BK Channels: Integrators of Cellular Signals in Health and Disease
Maxi calcium-activated potassium channels (BK) are an amazing category of ion channels which are found in cellular plasma membranes as well as in membranes of intracellular organelles. The function of these channels is to repolarize any excited membrane by passing a potassium outward current, in res...
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| Format: | Online |
| Jezik: | engleski |
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Frontiers Media SA
2021
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| _version_ | 1869524628727136256 |
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| author | Alex Dopico Thomas M. Weiger Anton Hermann |
| author_browse | Alex Dopico Anton Hermann Thomas M. Weiger |
| author_facet | Alex Dopico Thomas M. Weiger Anton Hermann |
| author_sort | Alex Dopico |
| collection | Directory of Open Access Books |
| description | Maxi calcium-activated potassium channels (BK) are an amazing category of ion channels which are found in cellular plasma membranes as well as in membranes of intracellular organelles. The function of these channels is to repolarize any excited membrane by passing a potassium outward current, in response to depolarization and/or increase in local calcium levels. Thus, voltage and calcium ions are involved in gating the channel under physiological conditions. This dual activation makes them perfect sensors for many cellular events that require integration between intracellular calcium levels and electrical signals. A plethora of physiological and pathophysiological functions, such as membrane hyperpolarization, modulation of synaptic transmission, hormone secretion or mental deficiencies, vaso-regulation, epilepsies, heart diseases, myotonic dystrophies, hypertension etc, in almost all cells and tissues were reported for these channels. BK channels are main targets for important ligands like alcohol and gaseous neurotransmitters, such as NO, CO or H2S, to name a few. In the last years, the molecular entities and mechanisms involved in modulation of BK channels have gained tremendous attention, as the key role of these channels in cellular processes became increasingly recognized. Indeed, accessory proteins such as slob, beta and gamma subunits, all serve to modulate the channel gating characteristics. Moreover, channel subunit expression and function is further tuned by phosphorylation/ dephosphorylation processes, redox mechanisms and the lipid microenvironment of the BK channel protein complex. This e-book contains structural and functional aspects of BK channels, channel modulation by a variety of agents and cellular components, as well as the channel’s relevance in health and disease. |
| format | Online |
| id | doab-20.500.12854ir-42315 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-423152024-03-31T22:45:12Z BK Channels: Integrators of Cellular Signals in Health and Disease Alex Dopico Thomas M. Weiger Anton Hermann QP1-981 Q1-390 BK channel hydrogensulfide maxi calcium activated potassium channel disease nervous system Slo KCNMA1 health ethanol ischemia thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Maxi calcium-activated potassium channels (BK) are an amazing category of ion channels which are found in cellular plasma membranes as well as in membranes of intracellular organelles. The function of these channels is to repolarize any excited membrane by passing a potassium outward current, in response to depolarization and/or increase in local calcium levels. Thus, voltage and calcium ions are involved in gating the channel under physiological conditions. This dual activation makes them perfect sensors for many cellular events that require integration between intracellular calcium levels and electrical signals. A plethora of physiological and pathophysiological functions, such as membrane hyperpolarization, modulation of synaptic transmission, hormone secretion or mental deficiencies, vaso-regulation, epilepsies, heart diseases, myotonic dystrophies, hypertension etc, in almost all cells and tissues were reported for these channels. BK channels are main targets for important ligands like alcohol and gaseous neurotransmitters, such as NO, CO or H2S, to name a few. In the last years, the molecular entities and mechanisms involved in modulation of BK channels have gained tremendous attention, as the key role of these channels in cellular processes became increasingly recognized. Indeed, accessory proteins such as slob, beta and gamma subunits, all serve to modulate the channel gating characteristics. Moreover, channel subunit expression and function is further tuned by phosphorylation/ dephosphorylation processes, redox mechanisms and the lipid microenvironment of the BK channel protein complex. This e-book contains structural and functional aspects of BK channels, channel modulation by a variety of agents and cellular components, as well as the channel’s relevance in health and disease. 2021-02-11T09:12:39Z 2021-02-11T09:12:39Z 2018-02-27 16:16:44 2017 book 25600 16648714 9782889452910 https://directory.doabooks.org/handle/20.500.12854/42315 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/books/BK_Channels_Integrators_of_Cellular_Signals_in_Health_and_Disease/1373 https://www.frontiersin.org/research-topics/2413/bk-channels-integrators-of-cellular-signals-in-health-and-disease Frontiers Media SA 10.3389/978-2-88945-291-0 10.3389/978-2-88945-291-0 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889452910 183 open access |
| spellingShingle | QP1-981 Q1-390 BK channel hydrogensulfide maxi calcium activated potassium channel disease nervous system Slo KCNMA1 health ethanol ischemia thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Alex Dopico Thomas M. Weiger Anton Hermann BK Channels: Integrators of Cellular Signals in Health and Disease |
| title | BK Channels: Integrators of Cellular Signals in Health and Disease |
| title_full | BK Channels: Integrators of Cellular Signals in Health and Disease |
| title_fullStr | BK Channels: Integrators of Cellular Signals in Health and Disease |
| title_full_unstemmed | BK Channels: Integrators of Cellular Signals in Health and Disease |
| title_short | BK Channels: Integrators of Cellular Signals in Health and Disease |
| title_sort | bk channels integrators of cellular signals in health and disease |
| topic | QP1-981 Q1-390 BK channel hydrogensulfide maxi calcium activated potassium channel disease nervous system Slo KCNMA1 health ethanol ischemia thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| topic_facet | QP1-981 Q1-390 BK channel hydrogensulfide maxi calcium activated potassium channel disease nervous system Slo KCNMA1 health ethanol ischemia thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| url | 25600 |
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