Cadmium Sources and Toxicity
Cadmium (Cd) is an environmental toxicant of continuing public health concern worldwide, because total diet studies have shown that Cd is present in virtually all foodstuffs. Consequently, foods that are frequently consumed in large quantities, such as rice, potatoes, wheat, leafy salad vegetables,...
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| Ձևաչափ: | Online |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Առցանց հասանելիություն: | 33675 |
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Չկան պիտակներ, Եղեք առաջինը, ով նշում է այս գրառումը!
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| _version_ | 1869520153429934080 |
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| author | Satarug, Soisungwan |
| author_browse | Satarug, Soisungwan |
| author_facet | Satarug, Soisungwan |
| author_sort | Satarug, Soisungwan |
| collection | Directory of Open Access Books |
| description | Cadmium (Cd) is an environmental toxicant of continuing public health concern worldwide, because total diet studies have shown that Cd is present in virtually all foodstuffs. Consequently, foods that are frequently consumed in large quantities, such as rice, potatoes, wheat, leafy salad vegetables, and other cereal crops, are the most significant dietary Cd sources. Moreover, Cd has chemical propensities that confer the potential to interfere with the physiological functions of calcium and zinc. Evidence of a wide range of diverse, toxic effects of Cd is increasingly apparent. In this collection, environmental Cd exposure is linked to an increased risk of chronic kidney disease that is known to be a cause of morbidity and mortality worldwide. Cd is also implicated in an early onset of menarche and deaths from cancer, especially in the uterus, kidney, and urinary tract. Moreover, Cd-induced kidney injury is replicated in Sprague Dawley rats, as is Cd-induced periodontal disease. Experimental studies suggest that the development of kidneys in fetuses and the function of insulin-producing cells may be adversely affected by Cd and that metformin, an anti-diabetic drug, is ineffective in Cd-intoxicated Wistar rats. |
| format | Online |
| id | doab-20.500.12854ir-42575 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-425752024-03-30T23:22:36Z Cadmium Sources and Toxicity Satarug, Soisungwan R5-920 RA1190-1270 microRNAs n/a embryonic kidneys exposure assessment image analysis periodontal disease menopause nephrotoxicity urine protein mitochondrial morphology female alveolar bone population health glomerular filtration rate threshold limit biomarkers toxicity threshold limit osteotoxicity intrauterine exposure metabolic syndrome dietary cadmium periodontitis cadmium toxicity metabolic disruptor cadmium urine cadmium chronic kidney disease N-acetyl-?-d-glucosaminidase estimated glomerular filtration rate one health clinical kidney function measure ?2-microglobulin cause of death follow-up study menarche HIF-1 bioenergetics sub-lethal exposure metformin toxicological mechanism tubular dysfunction mitochondrial network environmental pollution mortality body burden indicator cancer hypertension thema EDItEUR::M Medicine and Nursing Cadmium (Cd) is an environmental toxicant of continuing public health concern worldwide, because total diet studies have shown that Cd is present in virtually all foodstuffs. Consequently, foods that are frequently consumed in large quantities, such as rice, potatoes, wheat, leafy salad vegetables, and other cereal crops, are the most significant dietary Cd sources. Moreover, Cd has chemical propensities that confer the potential to interfere with the physiological functions of calcium and zinc. Evidence of a wide range of diverse, toxic effects of Cd is increasingly apparent. In this collection, environmental Cd exposure is linked to an increased risk of chronic kidney disease that is known to be a cause of morbidity and mortality worldwide. Cd is also implicated in an early onset of menarche and deaths from cancer, especially in the uterus, kidney, and urinary tract. Moreover, Cd-induced kidney injury is replicated in Sprague Dawley rats, as is Cd-induced periodontal disease. Experimental studies suggest that the development of kidneys in fetuses and the function of insulin-producing cells may be adversely affected by Cd and that metformin, an anti-diabetic drug, is ineffective in Cd-intoxicated Wistar rats. 2021-02-11T09:23:58Z 2021-02-11T09:23:58Z 2019-06-26 08:44:06 2019 book 33675 9783038979852 9783038979845 https://directory.doabooks.org/handle/20.500.12854/42575 eng image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/1336 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03897-985-2 10.3390/books978-3-03897-985-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038979852 9783038979845 130 open access |
| spellingShingle | R5-920 RA1190-1270 microRNAs n/a embryonic kidneys exposure assessment image analysis periodontal disease menopause nephrotoxicity urine protein mitochondrial morphology female alveolar bone population health glomerular filtration rate threshold limit biomarkers toxicity threshold limit osteotoxicity intrauterine exposure metabolic syndrome dietary cadmium periodontitis cadmium toxicity metabolic disruptor cadmium urine cadmium chronic kidney disease N-acetyl-?-d-glucosaminidase estimated glomerular filtration rate one health clinical kidney function measure ?2-microglobulin cause of death follow-up study menarche HIF-1 bioenergetics sub-lethal exposure metformin toxicological mechanism tubular dysfunction mitochondrial network environmental pollution mortality body burden indicator cancer hypertension thema EDItEUR::M Medicine and Nursing Satarug, Soisungwan Cadmium Sources and Toxicity |
| title | Cadmium Sources and Toxicity |
| title_full | Cadmium Sources and Toxicity |
| title_fullStr | Cadmium Sources and Toxicity |
| title_full_unstemmed | Cadmium Sources and Toxicity |
| title_short | Cadmium Sources and Toxicity |
| title_sort | cadmium sources and toxicity |
| topic | R5-920 RA1190-1270 microRNAs n/a embryonic kidneys exposure assessment image analysis periodontal disease menopause nephrotoxicity urine protein mitochondrial morphology female alveolar bone population health glomerular filtration rate threshold limit biomarkers toxicity threshold limit osteotoxicity intrauterine exposure metabolic syndrome dietary cadmium periodontitis cadmium toxicity metabolic disruptor cadmium urine cadmium chronic kidney disease N-acetyl-?-d-glucosaminidase estimated glomerular filtration rate one health clinical kidney function measure ?2-microglobulin cause of death follow-up study menarche HIF-1 bioenergetics sub-lethal exposure metformin toxicological mechanism tubular dysfunction mitochondrial network environmental pollution mortality body burden indicator cancer hypertension thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RA1190-1270 microRNAs n/a embryonic kidneys exposure assessment image analysis periodontal disease menopause nephrotoxicity urine protein mitochondrial morphology female alveolar bone population health glomerular filtration rate threshold limit biomarkers toxicity threshold limit osteotoxicity intrauterine exposure metabolic syndrome dietary cadmium periodontitis cadmium toxicity metabolic disruptor cadmium urine cadmium chronic kidney disease N-acetyl-?-d-glucosaminidase estimated glomerular filtration rate one health clinical kidney function measure ?2-microglobulin cause of death follow-up study menarche HIF-1 bioenergetics sub-lethal exposure metformin toxicological mechanism tubular dysfunction mitochondrial network environmental pollution mortality body burden indicator cancer hypertension thema EDItEUR::M Medicine and Nursing |
| url | 33675 |
| work_keys_str_mv | AT satarugsoisungwan cadmiumsourcesandtoxicity |