Antimicrobial Resistance and Virulence Common Mechanisms

Multiple relationships exist between antimicrobial resistance and bacterial virulence, and the spread of clones combining multiple antibiotic resistance and a high virulence level is an increasing problem. It was previously described how mutation-driven or horizontally acquired resistance mechanisms...

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Opis bibliograficzny
Główni autorzy: Etienne Giraud, Axel Cloeckaert, Ivan Rychlik
Format: Online
Język:angielski
Wydane: Frontiers Media SA 2021
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Dostęp online:23486
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Opis
Streszczenie:Multiple relationships exist between antimicrobial resistance and bacterial virulence, and the spread of clones combining multiple antibiotic resistance and a high virulence level is an increasing problem. It was previously described how mutation-driven or horizontally acquired resistance mechanisms can also have effects on virulence. It was also reported that mobile genetic elements often carry both resistance determinants and virulence-modulating genes, which favors the co-selection of both traits. In the present volume, we present a collection of articles which document additional aspects of the interactions between antimicrobial resistance and virulence in bacteria, and describe their potential therapeutic consequences.