The CB2 Cannabinoid System: A New Strategy in Neurodegenerative Disorder and Neuroinflammation
The neurodegenerative disorders such as Parkinson’s disease (PD) or Alzheimer’s disease (AD) are the most common forms of dementia and no pharmacological treatments are to date available for these diseases. Indeed, the only used drugs are symptomatic and no useful to block the progression of the dis...
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| Aineistotyyppi: | Online |
| Kieli: | englanti |
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Frontiers Media SA
2021
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| Linkit: | 24027 |
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| _version_ | 1869524772815110144 |
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| author | Marialessandra Contino Nicola A. Colabufo Elena Capparelli Ashley I. Bush |
| author_browse | Ashley I. Bush Elena Capparelli Marialessandra Contino Nicola A. Colabufo |
| author_facet | Marialessandra Contino Nicola A. Colabufo Elena Capparelli Ashley I. Bush |
| author_sort | Marialessandra Contino |
| collection | Directory of Open Access Books |
| description | The neurodegenerative disorders such as Parkinson’s disease (PD) or Alzheimer’s disease (AD) are the most common forms of dementia and no pharmacological treatments are to date available for these diseases. Indeed, the only used drugs are symptomatic and no useful to block the progression of the diseases. The lack of a therapeutic approach is also due to a lack of an early diagnosis. This Research Topic describes a new target that is involved in the firs step of these disorders and that can be useful for the treatment and the diagnosis of such pathologies: the cannabinoid receptor subtype 2 or CB2R. Indeed, CB2R is overexpressed in reactive microglia and activated astrocytes during neuroinflammation and thus their detection by PET probes can be an easily strategy for an early diagnosis of neurodegeneration. Moreover, CB2 agonists and inverse agonists displayed neuroprotective effects and they so can be candidated as new therapeutich drugs for the treatment of these pathologies. Therefore, the aim of this Research Topic is to show the great potential of CB2R ligands for the development of new tools/drugs for both the therapy and the diagnosis of neurodegeneration. |
| format | Online |
| id | doab-20.500.12854ir-42833 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-428332024-04-05T17:30:53Z The CB2 Cannabinoid System: A New Strategy in Neurodegenerative Disorder and Neuroinflammation Marialessandra Contino Nicola A. Colabufo Elena Capparelli Ashley I. Bush RC321-571 Q1-390 Cannabinod system CB2 receptor CB2R inverse AD PD neurodegeneration CB2R agonist Inflammation thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences The neurodegenerative disorders such as Parkinson’s disease (PD) or Alzheimer’s disease (AD) are the most common forms of dementia and no pharmacological treatments are to date available for these diseases. Indeed, the only used drugs are symptomatic and no useful to block the progression of the diseases. The lack of a therapeutic approach is also due to a lack of an early diagnosis. This Research Topic describes a new target that is involved in the firs step of these disorders and that can be useful for the treatment and the diagnosis of such pathologies: the cannabinoid receptor subtype 2 or CB2R. Indeed, CB2R is overexpressed in reactive microglia and activated astrocytes during neuroinflammation and thus their detection by PET probes can be an easily strategy for an early diagnosis of neurodegeneration. Moreover, CB2 agonists and inverse agonists displayed neuroprotective effects and they so can be candidated as new therapeutich drugs for the treatment of these pathologies. Therefore, the aim of this Research Topic is to show the great potential of CB2R ligands for the development of new tools/drugs for both the therapy and the diagnosis of neurodegeneration. 2021-02-11T09:35:49Z 2021-02-11T09:35:49Z 2017-10-13 14:57:01 2017 book 24027 16648714 9782889452231 https://directory.doabooks.org/handle/20.500.12854/42833 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/The_CB2_Cannabinoid_System_a_New_Strategy_in_Neurodegenerative_Disorder_and_Neuroinflammation/1285 http://journal.frontiersin.org/researchtopic/3951/the-cb2-cannabinoid-system-a-new-strategy-in-neurodegenerative-disorder-and-neuroinflammation Frontiers Media SA 10.3389/978-2-88945-223-1 10.3389/978-2-88945-223-1 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889452231 100 open access |
| spellingShingle | RC321-571 Q1-390 Cannabinod system CB2 receptor CB2R inverse AD PD neurodegeneration CB2R agonist Inflammation thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Marialessandra Contino Nicola A. Colabufo Elena Capparelli Ashley I. Bush The CB2 Cannabinoid System: A New Strategy in Neurodegenerative Disorder and Neuroinflammation |
| title | The CB2 Cannabinoid System: A New Strategy in Neurodegenerative Disorder and Neuroinflammation |
| title_full | The CB2 Cannabinoid System: A New Strategy in Neurodegenerative Disorder and Neuroinflammation |
| title_fullStr | The CB2 Cannabinoid System: A New Strategy in Neurodegenerative Disorder and Neuroinflammation |
| title_full_unstemmed | The CB2 Cannabinoid System: A New Strategy in Neurodegenerative Disorder and Neuroinflammation |
| title_short | The CB2 Cannabinoid System: A New Strategy in Neurodegenerative Disorder and Neuroinflammation |
| title_sort | cb2 cannabinoid system a new strategy in neurodegenerative disorder and neuroinflammation |
| topic | RC321-571 Q1-390 Cannabinod system CB2 receptor CB2R inverse AD PD neurodegeneration CB2R agonist Inflammation thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Cannabinod system CB2 receptor CB2R inverse AD PD neurodegeneration CB2R agonist Inflammation thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 24027 |
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