Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges
The recent discovery of small and long non-coding RNAs (ncRNAs) has represented a major breakthrough in the life sciences. These molecules add a new layer of complexity to biological processes and pathways by revealing a sophisticated and dynamic interconnected system whose structure is just beginni...
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| 格式: | Online |
| 語言: | 英语 |
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Frontiers Media SA
2021
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| 主題: | |
| 在線閱讀: | 22947 |
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| _version_ | 1869519382050242560 |
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| author | Alessandro Lagana Alfredo Ferro Carlo Maria Croce |
| author_browse | Alessandro Lagana Alfredo Ferro Carlo Maria Croce |
| author_facet | Alessandro Lagana Alfredo Ferro Carlo Maria Croce |
| author_sort | Alessandro Lagana |
| collection | Directory of Open Access Books |
| description | The recent discovery of small and long non-coding RNAs (ncRNAs) has represented a major breakthrough in the life sciences. These molecules add a new layer of complexity to biological processes and pathways by revealing a sophisticated and dynamic interconnected system whose structure is just beginning to be uncovered. Genetic and epigenetic aberrations affecting ncRNA gene sequences and their expression have been linked to a variety of pathological conditions, including cancer, cardiovascular and neurological diseases. Latest advances in the development of high throughput analysis techniques may help to shed light on the complex regulatory mechanisms in which ncRNA molecules are involved. Bioinformatics tools constitute a unique and essential resource for non-coding RNA studies, providing a powerful technology to organize, integrate and analyze the huge amount of data produced daily by wet biology experiments in order to discover patterns, identify relationships among heterogeneous biological elements and formulate functional hypotheses. This Research Topic reviews current knowledge, introduces novel methods, and discusses open challenges of this exciting and innovative field in connection with the most important biomedical applications. It consists of four reviews and six original research and methods articles, spanning the full scope of the Research Topic. |
| format | Online |
| id | doab-20.500.12854ir-42212 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-422122024-04-11T15:10:45Z Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges Alessandro Lagana Alfredo Ferro Carlo Maria Croce TP248.13-248.65 TA1-2040 CRISPR CLIPseq RNA Editing bioinformatics isomiRs microRNA siRNA ncRNA networks RNAseq thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology The recent discovery of small and long non-coding RNAs (ncRNAs) has represented a major breakthrough in the life sciences. These molecules add a new layer of complexity to biological processes and pathways by revealing a sophisticated and dynamic interconnected system whose structure is just beginning to be uncovered. Genetic and epigenetic aberrations affecting ncRNA gene sequences and their expression have been linked to a variety of pathological conditions, including cancer, cardiovascular and neurological diseases. Latest advances in the development of high throughput analysis techniques may help to shed light on the complex regulatory mechanisms in which ncRNA molecules are involved. Bioinformatics tools constitute a unique and essential resource for non-coding RNA studies, providing a powerful technology to organize, integrate and analyze the huge amount of data produced daily by wet biology experiments in order to discover patterns, identify relationships among heterogeneous biological elements and formulate functional hypotheses. This Research Topic reviews current knowledge, introduces novel methods, and discusses open challenges of this exciting and innovative field in connection with the most important biomedical applications. It consists of four reviews and six original research and methods articles, spanning the full scope of the Research Topic. 2021-02-11T09:08:36Z 2021-02-11T09:08:36Z 2017-07-06 13:27:36 2017 book 22947 16648714 9782889450961 https://directory.doabooks.org/handle/20.500.12854/42212 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Bioinformatics_of_Non-Coding_RNAs_with_Applications_to_Biomedicine_Recent_Advances_and_Open_Challen/1110#nogo http://journal.frontiersin.org/researchtopic/2646/bioinformatics-of-non-coding-rnas-with-applications-to-biomedicine-recent-advances-and-open-challeng Frontiers Media SA 10.3389/978-2-88945-096-1 10.3389/978-2-88945-096-1 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889450961 95 open access |
| spellingShingle | TP248.13-248.65 TA1-2040 CRISPR CLIPseq RNA Editing bioinformatics isomiRs microRNA siRNA ncRNA networks RNAseq thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology Alessandro Lagana Alfredo Ferro Carlo Maria Croce Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges |
| title | Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges |
| title_full | Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges |
| title_fullStr | Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges |
| title_full_unstemmed | Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges |
| title_short | Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges |
| title_sort | bioinformatics of non coding rnas with applications to biomedicine recent advances and open challenges |
| topic | TP248.13-248.65 TA1-2040 CRISPR CLIPseq RNA Editing bioinformatics isomiRs microRNA siRNA ncRNA networks RNAseq thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology |
| topic_facet | TP248.13-248.65 TA1-2040 CRISPR CLIPseq RNA Editing bioinformatics isomiRs microRNA siRNA ncRNA networks RNAseq thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology |
| url | 22947 |
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