Catalyzed Synthesis of Natural Products
Natural products have been a source of inspiration for chemists and chemical biologists for many years, and have a special relevance in the chemical space. In recent years, several novel synthetic strategies have appeared, such as diversity-oriented synthesis (DOS), biological-oriented synthesis (Bi...
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| _version_ | 1869518775523475456 |
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| author | Díez, David |
| author_browse | Díez, David |
| author_facet | Díez, David |
| author_sort | Díez, David |
| collection | Directory of Open Access Books |
| description | Natural products have been a source of inspiration for chemists and chemical biologists for many years, and have a special relevance in the chemical space. In recent years, several novel synthetic strategies have appeared, such as diversity-oriented synthesis (DOS), biological-oriented synthesis (BiOS), and function-oriented synthesis (FOS), for accessing complex and functionally diverse molecules. In this manner, the synthesis of natural products has evolved towards simpler and ecological methods using biotransformation, combinatorial chemistry, or organocatalysts. In this issue, Prof. Chojnacka shows demonstrates the use of immobilized lipases as catalysts to aid in the synthesis of phosphatidylcholine enriched with myristic acid. Profs. Vila and Pedro used catalysts derived from (S)-mandelic acid to achieve the catalytic enantioselective addition of dimethylzinc to isatins. Prof. Diez shows the possibility of the obtention of 7,8-carvone epoxides in a diastereoselective manner using proline, quinidine, and diphenylprolinol as organocatalysts. A cheap, simple, clean, and scalable method involves the use of deep eutectic mixtures as reaction media, and Profs. Alonso and Guillena describe the use of this methodology for the enantioselective, organocatalyzed ?-amination of 1,3-dicarbonyl compounds. Biotransformations have been one of the methodologies for more efficient synthesis of natural products. Prof. Wu transforms ergostane triterpenoid antcin K using Psychrobacillus sp. Ak 187. Finally, Prof. Kovayashi reviews the total synthesis and biological evaluation of phaeosphaerides. The reader, through this issue, could gain an idea of the new directions that the synthesis of natural products using catalysts will have in the years to come. |
| format | Online |
| id | doab-20.500.12854ir-42797 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-427972024-04-05T12:39:01Z Catalyzed Synthesis of Natural Products Díez, David QD1-999 QD241-441 Q1-390 n/a structured phosphatidylcholine carvone immobilized lipases trimyristin 3-hydroxyoxindole green chemistry structural revision anticancer triterpenoid organocatalysis natural products epoxidation ?-amination benzimidazole total synthesis zinc Antrodia cinnamomea aminocatalysis epoxide asymmetric organocatalysis mandelamides STAT3 asymmetric catalysis Psychrobacillus isatin chiral ?-hydroxyamide interesterification proline phaeosphaeride B biotransformation phaeosphaeride A myristic acid egg-yolk phosphatidylcholine acidolysis antcin K deep eutectic solvents thema EDItEUR::P Mathematics and Science::PN Chemistry Natural products have been a source of inspiration for chemists and chemical biologists for many years, and have a special relevance in the chemical space. In recent years, several novel synthetic strategies have appeared, such as diversity-oriented synthesis (DOS), biological-oriented synthesis (BiOS), and function-oriented synthesis (FOS), for accessing complex and functionally diverse molecules. In this manner, the synthesis of natural products has evolved towards simpler and ecological methods using biotransformation, combinatorial chemistry, or organocatalysts. In this issue, Prof. Chojnacka shows demonstrates the use of immobilized lipases as catalysts to aid in the synthesis of phosphatidylcholine enriched with myristic acid. Profs. Vila and Pedro used catalysts derived from (S)-mandelic acid to achieve the catalytic enantioselective addition of dimethylzinc to isatins. Prof. Diez shows the possibility of the obtention of 7,8-carvone epoxides in a diastereoselective manner using proline, quinidine, and diphenylprolinol as organocatalysts. A cheap, simple, clean, and scalable method involves the use of deep eutectic mixtures as reaction media, and Profs. Alonso and Guillena describe the use of this methodology for the enantioselective, organocatalyzed ?-amination of 1,3-dicarbonyl compounds. Biotransformations have been one of the methodologies for more efficient synthesis of natural products. Prof. Wu transforms ergostane triterpenoid antcin K using Psychrobacillus sp. Ak 187. Finally, Prof. Kovayashi reviews the total synthesis and biological evaluation of phaeosphaerides. The reader, through this issue, could gain an idea of the new directions that the synthesis of natural products using catalysts will have in the years to come. 2021-02-11T09:34:48Z 2021-02-11T09:34:48Z 2020-01-07 09:08:26 2019 book 43230 9783039219483 9783039219490 https://directory.doabooks.org/handle/20.500.12854/42797 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/1898 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03921-949-0 10.3390/books978-3-03921-949-0 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039219483 9783039219490 82 open access |
| spellingShingle | QD1-999 QD241-441 Q1-390 n/a structured phosphatidylcholine carvone immobilized lipases trimyristin 3-hydroxyoxindole green chemistry structural revision anticancer triterpenoid organocatalysis natural products epoxidation ?-amination benzimidazole total synthesis zinc Antrodia cinnamomea aminocatalysis epoxide asymmetric organocatalysis mandelamides STAT3 asymmetric catalysis Psychrobacillus isatin chiral ?-hydroxyamide interesterification proline phaeosphaeride B biotransformation phaeosphaeride A myristic acid egg-yolk phosphatidylcholine acidolysis antcin K deep eutectic solvents thema EDItEUR::P Mathematics and Science::PN Chemistry Díez, David Catalyzed Synthesis of Natural Products |
| title | Catalyzed Synthesis of Natural Products |
| title_full | Catalyzed Synthesis of Natural Products |
| title_fullStr | Catalyzed Synthesis of Natural Products |
| title_full_unstemmed | Catalyzed Synthesis of Natural Products |
| title_short | Catalyzed Synthesis of Natural Products |
| title_sort | catalyzed synthesis of natural products |
| topic | QD1-999 QD241-441 Q1-390 n/a structured phosphatidylcholine carvone immobilized lipases trimyristin 3-hydroxyoxindole green chemistry structural revision anticancer triterpenoid organocatalysis natural products epoxidation ?-amination benzimidazole total synthesis zinc Antrodia cinnamomea aminocatalysis epoxide asymmetric organocatalysis mandelamides STAT3 asymmetric catalysis Psychrobacillus isatin chiral ?-hydroxyamide interesterification proline phaeosphaeride B biotransformation phaeosphaeride A myristic acid egg-yolk phosphatidylcholine acidolysis antcin K deep eutectic solvents thema EDItEUR::P Mathematics and Science::PN Chemistry |
| topic_facet | QD1-999 QD241-441 Q1-390 n/a structured phosphatidylcholine carvone immobilized lipases trimyristin 3-hydroxyoxindole green chemistry structural revision anticancer triterpenoid organocatalysis natural products epoxidation ?-amination benzimidazole total synthesis zinc Antrodia cinnamomea aminocatalysis epoxide asymmetric organocatalysis mandelamides STAT3 asymmetric catalysis Psychrobacillus isatin chiral ?-hydroxyamide interesterification proline phaeosphaeride B biotransformation phaeosphaeride A myristic acid egg-yolk phosphatidylcholine acidolysis antcin K deep eutectic solvents thema EDItEUR::P Mathematics and Science::PN Chemistry |
| url | 43230 |
| work_keys_str_mv | AT diezdavid catalyzedsynthesisofnaturalproducts |