Brain Injury as a Neurodegenerative Disorder
It has been long assumed that following the resolution of acute injuries, traumatic brain injury represents a stable neural entity. However, there is growing evidence that a single moderate-severe brain injury may instead trigger an ongoing deteriorative process that commences sub-acutely, and occur...
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| Формат: | Online |
| Мова: | Англійська |
| Опубліковано: |
Frontiers Media SA
2021
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| Предмети: | |
| Онлайн доступ: | 18288 |
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| _version_ | 1869516394455891968 |
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| author | Robin E.A. Green |
| author_browse | Robin E.A. Green |
| author_facet | Robin E.A. Green |
| author_sort | Robin E.A. Green |
| collection | Directory of Open Access Books |
| description | It has been long assumed that following the resolution of acute injuries, traumatic brain injury represents a stable neural entity. However, there is growing evidence that a single moderate-severe brain injury may instead trigger an ongoing deteriorative process that commences sub-acutely, and occurs regardless of age. For scientists and clinicians, it is critical to examine this body of evidence and to explore its implications. Do the findings represent a neurodegenerative process or can they be alternatively explained? What are the neural, behavioural and functional characteristics of this progressive deterioration? Such information is needed to develop treatments to prevent or mitigate decline, and to inform the clinical care of brain injured patients. Research and clinical practice are influenced by the assumption that moderate-severe TBI is non-progressive, with few studies exploring treatments to prevent progression, and rehabilitation typically concentrated in the early stages of injury. Brain injuries can never be fully prevented. However, understanding that such progressive deterioration occurs opens a novel area of research - prevention of secondary decline - offering new possibilities for the improvement of long-term outcomes in people with traumatic brain injury. |
| format | Online |
| id | doab-20.500.12854ir-42415 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-424152024-04-05T12:35:37Z Brain Injury as a Neurodegenerative Disorder Robin E.A. Green RC321-571 Q1-390 Atrophy chronic TBI neurodegeneration moderate-severe TBI chronic traumatic encephalopathy thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences It has been long assumed that following the resolution of acute injuries, traumatic brain injury represents a stable neural entity. However, there is growing evidence that a single moderate-severe brain injury may instead trigger an ongoing deteriorative process that commences sub-acutely, and occurs regardless of age. For scientists and clinicians, it is critical to examine this body of evidence and to explore its implications. Do the findings represent a neurodegenerative process or can they be alternatively explained? What are the neural, behavioural and functional characteristics of this progressive deterioration? Such information is needed to develop treatments to prevent or mitigate decline, and to inform the clinical care of brain injured patients. Research and clinical practice are influenced by the assumption that moderate-severe TBI is non-progressive, with few studies exploring treatments to prevent progression, and rehabilitation typically concentrated in the early stages of injury. Brain injuries can never be fully prevented. However, understanding that such progressive deterioration occurs opens a novel area of research - prevention of secondary decline - offering new possibilities for the improvement of long-term outcomes in people with traumatic brain injury. 2021-02-11T09:16:47Z 2021-02-11T09:16:47Z 2016-01-19 14:05:46 2017 book 18288 16648714 9782889199013 https://directory.doabooks.org/handle/20.500.12854/42415 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Brain_Injury_as_a_Neurodegenerative_Disorder/1174 http://journal.frontiersin.org/researchtopic/304/brain-injury-as-a-neurodegenerative-disorder Frontiers Media SA 10.3389/978-2-88919-901-3 10.3389/978-2-88919-901-3 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889199013 102 open access |
| spellingShingle | RC321-571 Q1-390 Atrophy chronic TBI neurodegeneration moderate-severe TBI chronic traumatic encephalopathy thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Robin E.A. Green Brain Injury as a Neurodegenerative Disorder |
| title | Brain Injury as a Neurodegenerative Disorder |
| title_full | Brain Injury as a Neurodegenerative Disorder |
| title_fullStr | Brain Injury as a Neurodegenerative Disorder |
| title_full_unstemmed | Brain Injury as a Neurodegenerative Disorder |
| title_short | Brain Injury as a Neurodegenerative Disorder |
| title_sort | brain injury as a neurodegenerative disorder |
| topic | RC321-571 Q1-390 Atrophy chronic TBI neurodegeneration moderate-severe TBI chronic traumatic encephalopathy thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Atrophy chronic TBI neurodegeneration moderate-severe TBI chronic traumatic encephalopathy thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 18288 |
| work_keys_str_mv | AT robineagreen braininjuryasaneurodegenerativedisorder |