Cancer Biomarkers and Targets in Digestive Organs
Identification and development of cancer biomarkers and targets have greatly accelerated progress towards precision medicine in oncology. Studies of tumor biology have not only provided insights into the mechanisms underlying carcinogenesis, but also led to discovery of molecules that have been deve...
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| Format: | Online |
| Language: | English |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Online Access: | 42510 |
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| _version_ | 1869522031798648832 |
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| author | Lee, Nikki Yee, Nelson |
| author_browse | Lee, Nikki Yee, Nelson |
| author_facet | Lee, Nikki Yee, Nelson |
| author_sort | Lee, Nikki |
| collection | Directory of Open Access Books |
| description | Identification and development of cancer biomarkers and targets have greatly accelerated progress towards precision medicine in oncology. Studies of tumor biology have not only provided insights into the mechanisms underlying carcinogenesis, but also led to discovery of molecules that have been developed into cancer biomarkers and targets. Multi-platforms for molecular characterization of tumors using next-generation genomic sequencing, immunohistochemistry, in situ hybridization, and blood-based biopsies have greatly expanded the portfolio of potential biomarkers and targets. These cancer biomarkers have been developed for diagnosis, early detection, prognosis, and prediction of treatment response. The molecular targets have been exploited for anti-cancer therapy and delivery of therapeutic agents. This Special Issue of Biomedicines focuses on recent advances in the discovery, characterization, translation, and clinical application of cancer biomarkers and targets in malignant diseases of the digestive system. The goal is to stimulate basic and translational research and clinical collaboration in this exciting field with the hope of developing strategies for prevention and early detection/diagnosis of cancer in digestive organs, and improving therapeutic and psychosocial outcomes in patients with these malignant diseases. |
| format | Online |
| id | doab-20.500.12854ir-42637 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-426372024-03-30T23:22:57Z Cancer Biomarkers and Targets in Digestive Organs Lee, Nikki Yee, Nelson R5-920 n/a liver graft injury HFE neurokinin chemotherapy intestinal tumors therapeutic targets biliary tract carcinoma hepatocellular carcinoma clinical trial cell adhesion molecules colorectal cancer biomarkers phenotypic mosaics gastrointestinal oncology Asian Cancer Research Group (ACRG) biomarker psychosocial support precision therapy pancreatic carcinoma precision medicine Liver transplantation predictive biomarkers CD274 cholecystokinin The Cancer Genome Atlas (TCGA) gastrin pembrolizumab immunotherapy gastrin-releasing peptide stereotactic body radiation therapy immunohistochemistry gastric carcinoma liver transplant CAM invasion assay intragraft gene expression profiles molecular profiling targeted therapy neurotensin intestinal disorder ramucirumab next-generation sequencing colorectal carcinoma tumor progenitor circulating tumor cells gastrointestinal malignancies bombesin trastuzumab somatostatin zebrafish G protein–coupled receptors thema EDItEUR::M Medicine and Nursing Identification and development of cancer biomarkers and targets have greatly accelerated progress towards precision medicine in oncology. Studies of tumor biology have not only provided insights into the mechanisms underlying carcinogenesis, but also led to discovery of molecules that have been developed into cancer biomarkers and targets. Multi-platforms for molecular characterization of tumors using next-generation genomic sequencing, immunohistochemistry, in situ hybridization, and blood-based biopsies have greatly expanded the portfolio of potential biomarkers and targets. These cancer biomarkers have been developed for diagnosis, early detection, prognosis, and prediction of treatment response. The molecular targets have been exploited for anti-cancer therapy and delivery of therapeutic agents. This Special Issue of Biomedicines focuses on recent advances in the discovery, characterization, translation, and clinical application of cancer biomarkers and targets in malignant diseases of the digestive system. The goal is to stimulate basic and translational research and clinical collaboration in this exciting field with the hope of developing strategies for prevention and early detection/diagnosis of cancer in digestive organs, and improving therapeutic and psychosocial outcomes in patients with these malignant diseases. 2021-02-11T09:28:03Z 2021-02-11T09:28:03Z 2019-12-09 11:49:15 2019 book 42510 9783039214648 9783039214631 https://directory.doabooks.org/handle/20.500.12854/42637 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/1534 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03921-464-8 10.3390/books978-3-03921-464-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039214648 9783039214631 146 open access |
| spellingShingle | R5-920 n/a liver graft injury HFE neurokinin chemotherapy intestinal tumors therapeutic targets biliary tract carcinoma hepatocellular carcinoma clinical trial cell adhesion molecules colorectal cancer biomarkers phenotypic mosaics gastrointestinal oncology Asian Cancer Research Group (ACRG) biomarker psychosocial support precision therapy pancreatic carcinoma precision medicine Liver transplantation predictive biomarkers CD274 cholecystokinin The Cancer Genome Atlas (TCGA) gastrin pembrolizumab immunotherapy gastrin-releasing peptide stereotactic body radiation therapy immunohistochemistry gastric carcinoma liver transplant CAM invasion assay intragraft gene expression profiles molecular profiling targeted therapy neurotensin intestinal disorder ramucirumab next-generation sequencing colorectal carcinoma tumor progenitor circulating tumor cells gastrointestinal malignancies bombesin trastuzumab somatostatin zebrafish G protein–coupled receptors thema EDItEUR::M Medicine and Nursing Lee, Nikki Yee, Nelson Cancer Biomarkers and Targets in Digestive Organs |
| title | Cancer Biomarkers and Targets in Digestive Organs |
| title_full | Cancer Biomarkers and Targets in Digestive Organs |
| title_fullStr | Cancer Biomarkers and Targets in Digestive Organs |
| title_full_unstemmed | Cancer Biomarkers and Targets in Digestive Organs |
| title_short | Cancer Biomarkers and Targets in Digestive Organs |
| title_sort | cancer biomarkers and targets in digestive organs |
| topic | R5-920 n/a liver graft injury HFE neurokinin chemotherapy intestinal tumors therapeutic targets biliary tract carcinoma hepatocellular carcinoma clinical trial cell adhesion molecules colorectal cancer biomarkers phenotypic mosaics gastrointestinal oncology Asian Cancer Research Group (ACRG) biomarker psychosocial support precision therapy pancreatic carcinoma precision medicine Liver transplantation predictive biomarkers CD274 cholecystokinin The Cancer Genome Atlas (TCGA) gastrin pembrolizumab immunotherapy gastrin-releasing peptide stereotactic body radiation therapy immunohistochemistry gastric carcinoma liver transplant CAM invasion assay intragraft gene expression profiles molecular profiling targeted therapy neurotensin intestinal disorder ramucirumab next-generation sequencing colorectal carcinoma tumor progenitor circulating tumor cells gastrointestinal malignancies bombesin trastuzumab somatostatin zebrafish G protein–coupled receptors thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 n/a liver graft injury HFE neurokinin chemotherapy intestinal tumors therapeutic targets biliary tract carcinoma hepatocellular carcinoma clinical trial cell adhesion molecules colorectal cancer biomarkers phenotypic mosaics gastrointestinal oncology Asian Cancer Research Group (ACRG) biomarker psychosocial support precision therapy pancreatic carcinoma precision medicine Liver transplantation predictive biomarkers CD274 cholecystokinin The Cancer Genome Atlas (TCGA) gastrin pembrolizumab immunotherapy gastrin-releasing peptide stereotactic body radiation therapy immunohistochemistry gastric carcinoma liver transplant CAM invasion assay intragraft gene expression profiles molecular profiling targeted therapy neurotensin intestinal disorder ramucirumab next-generation sequencing colorectal carcinoma tumor progenitor circulating tumor cells gastrointestinal malignancies bombesin trastuzumab somatostatin zebrafish G protein–coupled receptors thema EDItEUR::M Medicine and Nursing |
| url | 42510 |
| work_keys_str_mv | AT leenikki cancerbiomarkersandtargetsindigestiveorgans AT yeenelson cancerbiomarkersandtargetsindigestiveorgans |