Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function
Brain derived neurotophic factor (BDNF) and its receptor tropomyosin receptor kinase B (TrkB) signaling has been extensively studied for its roles in the central nervous system (CNS) ranging from cell survival, axonal and dendritic growth and synapse formation. Intracellular signaling pathways trigg...
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| Định dạng: | Online |
| Ngôn ngữ: | Tiếng Anh |
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Frontiers Media SA
2021
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| Những chủ đề: | |
| Truy cập trực tuyến: | 19546 |
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| _version_ | 1869518040855478272 |
|---|---|
| author | Nancy Y. Ip Akira Yoshii Martha Constantine-Paton |
| author_browse | Akira Yoshii Martha Constantine-Paton Nancy Y. Ip |
| author_facet | Nancy Y. Ip Akira Yoshii Martha Constantine-Paton |
| author_sort | Nancy Y. Ip |
| collection | Directory of Open Access Books |
| description | Brain derived neurotophic factor (BDNF) and its receptor tropomyosin receptor kinase B (TrkB) signaling has been extensively studied for its roles in the central nervous system (CNS) ranging from cell survival, axonal and dendritic growth and synapse formation. Intracellular signaling pathways triggered by BDNF activate gene transcription, translation, post-translational functions, trafficking of key synaptic proteins, and synaptic release mechanism. BDNF-TrkB signaling mediates long-lasting activity-modulated synaptic changes on excitatory and inhibitory neurons and plays significant roles in circuit development and modulation. Furthermore, this pathway is critical for learning, memory, sensory processing and other cognitive functions, and is implicated in neurological and psychiatric diseases. In addition to BDNF, more recent studies have identified new “growth” factors that play important roles in the development, maturation and maintenance and modulation of synaptic function. However, details of the cytoplamic signaling systems downstream of these synaptogenic factors are often less understood than conventional neurotophin signaling. This e-Book has collected original studies and review articles that present cellular and molecular mechanisms concerning activity-dependent synapse formation and their implications for behavior and brain disorders. It is our hope that readers will perceive this volume as a showcase for diversity and complexity of synaptogenic growth factors, and will stimulate further studies in this field. |
| format | Online |
| id | doab-20.500.12854ir-42852 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-428522024-04-05T12:35:50Z Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function Nancy Y. Ip Akira Yoshii Martha Constantine-Paton RC321-571 Q1-390 netrin neuropsychiatric disease adult neurogenesis FGF7 lipid raft BDNF Leptin Rho GTPase synapse formation FGF22 thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Brain derived neurotophic factor (BDNF) and its receptor tropomyosin receptor kinase B (TrkB) signaling has been extensively studied for its roles in the central nervous system (CNS) ranging from cell survival, axonal and dendritic growth and synapse formation. Intracellular signaling pathways triggered by BDNF activate gene transcription, translation, post-translational functions, trafficking of key synaptic proteins, and synaptic release mechanism. BDNF-TrkB signaling mediates long-lasting activity-modulated synaptic changes on excitatory and inhibitory neurons and plays significant roles in circuit development and modulation. Furthermore, this pathway is critical for learning, memory, sensory processing and other cognitive functions, and is implicated in neurological and psychiatric diseases. In addition to BDNF, more recent studies have identified new “growth” factors that play important roles in the development, maturation and maintenance and modulation of synaptic function. However, details of the cytoplamic signaling systems downstream of these synaptogenic factors are often less understood than conventional neurotophin signaling. This e-Book has collected original studies and review articles that present cellular and molecular mechanisms concerning activity-dependent synapse formation and their implications for behavior and brain disorders. It is our hope that readers will perceive this volume as a showcase for diversity and complexity of synaptogenic growth factors, and will stimulate further studies in this field. 2021-02-11T09:36:26Z 2021-02-11T09:36:26Z 2016-08-16 10:34:25 2015 book 19546 16648714 9782889196432 https://directory.doabooks.org/handle/20.500.12854/42852 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Cell_and_molecular_signaling_and_transport_pathways_involved_in_growth_factor_control_of_synaptic_d/677#nogo http://journal.frontiersin.org/researchtopic/1156/cell-and-molecular-signaling-and-transport-pathways-involved-in-growth-factor-control-of-synaptic-de Frontiers Media SA 10.3389/978-2-88919-643-2 10.3389/978-2-88919-643-2 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889196432 112 open access |
| spellingShingle | RC321-571 Q1-390 netrin neuropsychiatric disease adult neurogenesis FGF7 lipid raft BDNF Leptin Rho GTPase synapse formation FGF22 thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Nancy Y. Ip Akira Yoshii Martha Constantine-Paton Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function |
| title | Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function |
| title_full | Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function |
| title_fullStr | Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function |
| title_full_unstemmed | Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function |
| title_short | Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function |
| title_sort | cell and molecular signaling and transport pathways involved in growth factor control of synaptic development and function |
| topic | RC321-571 Q1-390 netrin neuropsychiatric disease adult neurogenesis FGF7 lipid raft BDNF Leptin Rho GTPase synapse formation FGF22 thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 netrin neuropsychiatric disease adult neurogenesis FGF7 lipid raft BDNF Leptin Rho GTPase synapse formation FGF22 thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 19546 |
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