Cancer Nanotheranostics: What Have We Learned So Far?
After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for m...
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| פורמט: | Online |
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Frontiers Media SA
2021
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| גישה מקוונת: | 18894 |
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| _version_ | 1869514990704132096 |
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| author | Pedro Viana Baptista Jesus M. De La Fuente Joao Conde Furong Tian |
| author_browse | Furong Tian Jesus M. De La Fuente Joao Conde Pedro Viana Baptista |
| author_facet | Pedro Viana Baptista Jesus M. De La Fuente Joao Conde Furong Tian |
| author_sort | Pedro Viana Baptista |
| collection | Directory of Open Access Books |
| description | After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely. It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer. In fact, the National Cancer Institute predicts that over the next years, nanotechnology will result in important advances in early detection, molecular imaging, targeted and multifunctional therapeutics, prevention and control of cancer. Nanotechnology offers numerous tools to diagnose and treat cancer, such as new imaging agents, multifunctional devices capable of overcome biological barriers to deliver therapeutic agents directly to cells and tissues involved in cancer growth and metastasis, and devices capable of predicting molecular changes to prevent action against precancerous cells. Nanomaterials-based delivery systems in Theranostics (Diagnostics & Therapy) provide better penetration of therapeutic and diagnostic substances within the body at a reduced risk in comparison to conventional therapies. At the present time, there is a growing need to enhance the capability of theranostics procedures where nanomaterials-based sensors may provide for the simultaneous detection of several gene-associated conditions and nanodevices with the ability to monitor real-time drug action. These innovative multifunctional nanocarriers for cancer theranostics may allow the development of diagnostics systems such as colorimetric and immunoassays, and in therapy approaches through gene therapy, drug delivery and tumor targeting systems in cancer. Some of the thousands and thousands of published nanosystems so far will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their integration in future diagnostics platforms. Nevertheless, despite the significant efforts towards the use of nanomaterials in biologically relevant research, more in vivo studies are needed to assess the applicability of these materials as delivery agents. In fact, only a few went through feasible clinical trials. Nanomaterials have to serve as the norm rather than an exception in the future conventional cancer treatments. Future in vivo work will need to carefully consider the correct choice of chemical modifications to incorporate into the multifunctional nanocarriers to avoid activation off-target, side effects and toxicity. Moreover the majority of studies on nanomaterials do not consider the final application to guide the design of nanomaterial. Instead, the focus is predominantly on engineering materials with specific physical or chemical properties. It is imperative to learn how advances in nanosystem’s capabilities are being used to identify new diagnostic and therapy tools driving the development of personalized medicine in oncology; discover how integrating cancer research and nanotechnology modeling can help patient diagnosis and treatment; recognize how to translate nanotheranostics data into an actionable clinical strategy; discuss with industry leaders how nanotheranostics is evolving and what the impact is on current research efforts; and last but not least, learn what approaches are proving fruitful in turning promising clinical data into treatment realities. |
| format | Online |
| id | doab-20.500.12854ir-42645 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-426452024-04-05T12:38:45Z Cancer Nanotheranostics: What Have We Learned So Far? Pedro Viana Baptista Jesus M. De La Fuente Joao Conde Furong Tian QD1-999 Q1-390 Nanoparticles Gene Therapy Immunotherapy bioimaging theranostics nanomaterials Drug delivery Nanomedicine Cancer Phototherapy thema EDItEUR::P Mathematics and Science::PN Chemistry After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely. It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer. In fact, the National Cancer Institute predicts that over the next years, nanotechnology will result in important advances in early detection, molecular imaging, targeted and multifunctional therapeutics, prevention and control of cancer. Nanotechnology offers numerous tools to diagnose and treat cancer, such as new imaging agents, multifunctional devices capable of overcome biological barriers to deliver therapeutic agents directly to cells and tissues involved in cancer growth and metastasis, and devices capable of predicting molecular changes to prevent action against precancerous cells. Nanomaterials-based delivery systems in Theranostics (Diagnostics & Therapy) provide better penetration of therapeutic and diagnostic substances within the body at a reduced risk in comparison to conventional therapies. At the present time, there is a growing need to enhance the capability of theranostics procedures where nanomaterials-based sensors may provide for the simultaneous detection of several gene-associated conditions and nanodevices with the ability to monitor real-time drug action. These innovative multifunctional nanocarriers for cancer theranostics may allow the development of diagnostics systems such as colorimetric and immunoassays, and in therapy approaches through gene therapy, drug delivery and tumor targeting systems in cancer. Some of the thousands and thousands of published nanosystems so far will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their integration in future diagnostics platforms. Nevertheless, despite the significant efforts towards the use of nanomaterials in biologically relevant research, more in vivo studies are needed to assess the applicability of these materials as delivery agents. In fact, only a few went through feasible clinical trials. Nanomaterials have to serve as the norm rather than an exception in the future conventional cancer treatments. Future in vivo work will need to carefully consider the correct choice of chemical modifications to incorporate into the multifunctional nanocarriers to avoid activation off-target, side effects and toxicity. Moreover the majority of studies on nanomaterials do not consider the final application to guide the design of nanomaterial. Instead, the focus is predominantly on engineering materials with specific physical or chemical properties. It is imperative to learn how advances in nanosystem’s capabilities are being used to identify new diagnostic and therapy tools driving the development of personalized medicine in oncology; discover how integrating cancer research and nanotechnology modeling can help patient diagnosis and treatment; recognize how to translate nanotheranostics data into an actionable clinical strategy; discuss with industry leaders how nanotheranostics is evolving and what the impact is on current research efforts; and last but not least, learn what approaches are proving fruitful in turning promising clinical data into treatment realities. 2021-02-11T09:28:19Z 2021-02-11T09:28:19Z 2016-04-07 11:22:02 2016 book 18894 16648714 9782889197767 https://directory.doabooks.org/handle/20.500.12854/42645 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Cancer_Nanotheranostics_What_Have_We_Learned_so_far_/825 http://journal.frontiersin.org/researchtopic/2709/cancer-nanotheranostics-what-have-we-learned-so-far Frontiers Media SA 10.3389/978-2-88919-776-7 10.3389/978-2-88919-776-7 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889197767 128 open access |
| spellingShingle | QD1-999 Q1-390 Nanoparticles Gene Therapy Immunotherapy bioimaging theranostics nanomaterials Drug delivery Nanomedicine Cancer Phototherapy thema EDItEUR::P Mathematics and Science::PN Chemistry Pedro Viana Baptista Jesus M. De La Fuente Joao Conde Furong Tian Cancer Nanotheranostics: What Have We Learned So Far? |
| title | Cancer Nanotheranostics: What Have We Learned So Far? |
| title_full | Cancer Nanotheranostics: What Have We Learned So Far? |
| title_fullStr | Cancer Nanotheranostics: What Have We Learned So Far? |
| title_full_unstemmed | Cancer Nanotheranostics: What Have We Learned So Far? |
| title_short | Cancer Nanotheranostics: What Have We Learned So Far? |
| title_sort | cancer nanotheranostics what have we learned so far |
| topic | QD1-999 Q1-390 Nanoparticles Gene Therapy Immunotherapy bioimaging theranostics nanomaterials Drug delivery Nanomedicine Cancer Phototherapy thema EDItEUR::P Mathematics and Science::PN Chemistry |
| topic_facet | QD1-999 Q1-390 Nanoparticles Gene Therapy Immunotherapy bioimaging theranostics nanomaterials Drug delivery Nanomedicine Cancer Phototherapy thema EDItEUR::P Mathematics and Science::PN Chemistry |
| url | 18894 |
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