M. Stover |
| author_sort | Cordula M. Stover |
| collection | Directory of Open Access Books |
| description | Antimicrobial peptides and complement are distinct components of the innate immune defence. While antimicrobial peptides, after cleavage of a preproprotein, have the ability to insert directly in non host membranes, complement requires a sequential enzymatic activation in the fluid phase in order to produce a transmembrane membrane attack complex. Its insertion is controlled by membrane bound regulators. Deficiencies are described for both effectors and relate to increased susceptibility of infection. In addition, however, antimicrobial peptides and complement each influence the activity of inflammatory cells as recent data in the respective research areas shows. This series of articles draws together for the entities of antimicrobial peptides and complement a balance of contributions in the areas of evolution, roles, functions and preclinical applications. By comparing and contrasting antimicrobial peptides and complement, greater cross-disciplinary appreciation will be derived for their individual and overlapping spectra of activity, circumstances of activation and their general ability to more completely inform the inflammatory and cellular response. |
| format | Online |
| id | doab-20.500.12854ir-40966 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-409662024-03-30T23:22:18Z Antimicrobial peptides and Complement - Maximising the inflammatory response Cordula M. Stover R5-920 RC581-607 Disease regulation Health system-specific complement antimicrobial peptides thema EDItEUR::M Medicine and Nursing Antimicrobial peptides and complement are distinct components of the innate immune defence. While antimicrobial peptides, after cleavage of a preproprotein, have the ability to insert directly in non host membranes, complement requires a sequential enzymatic activation in the fluid phase in order to produce a transmembrane membrane attack complex. Its insertion is controlled by membrane bound regulators. Deficiencies are described for both effectors and relate to increased susceptibility of infection. In addition, however, antimicrobial peptides and complement each influence the activity of inflammatory cells as recent data in the respective research areas shows. This series of articles draws together for the entities of antimicrobial peptides and complement a balance of contributions in the areas of evolution, roles, functions and preclinical applications. By comparing and contrasting antimicrobial peptides and complement, greater cross-disciplinary appreciation will be derived for their individual and overlapping spectra of activity, circumstances of activation and their general ability to more completely inform the inflammatory and cellular response. 2021-02-11T08:16:32Z 2021-02-11T08:16:32Z 2016-04-07 11:22:02 2015 book 18862 16648714 9782889197378 https://directory.doabooks.org/handle/20.500.12854/40966 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Antimicrobial_Peptides_and_Complement__Maximising_the_Inflammatory_Response/743 http://journal.frontiersin.org/researchtopic/2912/antimicrobial-peptides-and-complement---maximising-the-inflammatory-response Frontiers Media SA 10.3389/978-2-88919-737-8 10.3389/978-2-88919-737-8 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889197378 157 open access |
| spellingShingle | R5-920 RC581-607 Disease regulation Health system-specific complement antimicrobial peptides thema EDItEUR::M Medicine and Nursing Cordula M. Stover Antimicrobial peptides and Complement - Maximising the inflammatory response |
| title | Antimicrobial peptides and Complement - Maximising the inflammatory response |
| title_full | Antimicrobial peptides and Complement - Maximising the inflammatory response |
| title_fullStr | Antimicrobial peptides and Complement - Maximising the inflammatory response |
| title_full_unstemmed | Antimicrobial peptides and Complement - Maximising the inflammatory response |
| title_short | Antimicrobial peptides and Complement - Maximising the inflammatory response |
| title_sort | antimicrobial peptides and complement maximising the inflammatory response |
| topic | R5-920 RC581-607 Disease regulation Health system-specific complement antimicrobial peptides thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 Disease regulation Health system-specific complement antimicrobial peptides thema EDItEUR::M Medicine and Nursing |
| url | 18862 |
| work_keys_str_mv | AT cordulamstover antimicrobialpeptidesandcomplementmaximisingtheinflammatoryresponse |