Arrest chemokines
Arrest chemokines are a small group of chemokines that promote leukocyte arrest from rolling by triggering rapid integrin activation. Arrest chemokines have been described for neutrophils, monocytes, eosinophils, naïve lymphocytes and effector memory T cells. Most arrest chemokines are immobilized o...
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| Materyal Türü: | Online |
| Dil: | İngilizce |
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Frontiers Media SA
2021
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| Online Erişim: | 18185 |
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| _version_ | 1869527663163473920 |
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| author | Klaus Ley |
| author_browse | Klaus Ley |
| author_facet | Klaus Ley |
| author_sort | Klaus Ley |
| collection | Directory of Open Access Books |
| description | Arrest chemokines are a small group of chemokines that promote leukocyte arrest from rolling by triggering rapid integrin activation. Arrest chemokines have been described for neutrophils, monocytes, eosinophils, naïve lymphocytes and effector memory T cells. Most arrest chemokines are immobilized on the endothelial surface by binding to heparin sulfate proteoglycans. Whether soluble chemokines can promote integrin activation and arrest is controversial (Alon-Gerszten). Many aspects of the signaling pathway from the GPCR chemokine receptor to integrin activation are the subject of active investigation. Leukocyte adhesion deficiency III is a human disease in which chemokine-triggered integrin activation is defective because of a mutation in the cytoskeletal protein kindlin-3. About 10 different such mutations have been described. The defects seen in patients with LAD-III elucidate the importance of rapid integrin activation for host defense in humans. We welcome reports that help clarifying this crucial first step in the process of leukocyte transendothelial migration. |
| format | Online |
| id | doab-20.500.12854ir-41301 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-413012024-03-31T13:09:54Z Arrest chemokines Klaus Ley R5-920 RC581-607 chemokine LFA-1 Signal Transduction Talin integrin leukocyte adhesion VLA-4 Kindlin-3 thema EDItEUR::M Medicine and Nursing Arrest chemokines are a small group of chemokines that promote leukocyte arrest from rolling by triggering rapid integrin activation. Arrest chemokines have been described for neutrophils, monocytes, eosinophils, naïve lymphocytes and effector memory T cells. Most arrest chemokines are immobilized on the endothelial surface by binding to heparin sulfate proteoglycans. Whether soluble chemokines can promote integrin activation and arrest is controversial (Alon-Gerszten). Many aspects of the signaling pathway from the GPCR chemokine receptor to integrin activation are the subject of active investigation. Leukocyte adhesion deficiency III is a human disease in which chemokine-triggered integrin activation is defective because of a mutation in the cytoskeletal protein kindlin-3. About 10 different such mutations have been described. The defects seen in patients with LAD-III elucidate the importance of rapid integrin activation for host defense in humans. We welcome reports that help clarifying this crucial first step in the process of leukocyte transendothelial migration. 2021-02-11T08:29:31Z 2021-02-11T08:29:31Z 2016-01-19 14:05:46 2015 book 18185 16648714 9782889194308 https://directory.doabooks.org/handle/20.500.12854/41301 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Arrest_chemokines/546 http://journal.frontiersin.org/researchtopic/684/arrest-chemokines Frontiers Media SA 10.3389/978-2-88919-430-8 10.3389/978-2-88919-430-8 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889194308 108 open access |
| spellingShingle | R5-920 RC581-607 chemokine LFA-1 Signal Transduction Talin integrin leukocyte adhesion VLA-4 Kindlin-3 thema EDItEUR::M Medicine and Nursing Klaus Ley Arrest chemokines |
| title | Arrest chemokines |
| title_full | Arrest chemokines |
| title_fullStr | Arrest chemokines |
| title_full_unstemmed | Arrest chemokines |
| title_short | Arrest chemokines |
| title_sort | arrest chemokines |
| topic | R5-920 RC581-607 chemokine LFA-1 Signal Transduction Talin integrin leukocyte adhesion VLA-4 Kindlin-3 thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 chemokine LFA-1 Signal Transduction Talin integrin leukocyte adhesion VLA-4 Kindlin-3 thema EDItEUR::M Medicine and Nursing |
| url | 18185 |
| work_keys_str_mv | AT klausley arrestchemokines |