AR Signaling in Human Malignancies: Prostate Cancer and Beyond
The notion that androgens and androgen receptor (AR) signaling are the hallmarks of prostate cancer oncogenesis and disease progression is generally well accepted. What is more poorly understood is the role of AR signaling in other human malignancies. This Special Issue of Cancers initially reviews...
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| Үндсэн зохиолч: | |
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| Формат: | Online |
| Хэл сонгох: | англи |
| Хэвлэсэн: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Нөхцлүүд: | |
| Онлайн хандалт: | 25387 |
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Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!
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| _version_ | 1869531428344037376 |
|---|---|
| author | Emmanuel S. Antonarakis (Ed.) |
| author_browse | Emmanuel S. Antonarakis (Ed.) |
| author_facet | Emmanuel S. Antonarakis (Ed.) |
| author_sort | Emmanuel S. Antonarakis (Ed.) |
| collection | Directory of Open Access Books |
| description | The notion that androgens and androgen receptor (AR) signaling are the hallmarks of prostate cancer oncogenesis and disease progression is generally well accepted. What is more poorly understood is the role of AR signaling in other human malignancies. This Special Issue of Cancers initially reviews the role of AR in advanced prostate cancer, and then explores the potential importance of AR signaling in other epithelial malignancies. The first few articles focus on the use of novel AR-targeting therapies in castration-resistant prostate cancer and the mechanisms of resistance to novel antiandrogens, and they also outline the interaction between AR and other cellular pathways, including PI3 kinase signaling, transcriptional regulation, angiogenesis, stromal factors, Wnt signaling, and epigenetic regulation in prostate cancer. The next several articles review the possible role of androgens and AR signaling in breast cancer, bladder cancer, salivary gland cancer, and hepatocellular carcinoma, as well as the potential treatment implications of using antiandrogen therapies in these non-prostatic malignancies. |
| format | Online |
| id | doab-20.500.12854ir-41149 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-411492024-03-31T13:10:21Z AR Signaling in Human Malignancies: Prostate Cancer and Beyond Emmanuel S. Antonarakis (Ed.) R5-920 prostate cancer pancreatic cancer salivary gland cancer ovarian cancer endometrial cancer breast cancer hepatocellular cancer AR signaling thema EDItEUR::M Medicine and Nursing The notion that androgens and androgen receptor (AR) signaling are the hallmarks of prostate cancer oncogenesis and disease progression is generally well accepted. What is more poorly understood is the role of AR signaling in other human malignancies. This Special Issue of Cancers initially reviews the role of AR in advanced prostate cancer, and then explores the potential importance of AR signaling in other epithelial malignancies. The first few articles focus on the use of novel AR-targeting therapies in castration-resistant prostate cancer and the mechanisms of resistance to novel antiandrogens, and they also outline the interaction between AR and other cellular pathways, including PI3 kinase signaling, transcriptional regulation, angiogenesis, stromal factors, Wnt signaling, and epigenetic regulation in prostate cancer. The next several articles review the possible role of androgens and AR signaling in breast cancer, bladder cancer, salivary gland cancer, and hepatocellular carcinoma, as well as the potential treatment implications of using antiandrogen therapies in these non-prostatic malignancies. 2021-02-11T08:22:50Z 2021-02-11T08:22:50Z 2018-02-16 08:45:39 2018 book 25387 9783038427407 9783038427391 https://directory.doabooks.org/handle/20.500.12854/41149 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International http://www.mdpi.com/books/pdfview/book/539 http://www.mdpi.com/books/pdfview/book/539 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03842-739-1 10.3390/books978-3-03842-739-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038427407 9783038427391 244 open access |
| spellingShingle | R5-920 prostate cancer pancreatic cancer salivary gland cancer ovarian cancer endometrial cancer breast cancer hepatocellular cancer AR signaling thema EDItEUR::M Medicine and Nursing Emmanuel S. Antonarakis (Ed.) AR Signaling in Human Malignancies: Prostate Cancer and Beyond |
| title | AR Signaling in Human Malignancies: Prostate Cancer and Beyond |
| title_full | AR Signaling in Human Malignancies: Prostate Cancer and Beyond |
| title_fullStr | AR Signaling in Human Malignancies: Prostate Cancer and Beyond |
| title_full_unstemmed | AR Signaling in Human Malignancies: Prostate Cancer and Beyond |
| title_short | AR Signaling in Human Malignancies: Prostate Cancer and Beyond |
| title_sort | ar signaling in human malignancies prostate cancer and beyond |
| topic | R5-920 prostate cancer pancreatic cancer salivary gland cancer ovarian cancer endometrial cancer breast cancer hepatocellular cancer AR signaling thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 prostate cancer pancreatic cancer salivary gland cancer ovarian cancer endometrial cancer breast cancer hepatocellular cancer AR signaling thema EDItEUR::M Medicine and Nursing |
| url | 25387 |
| work_keys_str_mv | AT emmanuelsantonarakised arsignalinginhumanmalignanciesprostatecancerandbeyond |