Bone Marrow Adipose Tissue: Formation; Function; and Impact on Health and Disease
Adipocytes are a major component of the bone marrow, accounting for up to 70% of total bone marrow volume in healthy humans. Indeed, this bone marrow adipose tissue (often referred to as ‘MAT’ or ‘BMAT’) accounts for at least 5% of total adipose tissue mass in lean, healthy humans, suggesting a role...
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Frontiers Media SA
2021
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| On-line přístup: | 25559 |
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| author | Erica L. Scheller William P. Cawthorn |
| author_browse | Erica L. Scheller William P. Cawthorn |
| author_facet | Erica L. Scheller William P. Cawthorn |
| author_sort | Erica L. Scheller |
| collection | Directory of Open Access Books |
| description | Adipocytes are a major component of the bone marrow, accounting for up to 70% of total bone marrow volume in healthy humans. Indeed, this bone marrow adipose tissue (often referred to as ‘MAT’ or ‘BMAT’) accounts for at least 5% of total adipose tissue mass in lean, healthy humans, suggesting a role in normal physiology and development. Bone marrow adiposity further increases with ageing and in diverse clinical conditions, including major public health challenges such as osteoporosis. Yet despite this abundance and compelling clinical potential, bone marrow adipocytes have received surprisingly little attention from the biomedical research community. Thankfully, this is now beginning to change. Research over the past decade has begun to increase our knowledge of BMAT, including the conditions associated with altered bone marrow adiposity and the potential physiological and pathological functions of bone marrow adipocytes. The articles within this e-Book highlight many of these recent developments, underscoring our increasing knowledge of BMAT formation and function; showcasing emerging techniques for basic and clinical BMAT analysis; and highlighting key questions and future directions for this burgeoning and increasingly diverse field. The editors would like to express their thanks to the authors for contributing the articles within this e-Book; to the senior editors at Frontiers in Endocrinology for their guidance; and to the staff at Frontiers for their helpful input throughout. |
| format | Online |
| id | doab-20.500.12854ir-42361 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-423612024-03-30T23:22:44Z Bone Marrow Adipose Tissue: Formation; Function; and Impact on Health and Disease Erica L. Scheller William P. Cawthorn R5-920 RC648-665 bone thema EDItEUR::M Medicine and Nursing Adipocytes are a major component of the bone marrow, accounting for up to 70% of total bone marrow volume in healthy humans. Indeed, this bone marrow adipose tissue (often referred to as ‘MAT’ or ‘BMAT’) accounts for at least 5% of total adipose tissue mass in lean, healthy humans, suggesting a role in normal physiology and development. Bone marrow adiposity further increases with ageing and in diverse clinical conditions, including major public health challenges such as osteoporosis. Yet despite this abundance and compelling clinical potential, bone marrow adipocytes have received surprisingly little attention from the biomedical research community. Thankfully, this is now beginning to change. Research over the past decade has begun to increase our knowledge of BMAT, including the conditions associated with altered bone marrow adiposity and the potential physiological and pathological functions of bone marrow adipocytes. The articles within this e-Book highlight many of these recent developments, underscoring our increasing knowledge of BMAT formation and function; showcasing emerging techniques for basic and clinical BMAT analysis; and highlighting key questions and future directions for this burgeoning and increasingly diverse field. The editors would like to express their thanks to the authors for contributing the articles within this e-Book; to the senior editors at Frontiers in Endocrinology for their guidance; and to the staff at Frontiers for their helpful input throughout. 2021-02-11T09:14:13Z 2021-02-11T09:14:13Z 2018-02-27 16:16:44 2017 book 25559 16648714 9782889452453 https://directory.doabooks.org/handle/20.500.12854/42361 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Bone_Marrow_Adipose_Tissue_Formation_Function_and_Impact_on_Health_and_Disease/1287#nogo http://journal.frontiersin.org/researchtopic/4088/bone-marrow-adipose-tissue-formation-function-and-impact-on-health-and-disease Frontiers Media SA 10.3389/978-2-88945-245-3 10.3389/978-2-88945-245-3 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889452453 165 open access |
| spellingShingle | R5-920 RC648-665 bone thema EDItEUR::M Medicine and Nursing Erica L. Scheller William P. Cawthorn Bone Marrow Adipose Tissue: Formation; Function; and Impact on Health and Disease |
| title | Bone Marrow Adipose Tissue: Formation; Function; and Impact on Health and Disease |
| title_full | Bone Marrow Adipose Tissue: Formation; Function; and Impact on Health and Disease |
| title_fullStr | Bone Marrow Adipose Tissue: Formation; Function; and Impact on Health and Disease |
| title_full_unstemmed | Bone Marrow Adipose Tissue: Formation; Function; and Impact on Health and Disease |
| title_short | Bone Marrow Adipose Tissue: Formation; Function; and Impact on Health and Disease |
| title_sort | bone marrow adipose tissue formation function and impact on health and disease |
| topic | R5-920 RC648-665 bone thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC648-665 bone thema EDItEUR::M Medicine and Nursing |
| url | 25559 |
| work_keys_str_mv | AT ericalscheller bonemarrowadiposetissueformationfunctionandimpactonhealthanddisease AT williampcawthorn bonemarrowadiposetissueformationfunctionandimpactonhealthanddisease |