Cellular and Phenotypic Plasticity in Cancer
The process of Epithelial-Mesenchymal-Transition (EMT) is known to result in a phenotype change in cells from a proliferative state to a more invasive state. EMT has been reported to drive the metastatic spread of various cancers and has also been associated with drug resistance to cytotoxics and ta...
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| Formaat: | Online |
| Taal: | Engels |
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Frontiers Media SA
2021
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| _version_ | 1869531029460484096 |
|---|---|
| author | Petranel Theresa Ferrao Andreas Behren Erik Thompson Robin Anderson |
| author_browse | Andreas Behren Erik Thompson Petranel Theresa Ferrao Robin Anderson |
| author_facet | Petranel Theresa Ferrao Andreas Behren Erik Thompson Robin Anderson |
| author_sort | Petranel Theresa Ferrao |
| collection | Directory of Open Access Books |
| description | The process of Epithelial-Mesenchymal-Transition (EMT) is known to result in a phenotype change in cells from a proliferative state to a more invasive state. EMT has been reported to drive the metastatic spread of various cancers and has also been associated with drug resistance to cytotoxics and targeted therapeutics. Recently phenotype switching akin to EMT has been reported in non-epithelial cancers such as metastatic melanoma. This process involves changes in EMT-Transcription Factors (EMT-TFs), suggesting that phenotype-switching may be common to several tumour types. It remains unclear as to whether the presence of both Epilthelial-like and Mesenchymal-like cells are a pre-requisite for phenotype switching within a tumour, how this heterogeneity is regulated, and if alteration of cell phenotype is sufficient to mediate migratory changes, or whether drivers of cell migration result in an associated phenotype switch in cancer cells. Similarly it has yet to be clarified if cells in an altered phenotype can be refractory to drug therapy or whether mediators of drug resistance induce a concurrent phenotypic change. Little is known today about the underlying genetic, epigenetic and transient changes that accompany this phenotypic switch and about the role for the tumor micro-environment in influencing it. Hence this is currently an area of speculation and keen interest in the Oncology field with wide-ranging translational implications. In this Frontiers Research Topic, we discuss our current understanding of these concepts in various cancer types including breast cancer, colorectal cancer and metastatic melanoma. This topic covers how these processes of cellular and phenotypic plasticity are regulated and how they relate to cancer initiation, progression, dormancy, metastases and response to cytotoxics or targeted therapies. |
| format | Online |
| id | doab-20.500.12854ir-42865 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-428652024-03-31T13:10:17Z Cellular and Phenotypic Plasticity in Cancer Petranel Theresa Ferrao Andreas Behren Erik Thompson Robin Anderson R5-920 RC254-282 crosstalk Immune System Phenotype-switching plasticity Exosomes EMT Therapy-resistance signalling heterogeneity Cancer thema EDItEUR::M Medicine and Nursing The process of Epithelial-Mesenchymal-Transition (EMT) is known to result in a phenotype change in cells from a proliferative state to a more invasive state. EMT has been reported to drive the metastatic spread of various cancers and has also been associated with drug resistance to cytotoxics and targeted therapeutics. Recently phenotype switching akin to EMT has been reported in non-epithelial cancers such as metastatic melanoma. This process involves changes in EMT-Transcription Factors (EMT-TFs), suggesting that phenotype-switching may be common to several tumour types. It remains unclear as to whether the presence of both Epilthelial-like and Mesenchymal-like cells are a pre-requisite for phenotype switching within a tumour, how this heterogeneity is regulated, and if alteration of cell phenotype is sufficient to mediate migratory changes, or whether drivers of cell migration result in an associated phenotype switch in cancer cells. Similarly it has yet to be clarified if cells in an altered phenotype can be refractory to drug therapy or whether mediators of drug resistance induce a concurrent phenotypic change. Little is known today about the underlying genetic, epigenetic and transient changes that accompany this phenotypic switch and about the role for the tumor micro-environment in influencing it. Hence this is currently an area of speculation and keen interest in the Oncology field with wide-ranging translational implications. In this Frontiers Research Topic, we discuss our current understanding of these concepts in various cancer types including breast cancer, colorectal cancer and metastatic melanoma. This topic covers how these processes of cellular and phenotypic plasticity are regulated and how they relate to cancer initiation, progression, dormancy, metastases and response to cytotoxics or targeted therapies. 2021-02-11T09:36:53Z 2021-02-11T09:36:53Z 2016-08-16 10:34:25 2015 book 19563 16648714 9782889196623 https://directory.doabooks.org/handle/20.500.12854/42865 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Cellular_and_Phenotypic_Plasticity_in_Cancer/687#nogo http://journal.frontiersin.org/researchtopic/2968/cellular-and-phenotypic-plasticity-in-cancer Frontiers Media SA 10.3389/978-2-88919-662-3 10.3389/978-2-88919-662-3 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889196623 77 open access |
| spellingShingle | R5-920 RC254-282 crosstalk Immune System Phenotype-switching plasticity Exosomes EMT Therapy-resistance signalling heterogeneity Cancer thema EDItEUR::M Medicine and Nursing Petranel Theresa Ferrao Andreas Behren Erik Thompson Robin Anderson Cellular and Phenotypic Plasticity in Cancer |
| title | Cellular and Phenotypic Plasticity in Cancer |
| title_full | Cellular and Phenotypic Plasticity in Cancer |
| title_fullStr | Cellular and Phenotypic Plasticity in Cancer |
| title_full_unstemmed | Cellular and Phenotypic Plasticity in Cancer |
| title_short | Cellular and Phenotypic Plasticity in Cancer |
| title_sort | cellular and phenotypic plasticity in cancer |
| topic | R5-920 RC254-282 crosstalk Immune System Phenotype-switching plasticity Exosomes EMT Therapy-resistance signalling heterogeneity Cancer thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC254-282 crosstalk Immune System Phenotype-switching plasticity Exosomes EMT Therapy-resistance signalling heterogeneity Cancer thema EDItEUR::M Medicine and Nursing |
| url | 19563 |
| work_keys_str_mv | AT petraneltheresaferrao cellularandphenotypicplasticityincancer AT andreasbehren cellularandphenotypicplasticityincancer AT erikthompson cellularandphenotypicplasticityincancer AT robinanderson cellularandphenotypicplasticityincancer |