Aptamers
Aptamers are in vitro selected oligonucleotides capable of specific, high-affinity binding to a wide variety of target molecules. These features enable their application in diagnostics, therapeutics, targeted delivery, fluorescence imaging, and biosensing. Aptamers are isolated via the systematic ev...
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| Үндсэн зохиолчид: | , , |
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| Формат: | Online |
| Хэл сонгох: | англи |
| Хэвлэсэн: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Нөхцлүүд: | |
| Онлайн хандалт: | 27501 |
| Шошгууд: |
Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!
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| _version_ | 1869516098378924032 |
|---|---|
| author | Andrew Brian Kinghorn (Ed.) Yee-Wai Cheung (Ed.) Julian Alexander Tanner (Ed.) |
| author_browse | Andrew Brian Kinghorn (Ed.) Julian Alexander Tanner (Ed.) Yee-Wai Cheung (Ed.) |
| author_facet | Andrew Brian Kinghorn (Ed.) Yee-Wai Cheung (Ed.) Julian Alexander Tanner (Ed.) |
| author_sort | Andrew Brian Kinghorn (Ed.) |
| collection | Directory of Open Access Books |
| description | Aptamers are in vitro selected oligonucleotides capable of specific, high-affinity binding to a wide variety of target molecules. These features enable their application in diagnostics, therapeutics, targeted delivery, fluorescence imaging, and biosensing. Aptamers are isolated via the systematic evolution of ligands by exponential enrichment (SELEX), an iterative cycle of selection and amplification steps that enriches a randomly synthesised oligonucleotide library to a pool of specific, high-affinity aptamers. Since the inception of aptamers in 1990, the methods by which aptamers are selected have been improved, yielding a robust system capable of producing aptamers rapidly and at low cost. Recently, there has been an explosion in the field of aptamers including innovations in enhanced selection strategies, bioinformatics approaches, riboswitches, unnatural base pairs, nucleic acid nanostructures, and DNAzymes. This book combines excellent reviews with primary research articles to provide multidisciplinary perspectives on the frontiers of aptamer science in 2018. |
| format | Online |
| id | doab-20.500.12854ir-41140 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-411402024-04-05T12:31:55Z Aptamers Andrew Brian Kinghorn (Ed.) Yee-Wai Cheung (Ed.) Julian Alexander Tanner (Ed.) QH301-705.5 riboswitch DNAzyme aptamer SELEX thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Aptamers are in vitro selected oligonucleotides capable of specific, high-affinity binding to a wide variety of target molecules. These features enable their application in diagnostics, therapeutics, targeted delivery, fluorescence imaging, and biosensing. Aptamers are isolated via the systematic evolution of ligands by exponential enrichment (SELEX), an iterative cycle of selection and amplification steps that enriches a randomly synthesised oligonucleotide library to a pool of specific, high-affinity aptamers. Since the inception of aptamers in 1990, the methods by which aptamers are selected have been improved, yielding a robust system capable of producing aptamers rapidly and at low cost. Recently, there has been an explosion in the field of aptamers including innovations in enhanced selection strategies, bioinformatics approaches, riboswitches, unnatural base pairs, nucleic acid nanostructures, and DNAzymes. This book combines excellent reviews with primary research articles to provide multidisciplinary perspectives on the frontiers of aptamer science in 2018. 2021-02-11T08:22:33Z 2021-02-11T08:22:33Z 2018-08-27 13:15:06 2018 book 27501 9783038970590 9783038970606 https://directory.doabooks.org/handle/20.500.12854/41140 eng image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International http://www.mdpi.com/books https://play.google.com/books https://doi.org/10.3390/books978-3-03897-060-6 MDPI - Multidisciplinary Digital Publishing Institute 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038970590 9783038970606 X, 290 open access |
| spellingShingle | QH301-705.5 riboswitch DNAzyme aptamer SELEX thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Andrew Brian Kinghorn (Ed.) Yee-Wai Cheung (Ed.) Julian Alexander Tanner (Ed.) Aptamers |
| title | Aptamers |
| title_full | Aptamers |
| title_fullStr | Aptamers |
| title_full_unstemmed | Aptamers |
| title_short | Aptamers |
| title_sort | aptamers |
| topic | QH301-705.5 riboswitch DNAzyme aptamer SELEX thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | QH301-705.5 riboswitch DNAzyme aptamer SELEX thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | 27501 |
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