Ca2+ Signaling and Heart Rhythm
Ca2+ is a key second messenger in the intricate workings of the heart. In cardiac myocytes, Ca2+ signaling controls or modulates electrophysiological function, excitation-contraction coupling, contractile function, energy balance, cell death, and gene transcription. Thus, diverse Ca2+-dependent regu...
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| Автори: | , , , |
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| Формат: | Online |
| Мова: | Англійська |
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Frontiers Media SA
2021
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| Онлайн доступ: | 18261 |
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| _version_ | 1869520250959036416 |
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| author | Christopher L.-H. Huang Yunbo Ke R. John Solaro Ming Lei |
| author_browse | Christopher L.-H. Huang Ming Lei R. John Solaro Yunbo Ke |
| author_facet | Christopher L.-H. Huang Yunbo Ke R. John Solaro Ming Lei |
| author_sort | Christopher L.-H. Huang |
| collection | Directory of Open Access Books |
| description | Ca2+ is a key second messenger in the intricate workings of the heart. In cardiac myocytes, Ca2+ signaling controls or modulates electrophysiological function, excitation-contraction coupling, contractile function, energy balance, cell death, and gene transcription. Thus, diverse Ca2+-dependent regulatory processes occur simultaneously within a cell. Yet, distinct signals can be resolved by local Ca2+ sensitive protein complexes and differential Ca2+ signal integration. In addition to its importance to normal cardiac function, such regulation is also crucial in disease conditions. Ca2+ is likely involved in ectopic cardiac rhythms in both atrial and ventricular tissues through generating triggered activity often appearing as delayed afterdepolarisations, particularly following cellular Ca overloading. Recent studies also implicate Ca2+ in Na+ channel expression and properties with consequences for conduction velocity and therefore arrhythmic substrate. At the cellular level, such regulation involves control of the activity of membrane ion channels and Ca2+ handling proteins. These in turn involve multiple extra- and intracellular signaling pathways. This e-book assembles review and original articles from experts in this field. It summarises major recent progress bearing on roles of Ca2+ in cardiac electrophysiological function encompassing both normal and abnormal cardiac function. These extend from physiological roles of Ca2+ signaling in pacemaker function, in particular generation of sino-atrial pacemaker potentials, to pathological roles of abnormal Ca2+ signaling in both atrial and ventricular arrhythmogenesis. It also seeks to bridge the gap between advances in basic science and development of new therapies. |
| format | Online |
| id | doab-20.500.12854ir-42564 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-425642024-03-31T22:45:08Z Ca2+ Signaling and Heart Rhythm Christopher L.-H. Huang Yunbo Ke R. John Solaro Ming Lei QP1-981 Q1-390 Heart Pak1 SA node STIM1 TRPC Ca2+ Orai1 PP2A voltage gated Ca2+ channels thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Ca2+ is a key second messenger in the intricate workings of the heart. In cardiac myocytes, Ca2+ signaling controls or modulates electrophysiological function, excitation-contraction coupling, contractile function, energy balance, cell death, and gene transcription. Thus, diverse Ca2+-dependent regulatory processes occur simultaneously within a cell. Yet, distinct signals can be resolved by local Ca2+ sensitive protein complexes and differential Ca2+ signal integration. In addition to its importance to normal cardiac function, such regulation is also crucial in disease conditions. Ca2+ is likely involved in ectopic cardiac rhythms in both atrial and ventricular tissues through generating triggered activity often appearing as delayed afterdepolarisations, particularly following cellular Ca overloading. Recent studies also implicate Ca2+ in Na+ channel expression and properties with consequences for conduction velocity and therefore arrhythmic substrate. At the cellular level, such regulation involves control of the activity of membrane ion channels and Ca2+ handling proteins. These in turn involve multiple extra- and intracellular signaling pathways. This e-book assembles review and original articles from experts in this field. It summarises major recent progress bearing on roles of Ca2+ in cardiac electrophysiological function encompassing both normal and abnormal cardiac function. These extend from physiological roles of Ca2+ signaling in pacemaker function, in particular generation of sino-atrial pacemaker potentials, to pathological roles of abnormal Ca2+ signaling in both atrial and ventricular arrhythmogenesis. It also seeks to bridge the gap between advances in basic science and development of new therapies. 2021-02-11T09:23:24Z 2021-02-11T09:23:24Z 2016-01-19 14:05:46 2016 book 18261 16648714 9782889198740 https://directory.doabooks.org/handle/20.500.12854/42564 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Ca2_Signaling_and_Heart_Rhythm/931 http://journal.frontiersin.org/researchtopic/2578/ca2-signaling-and-heart-rhythm Frontiers Media SA 10.3389/978-2-88919-874-0 10.3389/978-2-88919-874-0 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889198740 133 open access |
| spellingShingle | QP1-981 Q1-390 Heart Pak1 SA node STIM1 TRPC Ca2+ Orai1 PP2A voltage gated Ca2+ channels thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Christopher L.-H. Huang Yunbo Ke R. John Solaro Ming Lei Ca2+ Signaling and Heart Rhythm |
| title | Ca2+ Signaling and Heart Rhythm |
| title_full | Ca2+ Signaling and Heart Rhythm |
| title_fullStr | Ca2+ Signaling and Heart Rhythm |
| title_full_unstemmed | Ca2+ Signaling and Heart Rhythm |
| title_short | Ca2+ Signaling and Heart Rhythm |
| title_sort | ca2 signaling and heart rhythm |
| topic | QP1-981 Q1-390 Heart Pak1 SA node STIM1 TRPC Ca2+ Orai1 PP2A voltage gated Ca2+ channels thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| topic_facet | QP1-981 Q1-390 Heart Pak1 SA node STIM1 TRPC Ca2+ Orai1 PP2A voltage gated Ca2+ channels thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| url | 18261 |
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