Biofilm-Based Nosocomial Infections
Microbial biofilms have been implicated in a large number of acute and chronic infections, as well as in the failure of antibiotic treatment, particularly in hospitalized patients. In fact, the well-known persistence in the nosocomial environment of multidrug resistant microorganisms is believed to...
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| Format: | Online |
| Jezik: | engleski |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Online pristup: | 19032 |
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| _version_ | 1869524219314831360 |
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| author | Gianfranco Donelli (Ed.) |
| author_browse | Gianfranco Donelli (Ed.) |
| author_facet | Gianfranco Donelli (Ed.) |
| author_sort | Gianfranco Donelli (Ed.) |
| collection | Directory of Open Access Books |
| description | Microbial biofilms have been implicated in a large number of acute and chronic infections, as well as in the failure of antibiotic treatment, particularly in hospitalized patients. In fact, the well-known persistence in the nosocomial environment of multidrug resistant microorganisms is believed to be highly promoted by the ability of the great majority of the involved bacterial and fungal species to adhere on living or abiotic surfaces, and to grow in sessile mode, to form single- or multi-species biofilms. In these communities, microbes grow encased in a hydrated matrix of extracellular polymeric substances produced by themselves and are well protected from the host immune response and the attack of antimicrobial molecules. Thus, the establishment of microbial biofilm communities on the mucosal and soft tissues of hospitalized patients, as well as on the surfaces of indwelling devices and medical instruments, is expected to have a great influence on the success of the antibiotic therapies against most of the bugs involved in nosocomial infections, being biofilm-growing bacteria and fungi much less susceptible to antibiotics. |
| format | Online |
| id | doab-20.500.12854ir-42187 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-421872022-01-31T20:46:55Z Biofilm-Based Nosocomial Infections Gianfranco Donelli (Ed.) multidrug resistant microorganisms prostheses medical devices antibiotic resistance general hospitals long-term care settings medical instruments bacterial biofilms nosocomial Infections fungal biofilms healthcare-associated infections Microbial biofilms have been implicated in a large number of acute and chronic infections, as well as in the failure of antibiotic treatment, particularly in hospitalized patients. In fact, the well-known persistence in the nosocomial environment of multidrug resistant microorganisms is believed to be highly promoted by the ability of the great majority of the involved bacterial and fungal species to adhere on living or abiotic surfaces, and to grow in sessile mode, to form single- or multi-species biofilms. In these communities, microbes grow encased in a hydrated matrix of extracellular polymeric substances produced by themselves and are well protected from the host immune response and the attack of antimicrobial molecules. Thus, the establishment of microbial biofilm communities on the mucosal and soft tissues of hospitalized patients, as well as on the surfaces of indwelling devices and medical instruments, is expected to have a great influence on the success of the antibiotic therapies against most of the bugs involved in nosocomial infections, being biofilm-growing bacteria and fungi much less susceptible to antibiotics. 2021-02-11T09:08:05Z 2021-02-11T09:08:05Z 2016-05-12 12:14:31 2015 book 19032 9783038421351 9783038421368 https://directory.doabooks.org/handle/20.500.12854/42187 eng application/octet-stream Attribution 4.0 International http://www.mdpi.com/books/pdfview/book/175 http://www.mdpi.com/books/pdfview/book/175 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03842-136-8 10.3390/books978-3-03842-136-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038421351 9783038421368 238 open access |
| spellingShingle | multidrug resistant microorganisms prostheses medical devices antibiotic resistance general hospitals long-term care settings medical instruments bacterial biofilms nosocomial Infections fungal biofilms healthcare-associated infections Gianfranco Donelli (Ed.) Biofilm-Based Nosocomial Infections |
| title | Biofilm-Based Nosocomial Infections |
| title_full | Biofilm-Based Nosocomial Infections |
| title_fullStr | Biofilm-Based Nosocomial Infections |
| title_full_unstemmed | Biofilm-Based Nosocomial Infections |
| title_short | Biofilm-Based Nosocomial Infections |
| title_sort | biofilm based nosocomial infections |
| topic | multidrug resistant microorganisms prostheses medical devices antibiotic resistance general hospitals long-term care settings medical instruments bacterial biofilms nosocomial Infections fungal biofilms healthcare-associated infections |
| topic_facet | multidrug resistant microorganisms prostheses medical devices antibiotic resistance general hospitals long-term care settings medical instruments bacterial biofilms nosocomial Infections fungal biofilms healthcare-associated infections |
| url | 19032 |
| work_keys_str_mv | AT gianfrancodonellied biofilmbasednosocomialinfections |