Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases?
Not only developed countries, but also most developing areas of the world, have experienced a surge in obesity prevalence over recent decades. Obesity complications are now among the leading causes of premature mortality, encompassing conditions such as coronary heart disease, stroke, and type 2 dia...
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| Egile Nagusiak: | , , , , |
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| Formatua: | Online |
| Hizkuntza: | ingelesa |
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Frontiers Media SA
2021
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| Gaiak: | |
| Sarrera elektronikoa: | 29654 |
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Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!
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| _version_ | 1869530630225657856 |
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| author | Robert K. Semple Sam Virtue Gilles Fromentin Patrick C. Even Nicholas M. Morton |
| author_browse | Gilles Fromentin Nicholas M. Morton Patrick C. Even Robert K. Semple Sam Virtue |
| author_facet | Robert K. Semple Sam Virtue Gilles Fromentin Patrick C. Even Nicholas M. Morton |
| author_sort | Robert K. Semple |
| collection | Directory of Open Access Books |
| description | Not only developed countries, but also most developing areas of the world, have experienced a surge in obesity prevalence over recent decades. Obesity complications are now among the leading causes of premature mortality, encompassing conditions such as coronary heart disease, stroke, and type 2 diabetes. This places a heavy burden on contemporary healthcare systems. While rodent models have limitations as experimental models of human obesity-related disease, study of rats and mice either spontaneously prone - or resistant - to obesity, or genetically engineered to illuminate underlying mechanisms has yielded key information about the metabolic defects linked to obesity, and their associated diseases. This topic includes both original research studies and reviews of the use of animal studies in specific areas of obesity-related disease. Various methodological approaches are discussed, with evaluation of the extent to which use of animal models has facilitated progress, or, conversely, has proved a cul de sac in investigation of human disease mechanisms. Consideration is also given to future strategies to use such rodent models optimally to enhance comprehension and treatment of pandemic human obesity-related diseases. |
| format | Online |
| id | doab-20.500.12854ir-41245 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-412452024-03-31T13:10:14Z Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases? Robert K. Semple Sam Virtue Gilles Fromentin Patrick C. Even Nicholas M. Morton R5-920 RC648-665 TX341-641 Obesity disease non-alcoholic fatty liver disease rodent models type 2 diabetes mellitus thema EDItEUR::M Medicine and Nursing Not only developed countries, but also most developing areas of the world, have experienced a surge in obesity prevalence over recent decades. Obesity complications are now among the leading causes of premature mortality, encompassing conditions such as coronary heart disease, stroke, and type 2 diabetes. This places a heavy burden on contemporary healthcare systems. While rodent models have limitations as experimental models of human obesity-related disease, study of rats and mice either spontaneously prone - or resistant - to obesity, or genetically engineered to illuminate underlying mechanisms has yielded key information about the metabolic defects linked to obesity, and their associated diseases. This topic includes both original research studies and reviews of the use of animal studies in specific areas of obesity-related disease. Various methodological approaches are discussed, with evaluation of the extent to which use of animal models has facilitated progress, or, conversely, has proved a cul de sac in investigation of human disease mechanisms. Consideration is also given to future strategies to use such rodent models optimally to enhance comprehension and treatment of pandemic human obesity-related diseases. 2021-02-11T08:26:45Z 2021-02-11T08:26:45Z 2018-11-16 17:17:57 2018 book 29654 16648714 9782889454259 https://directory.doabooks.org/handle/20.500.12854/41245 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/3368/are-rodent-models-fit-for-investigation-of-human-obesity-and-related-diseases Frontiers Media SA 10.3389/978-2-88945-425-9 10.3389/978-2-88945-425-9 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889454259 161 open access |
| spellingShingle | R5-920 RC648-665 TX341-641 Obesity disease non-alcoholic fatty liver disease rodent models type 2 diabetes mellitus thema EDItEUR::M Medicine and Nursing Robert K. Semple Sam Virtue Gilles Fromentin Patrick C. Even Nicholas M. Morton Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases? |
| title | Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases? |
| title_full | Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases? |
| title_fullStr | Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases? |
| title_full_unstemmed | Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases? |
| title_short | Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases? |
| title_sort | are rodent models fit for investigation of human obesity and related diseases |
| topic | R5-920 RC648-665 TX341-641 Obesity disease non-alcoholic fatty liver disease rodent models type 2 diabetes mellitus thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC648-665 TX341-641 Obesity disease non-alcoholic fatty liver disease rodent models type 2 diabetes mellitus thema EDItEUR::M Medicine and Nursing |
| url | 29654 |
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