Cancer Immunotherapy & Immuno-monitoring: Mechanism, Treatment, Diagnosis, and Emerging Tools
In the past decade, significant progresses have taken place in the field of cancer immunotherapy. Tumor-targeting immunotherapies are being developed for most human cancers, including melanoma, prostate cancer, glioblastoma, sarcoma, lung carcinoma and hepatocellular carcinoma. The FDA has approved...
Saved in:
| Main Authors: | , , |
|---|---|
| 格式: | Online |
| 語言: | 英语 |
| 出版: |
Frontiers Media SA
2021
|
| 主題: | |
| 在線閱讀: | 17750 |
| 標簽: |
沒有標簽, 成為第一個標記此記錄!
|
| _version_ | 1869522060900827136 |
|---|---|
| author | Chao Ma Antoni Ribas Rong Fan |
| author_browse | Antoni Ribas Chao Ma Rong Fan |
| author_facet | Chao Ma Antoni Ribas Rong Fan |
| author_sort | Chao Ma |
| collection | Directory of Open Access Books |
| description | In the past decade, significant progresses have taken place in the field of cancer immunotherapy. Tumor-targeting immunotherapies are being developed for most human cancers, including melanoma, prostate cancer, glioblastoma, sarcoma, lung carcinoma and hepatocellular carcinoma. The FDA has approved multiple molecular immunotherapeutics, such as Ipilimumab; cellular immunotherapies (e.g. adoptive cell transfer) are being tested in phase II/III clinical trials. Immunotherapetics has evolved into a sophisticated field: Multimodal therapeutic regimens are administrated to induce focused responses, curtail side- effects and improve therapeutic efficacy. The lack of effective clinical assessment tools remains a major challenge. Because of the intricacy of antitumor response, it is essential to scrutinize individual tumor-targeting immune cells and their functions at the finest details - molecules. In this regard, flow cytometry analysis modernized hematology and allows characterization of surface molecular signature on individual cells. More recently, microchip technologies and new variations of cytometry have enormously expanded the spectrum, throughout and multiplexity of single cell analysis. Nowadays, tens of millions of readouts can be generated through the course of a cancer immunotherapy to monitor the abundance, phenotype and a myriad of effector functions of single immune cells. At the same time, big data analytics and data mining methodologies have been adapted to achieve sensible diagnostic interpretations. Such a marriage of technology and analytics opens the door for informative point-of-care assessment of therapeutic efficacy and ensures timely therapeutic decisions. The new generation of personalized clinical diagnostics will revolutionize healthcare in the years to come. |
| format | Online |
| id | doab-20.500.12854ir-42640 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-426402024-03-30T23:22:58Z Cancer Immunotherapy & Immuno-monitoring: Mechanism, Treatment, Diagnosis, and Emerging Tools Chao Ma Antoni Ribas Rong Fan R5-920 RC254-282 immune assessment single cell analysis cancer immunotherapy tumor immunity immune suppression thema EDItEUR::M Medicine and Nursing In the past decade, significant progresses have taken place in the field of cancer immunotherapy. Tumor-targeting immunotherapies are being developed for most human cancers, including melanoma, prostate cancer, glioblastoma, sarcoma, lung carcinoma and hepatocellular carcinoma. The FDA has approved multiple molecular immunotherapeutics, such as Ipilimumab; cellular immunotherapies (e.g. adoptive cell transfer) are being tested in phase II/III clinical trials. Immunotherapetics has evolved into a sophisticated field: Multimodal therapeutic regimens are administrated to induce focused responses, curtail side- effects and improve therapeutic efficacy. The lack of effective clinical assessment tools remains a major challenge. Because of the intricacy of antitumor response, it is essential to scrutinize individual tumor-targeting immune cells and their functions at the finest details - molecules. In this regard, flow cytometry analysis modernized hematology and allows characterization of surface molecular signature on individual cells. More recently, microchip technologies and new variations of cytometry have enormously expanded the spectrum, throughout and multiplexity of single cell analysis. Nowadays, tens of millions of readouts can be generated through the course of a cancer immunotherapy to monitor the abundance, phenotype and a myriad of effector functions of single immune cells. At the same time, big data analytics and data mining methodologies have been adapted to achieve sensible diagnostic interpretations. Such a marriage of technology and analytics opens the door for informative point-of-care assessment of therapeutic efficacy and ensures timely therapeutic decisions. The new generation of personalized clinical diagnostics will revolutionize healthcare in the years to come. 2021-02-11T09:28:09Z 2021-02-11T09:28:09Z 2015-12-03 13:02:24 2014 book 17750 16648714 9782889193806 https://directory.doabooks.org/handle/20.500.12854/42640 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Cancer_Immunotherapy__Immuno-monitoring_Mechanism_Treatment_Diagnosis_and_Emerging_Tools/394 http://journal.frontiersin.org/researchtopic/834/cancer-immunotherapy-immuno-monitoring-mechanism-treatment-diagnosis-and-emerging-tools Frontiers Media SA 10.3389/978-2-88919-380-6 10.3389/978-2-88919-380-6 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889193806 97 open access |
| spellingShingle | R5-920 RC254-282 immune assessment single cell analysis cancer immunotherapy tumor immunity immune suppression thema EDItEUR::M Medicine and Nursing Chao Ma Antoni Ribas Rong Fan Cancer Immunotherapy & Immuno-monitoring: Mechanism, Treatment, Diagnosis, and Emerging Tools |
| title | Cancer Immunotherapy & Immuno-monitoring: Mechanism, Treatment, Diagnosis, and Emerging Tools |
| title_full | Cancer Immunotherapy & Immuno-monitoring: Mechanism, Treatment, Diagnosis, and Emerging Tools |
| title_fullStr | Cancer Immunotherapy & Immuno-monitoring: Mechanism, Treatment, Diagnosis, and Emerging Tools |
| title_full_unstemmed | Cancer Immunotherapy & Immuno-monitoring: Mechanism, Treatment, Diagnosis, and Emerging Tools |
| title_short | Cancer Immunotherapy & Immuno-monitoring: Mechanism, Treatment, Diagnosis, and Emerging Tools |
| title_sort | cancer immunotherapy immuno monitoring mechanism treatment diagnosis and emerging tools |
| topic | R5-920 RC254-282 immune assessment single cell analysis cancer immunotherapy tumor immunity immune suppression thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC254-282 immune assessment single cell analysis cancer immunotherapy tumor immunity immune suppression thema EDItEUR::M Medicine and Nursing |
| url | 17750 |
| work_keys_str_mv | AT chaoma cancerimmunotherapyimmunomonitoringmechanismtreatmentdiagnosisandemergingtools AT antoniribas cancerimmunotherapyimmunomonitoringmechanismtreatmentdiagnosisandemergingtools AT rongfan cancerimmunotherapyimmunomonitoringmechanismtreatmentdiagnosisandemergingtools |