Cancer Metabolism: Molecular Targeting and Implications for Therapy
Development of an effective anticancer therapeutic necessitates the selection of cancer-related or cancer-specific pathways or molecules that are sensitive to intervention. Several such critical yet sensitive molecular targets have been recognized, and their specific antagonists or inhibitors valida...
Đã lưu trong:
| Tác giả chính: | |
|---|---|
| Định dạng: | Online |
| Ngôn ngữ: | Tiếng Anh |
| Được phát hành: |
Frontiers Media SA
2021
|
| Những chủ đề: | |
| Truy cập trực tuyến: | 25625 |
| Các nhãn: |
Không có thẻ, Là người đầu tiên thẻ bản ghi này!
|
| _version_ | 1869523611559133184 |
|---|---|
| author | Shanmugasundaram Ganapathy-Kanniappan |
| author_browse | Shanmugasundaram Ganapathy-Kanniappan |
| author_facet | Shanmugasundaram Ganapathy-Kanniappan |
| author_sort | Shanmugasundaram Ganapathy-Kanniappan |
| collection | Directory of Open Access Books |
| description | Development of an effective anticancer therapeutic necessitates the selection of cancer-related or cancer-specific pathways or molecules that are sensitive to intervention. Several such critical yet sensitive molecular targets have been recognized, and their specific antagonists or inhibitors validated as potential therapeutics in preclinical models. Yet, majority of anticancer principles or therapeutics show limited success in the clinical translation. Thus, the need for the development of an effective therapeutic strategy persists. “Altered energy metabolism” in cancer is one of the earliest known biochemical phenotypes which dates back to the early 20th century. The German scientist, Otto Warburg and his team (Warburg, Wind, Negelein 1926; Warburg, Wind, Negelein 1927) provided the first evidence that the glucose metabolism of cancer cells diverge from normal cells. This phenomenal discovery on deregulated glucose metabolism or cellular bioenergetics is frequently witnessed in majority of solid malignancies. Currently, the altered glucose metabolism is used in the clinical diagnosis of cancer through positron emission tomography (PET) imaging. Thus, the “deregulated bioenergetics” is a clinically relevant metabolic signature of cancer cells, hence recognized as one of the hallmarks of cancer (Hanahan and Weinberg 2011). Accumulating data unequivocally demonstrate that, besides cellular bioenergetics, cancer metabolism facilitates several cancer-related processes including metastasis, therapeutic resistance and so on. Recent reports also demonstrate the oncogenic regulation of glucose metabolism (e.g. glycolysis) indicating a functional link between neoplastic growth and cancer metabolism. Thus, cancer metabolism, which is already exploited in cancer diagnosis, remains an attractive target for therapeutic intervention as well. The Frontiers in Oncology Research Topic “Cancer Metabolism: Molecular Targeting and Implications for Therapy” emphases on recent advances in our understanding of metabolic reprogramming in cancer, and the recognition of key molecules for therapeutic targeting. Besides, the topic also deliberates the implications of metabolic targeting beyond the energy metabolism of cancer. The research topic integrates a series of reviews, mini-reviews and original research articles to share current perspectives on cancer metabolism, and to stimulate an open forum to discuss potential challenges and future directions of research necessary to develop effective anticancer strategies. |
| format | Online |
| id | doab-20.500.12854ir-42642 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-426422024-03-31T13:09:51Z Cancer Metabolism: Molecular Targeting and Implications for Therapy Shanmugasundaram Ganapathy-Kanniappan R5-920 RC254-282 Tumor microenvironment metastasis Cancer Metabolism glycolysis immunotherapy epigenetic regulation metabolic reprogramming Warburg effect thema EDItEUR::M Medicine and Nursing Development of an effective anticancer therapeutic necessitates the selection of cancer-related or cancer-specific pathways or molecules that are sensitive to intervention. Several such critical yet sensitive molecular targets have been recognized, and their specific antagonists or inhibitors validated as potential therapeutics in preclinical models. Yet, majority of anticancer principles or therapeutics show limited success in the clinical translation. Thus, the need for the development of an effective therapeutic strategy persists. “Altered energy metabolism” in cancer is one of the earliest known biochemical phenotypes which dates back to the early 20th century. The German scientist, Otto Warburg and his team (Warburg, Wind, Negelein 1926; Warburg, Wind, Negelein 1927) provided the first evidence that the glucose metabolism of cancer cells diverge from normal cells. This phenomenal discovery on deregulated glucose metabolism or cellular bioenergetics is frequently witnessed in majority of solid malignancies. Currently, the altered glucose metabolism is used in the clinical diagnosis of cancer through positron emission tomography (PET) imaging. Thus, the “deregulated bioenergetics” is a clinically relevant metabolic signature of cancer cells, hence recognized as one of the hallmarks of cancer (Hanahan and Weinberg 2011). Accumulating data unequivocally demonstrate that, besides cellular bioenergetics, cancer metabolism facilitates several cancer-related processes including metastasis, therapeutic resistance and so on. Recent reports also demonstrate the oncogenic regulation of glucose metabolism (e.g. glycolysis) indicating a functional link between neoplastic growth and cancer metabolism. Thus, cancer metabolism, which is already exploited in cancer diagnosis, remains an attractive target for therapeutic intervention as well. The Frontiers in Oncology Research Topic “Cancer Metabolism: Molecular Targeting and Implications for Therapy” emphases on recent advances in our understanding of metabolic reprogramming in cancer, and the recognition of key molecules for therapeutic targeting. Besides, the topic also deliberates the implications of metabolic targeting beyond the energy metabolism of cancer. The research topic integrates a series of reviews, mini-reviews and original research articles to share current perspectives on cancer metabolism, and to stimulate an open forum to discuss potential challenges and future directions of research necessary to develop effective anticancer strategies. 2021-02-11T09:28:12Z 2021-02-11T09:28:12Z 2018-02-27 16:16:45 2017 book 25625 16648714 9782889453221 https://directory.doabooks.org/handle/20.500.12854/42642 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/books/Cancer_Metabolism_Molecular_Targeting_and_Implications_for_Therapy/1367#nogo https://www.frontiersin.org/research-topics/4754/cancer-metabolism-molecular-targeting-and-implications-for-therapy Frontiers Media SA 10.3389/978-2-88945-322-1 10.3389/978-2-88945-322-1 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889453221 114 open access |
| spellingShingle | R5-920 RC254-282 Tumor microenvironment metastasis Cancer Metabolism glycolysis immunotherapy epigenetic regulation metabolic reprogramming Warburg effect thema EDItEUR::M Medicine and Nursing Shanmugasundaram Ganapathy-Kanniappan Cancer Metabolism: Molecular Targeting and Implications for Therapy |
| title | Cancer Metabolism: Molecular Targeting and Implications for Therapy |
| title_full | Cancer Metabolism: Molecular Targeting and Implications for Therapy |
| title_fullStr | Cancer Metabolism: Molecular Targeting and Implications for Therapy |
| title_full_unstemmed | Cancer Metabolism: Molecular Targeting and Implications for Therapy |
| title_short | Cancer Metabolism: Molecular Targeting and Implications for Therapy |
| title_sort | cancer metabolism molecular targeting and implications for therapy |
| topic | R5-920 RC254-282 Tumor microenvironment metastasis Cancer Metabolism glycolysis immunotherapy epigenetic regulation metabolic reprogramming Warburg effect thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC254-282 Tumor microenvironment metastasis Cancer Metabolism glycolysis immunotherapy epigenetic regulation metabolic reprogramming Warburg effect thema EDItEUR::M Medicine and Nursing |
| url | 25625 |
| work_keys_str_mv | AT shanmugasundaramganapathykanniappan cancermetabolismmoleculartargetingandimplicationsfortherapy |