ATP-gated P2X receptors in Health and Disease
Extracellular ATP is currently recognized as one of the most widely distributed neurotransmitters and neuromodulators in the peripheral and central nervous system. ATP-gated P2X receptors are expressed by neurons, glial and many other non-neuronal cells and represent an attractive target for therape...
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| Format: | Online |
| Language: | English |
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Frontiers Media SA
2021
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| Online Access: | 17798 |
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| author | Geoffrey Burnstock Rashid Giniatullin Andrea Nistri Baljit S. Khakh |
| author_browse | Andrea Nistri Baljit S. Khakh Geoffrey Burnstock Rashid Giniatullin |
| author_facet | Geoffrey Burnstock Rashid Giniatullin Andrea Nistri Baljit S. Khakh |
| author_sort | Geoffrey Burnstock |
| collection | Directory of Open Access Books |
| description | Extracellular ATP is currently recognized as one of the most widely distributed neurotransmitters and neuromodulators in the peripheral and central nervous system. ATP-gated P2X receptors are expressed by neurons, glial and many other non-neuronal cells and represent an attractive target for therapeutic interventions. Diverse molecular and cellular mechanisms have been identified for P2X receptor functioning, including the ability to enlarge the size of the ion pore associated with the release of several key immune molecules. A major recent breakthrough was the determination of the X-ray crystal structures of zebrafish P2X4 receptor in ATP-bound and ATP-free states. The P2X receptor research field is rapidly growing, as evidenced by the almost 2000 papers published in the last 5 years. However, despite the fundamental signalling function of extracellular ATP in the nervous system, the widespread roles of P2X receptors have not been widely elucidated and presented in textbooks. In this volume of papers we aim to gather a collection of high quality papers, detailing the latest insights from the most accomplished international P2X receptor researchers. Importantly, basic research into P2X receptors has a strong translational impact and our collection of articles could be a valuable guide for the development of new pharmacological and biotechnological tools addressing the function of P2X receptors. Within this collection we plan to cover receptor structure-function relationships, receptors trafficking, to highlight the special properties of P2X receptors and their pharmacological profiles, and to describe the translational aspects of cellular ATP signaling in pain and in other neurological and vascular diseases. |
| format | Online |
| id | doab-20.500.12854ir-41518 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-415182024-04-05T17:29:57Z ATP-gated P2X receptors in Health and Disease Geoffrey Burnstock Rashid Giniatullin Andrea Nistri Baljit S. Khakh RC321-571 Q1-390 Central Nervous System Ion Channels neurotransmitters P2X receptor ATP thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Extracellular ATP is currently recognized as one of the most widely distributed neurotransmitters and neuromodulators in the peripheral and central nervous system. ATP-gated P2X receptors are expressed by neurons, glial and many other non-neuronal cells and represent an attractive target for therapeutic interventions. Diverse molecular and cellular mechanisms have been identified for P2X receptor functioning, including the ability to enlarge the size of the ion pore associated with the release of several key immune molecules. A major recent breakthrough was the determination of the X-ray crystal structures of zebrafish P2X4 receptor in ATP-bound and ATP-free states. The P2X receptor research field is rapidly growing, as evidenced by the almost 2000 papers published in the last 5 years. However, despite the fundamental signalling function of extracellular ATP in the nervous system, the widespread roles of P2X receptors have not been widely elucidated and presented in textbooks. In this volume of papers we aim to gather a collection of high quality papers, detailing the latest insights from the most accomplished international P2X receptor researchers. Importantly, basic research into P2X receptors has a strong translational impact and our collection of articles could be a valuable guide for the development of new pharmacological and biotechnological tools addressing the function of P2X receptors. Within this collection we plan to cover receptor structure-function relationships, receptors trafficking, to highlight the special properties of P2X receptors and their pharmacological profiles, and to describe the translational aspects of cellular ATP signaling in pain and in other neurological and vascular diseases. 2021-02-11T08:38:51Z 2021-02-11T08:38:51Z 2015-12-10 11:59:06 2015 book 17798 16648714 9782889194056 https://directory.doabooks.org/handle/20.500.12854/41518 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/ATP-gated_P2X_receptors_in_health_and_disease/404 http://journal.frontiersin.org/researchtopic/1642/atp-gated-p2x-receptors-in-health-and-disease Frontiers Media SA 10.3389/978-2-88919-405-6 10.3389/978-2-88919-405-6 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889194056 172 open access |
| spellingShingle | RC321-571 Q1-390 Central Nervous System Ion Channels neurotransmitters P2X receptor ATP thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Geoffrey Burnstock Rashid Giniatullin Andrea Nistri Baljit S. Khakh ATP-gated P2X receptors in Health and Disease |
| title | ATP-gated P2X receptors in Health and Disease |
| title_full | ATP-gated P2X receptors in Health and Disease |
| title_fullStr | ATP-gated P2X receptors in Health and Disease |
| title_full_unstemmed | ATP-gated P2X receptors in Health and Disease |
| title_short | ATP-gated P2X receptors in Health and Disease |
| title_sort | atp gated p2x receptors in health and disease |
| topic | RC321-571 Q1-390 Central Nervous System Ion Channels neurotransmitters P2X receptor ATP thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Central Nervous System Ion Channels neurotransmitters P2X receptor ATP thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 17798 |
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