Application of Antigen Cross-Presentation Research into Patient Care
The activation of adaptive immune responses requires the processing and presentation of protein antigens to lymphocytes. Especially dendritic cells are effective at display of antigen-derived peptides in the form of immunogenic peptide/MHC complexes to CD4 and CD8-positive T cells, and can stimulate...
में बचाया:
| मुख्य लेखक: | |
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| स्वरूप: | Online |
| भाषा: | अंग्रेज़ी |
| प्रकाशित: |
Frontiers Media SA
2021
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| विषय: | |
| ऑनलाइन पहुंच: | 23998 |
| टैग: |
कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!
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| _version_ | 1869530507949113344 |
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| author | Marianne Boes |
| author_browse | Marianne Boes |
| author_facet | Marianne Boes |
| author_sort | Marianne Boes |
| collection | Directory of Open Access Books |
| description | The activation of adaptive immune responses requires the processing and presentation of protein antigens to lymphocytes. Especially dendritic cells are effective at display of antigen-derived peptides in the form of immunogenic peptide/MHC complexes to CD4 and CD8-positive T cells, and can stimulate even naive T cells to clonally expand. During the last 40 years, mechanisms that facilitate antigen processing and presentation were clarified, mostly from work in cell lines and mouse models. From mouse-based work, it is now clear that dendritic cells represent a collection of specialized cell subsets that are particularly well endowed to stimulate antigen transport to distinct tissue locations, to transfer antigens between cellular subsets or to trigger T cell responses. Dendritic cell subsets hold great promise for therapeutic application, for example as dendritic cell-based vaccines to bolster immune responses against viruses or malignant growths. Hurdles remain that preclude the efficient application of high quality pre-clinical research into standardized patient care. In this research topic, efforts in dendritic cell research and dendritic cell-based vaccines are discussed, from both pre-clinical and application points of view. |
| format | Online |
| id | doab-20.500.12854ir-41040 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-410402024-03-31T13:10:14Z Application of Antigen Cross-Presentation Research into Patient Care Marianne Boes R5-920 RC581-607 clinical translation cross-presentation Vaccination Immunotherapy dendritic cell thema EDItEUR::M Medicine and Nursing The activation of adaptive immune responses requires the processing and presentation of protein antigens to lymphocytes. Especially dendritic cells are effective at display of antigen-derived peptides in the form of immunogenic peptide/MHC complexes to CD4 and CD8-positive T cells, and can stimulate even naive T cells to clonally expand. During the last 40 years, mechanisms that facilitate antigen processing and presentation were clarified, mostly from work in cell lines and mouse models. From mouse-based work, it is now clear that dendritic cells represent a collection of specialized cell subsets that are particularly well endowed to stimulate antigen transport to distinct tissue locations, to transfer antigens between cellular subsets or to trigger T cell responses. Dendritic cell subsets hold great promise for therapeutic application, for example as dendritic cell-based vaccines to bolster immune responses against viruses or malignant growths. Hurdles remain that preclude the efficient application of high quality pre-clinical research into standardized patient care. In this research topic, efforts in dendritic cell research and dendritic cell-based vaccines are discussed, from both pre-clinical and application points of view. 2021-02-11T08:18:33Z 2021-02-11T08:18:33Z 2017-10-13 14:57:01 2017 book 23998 16648714 9782889451913 https://directory.doabooks.org/handle/20.500.12854/41040 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Application_of_Antigen_Cross-Presentation_Research_into_Patient_Care/1200 http://journal.frontiersin.org/researchtopic/1985/application-of-antigen-cross-presentation-research-into-patient-care Frontiers Media SA 10.3389/978-2-88945-191-3 10.3389/978-2-88945-191-3 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889451913 124 open access |
| spellingShingle | R5-920 RC581-607 clinical translation cross-presentation Vaccination Immunotherapy dendritic cell thema EDItEUR::M Medicine and Nursing Marianne Boes Application of Antigen Cross-Presentation Research into Patient Care |
| title | Application of Antigen Cross-Presentation Research into Patient Care |
| title_full | Application of Antigen Cross-Presentation Research into Patient Care |
| title_fullStr | Application of Antigen Cross-Presentation Research into Patient Care |
| title_full_unstemmed | Application of Antigen Cross-Presentation Research into Patient Care |
| title_short | Application of Antigen Cross-Presentation Research into Patient Care |
| title_sort | application of antigen cross presentation research into patient care |
| topic | R5-920 RC581-607 clinical translation cross-presentation Vaccination Immunotherapy dendritic cell thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 clinical translation cross-presentation Vaccination Immunotherapy dendritic cell thema EDItEUR::M Medicine and Nursing |
| url | 23998 |
| work_keys_str_mv | AT marianneboes applicationofantigencrosspresentationresearchintopatientcare |